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\u30101\u3011Petersen B, Wulf HC. Application of sunscreen\u2014theory and reality. Photodermatol Photoimmunol Photomed. 2014;30(2\u20133):96\u2013101.<\/a><\/cite>\r\n\r\nPMID: 24313722\u3000DOI: 10.1111\/phpp.12100\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u65e5\u713c\u3051\u6b62\u3081\u306e\u8868\u793aSPF\u5024\u306f\u7406\u60f3\u7684\u306a\u5857\u5e03\u91cf\uff082 mg\/cm\u00b2\uff09\u3092\u524d\u63d0\u3068\u3057\u3066\u8a55\u4fa1\u3055\u308c\u308b\u304c\u3001\u5b9f\u969b\u306e\u4f7f\u7528\u3067\u306f\u591a\u304f\u306e\u4eba\u304c\u3053\u306e\u91cf\u3092\u5927\u5e45\u306b\u4e0b\u56de\u3063\u3066\u5857\u5e03\u3057\u3066\u304a\u308a\u3001\u7d50\u679c\u3068\u3057\u3066\u8868\u793a\u5024\u306e20-50%\u7a0b\u5ea6\u306e\u9632\u5fa1\u52b9\u679c\u3057\u304b\u5f97\u3089\u308c\u3066\u3044\u306a\u3044\u3002\u82b1\u7c89\u306b\u3088\u308b\u808c\u8352\u308c\u6642\u306f\u7d2b\u5916\u7dda\u306b\u3088\u308b\u8ffd\u52a0\u30c0\u30e1\u30fc\u30b8\u304c\u76ae\u819a\u30d0\u30ea\u30a2\u3092\u3055\u3089\u306b\u60aa\u5316\u3055\u305b\u308b\u305f\u3081\u3001\u9069\u5207\u306a\u91cf\u3068\u65b9\u6cd5\u3067\u306e\u65e5\u713c\u3051\u6b62\u3081\u4f7f\u7528\u304c\u6975\u3081\u3066\u91cd\u8981\u3067\u3042\u308b\u3002\u672c\u8ad6\u6587\u306f\u5857\u5e03\u91cf\u3001\u5857\u308a\u76f4\u3057\u983b\u5ea6\u3001\u30ab\u30d0\u30fc\u90e8\u4f4d\u306e\u91cd\u8981\u6027\u3092\u79d1\u5b66\u7684\u306b\u691c\u8a3c\u3057\u3001\u654f\u611f\u808c\u3067\u3082\u4f7f\u3048\u308b\u65e5\u713c\u3051\u6b62\u3081\u306e\u9069\u5207\u306a\u4f7f\u7528\u6cd5\u306e\u6839\u62e0\u3068\u306a\u308b\u7814\u7a76\u3067\u3042\u308b\u3002\r\n\r\n\u30102\u3011Furue M, Chiba T, Tsuji G, et al. Atopic dermatitis: immune deviation, barrier dysfunction, IgE autoreactivity and new therapies. Allergol Int. 2017;66(3):398-403.<\/a><\/cite>\r\n\r\nPMID: 28057434\u3000DOI: 10.1016\/j.alit.2016.12.002\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u306b\u304a\u3051\u308b\u76ae\u819a\u30d0\u30ea\u30a2\u6a5f\u80fd\u969c\u5bb3\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u5305\u62ec\u7684\u306b\u89e3\u8aac\u3057\u305f\u65e5\u672c\u306e\u7814\u7a76\u3002Th2\/Th22\u578b\u514d\u75ab\u53cd\u5fdc\u304c\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u767a\u73fe\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u76ae\u819a\u30d0\u30ea\u30a2\u3092\u3055\u3089\u306b\u60aa\u5316\u3055\u305b\u308b\u60aa\u5faa\u74b0\u3092\u793a\u3057\u3066\u3044\u308b\u3002\u82b1\u7c89\u306a\u3069\u306e\u5916\u7684\u523a\u6fc0\u306b\u5bfe\u3057\u3066\u76ae\u819a\u304c\u8106\u5f31\u306b\u306a\u308b\u7406\u7531\u3092\u514d\u75ab\u5b66\u7684\u30fb\u751f\u5316\u5b66\u7684\u306b\u8aac\u660e\u3057\u3001TSLP(\u80f8\u817a\u9593\u8cea\u6027\u30ea\u30f3\u30d1\u7403\u65b0\u751f\u56e0\u5b50)\u304cTh2\u514d\u75ab\u5fdc\u7b54\u3092\u958b\u59cb\u3055\u305b\u308b\u3053\u3068\u3067\u75d2\u307f\u3068\u708e\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u6a5f\u5e8f\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002\u4fdd\u6e7f\u30b1\u30a2\u306b\u3088\u308b\u30d0\u30ea\u30a2\u6a5f\u80fd\u56de\u5fa9\u306e\u91cd\u8981\u6027\u3092\u79d1\u5b66\u7684\u306b\u88cf\u4ed8\u3051\u308b\u6839\u62e0\u8ad6\u6587\u3067\u3042\u308a\u3001\u82b1\u7c89\u306b\u3088\u308b\u808c\u8352\u308c\u306e\u75c5\u614b\u7406\u89e3\u3068\u5bfe\u7b56\u306e\u57fa\u790e\u3068\u306a\u308b\u3002\r\n\r\n\u30103\u3011Simpson EL, Chalmers JR, Hanifin JM, et al. Improvement of skin barrier function in atopic dermatitis patients with a new moisturizer containing a ceramide precursor. J Dermatolog Treat. 2013;24(2):122-5.<\/a><\/cite>\r\n\r\nPMID: 22812593\u3000DOI: 10.3109\/09546634.2012.713461\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u60a3\u8005\u306b\u304a\u3044\u3066\u30bb\u30e9\u30df\u30c9\u524d\u99c6\u4f53\u542b\u6709\u4fdd\u6e7f\u5264\u304c\u76ae\u819a\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u6709\u610f\u306b\u6539\u5584\u3059\u308b\u3053\u3068\u3092\u5b9f\u8a3c\u3057\u305f\u7121\u4f5c\u70ba\u5316\u6bd4\u8f03\u8a66\u9a13\u30024\u9031\u9593\u306e\u4f7f\u7528\u3067\u7d4c\u76ae\u6c34\u5206\u84b8\u6563\u91cf(TEWL)\u306e\u6709\u610f\u306a\u6e1b\u5c11\u3001\u89d2\u5c64\u6c34\u5206\u91cf\u306e\u5897\u52a0\u3001\u81e8\u5e8a\u7684\u4e7e\u71e5\u30b9\u30b3\u30a2\u306e\u6539\u5584\u304c\u8a8d\u3081\u3089\u308c\u305f(\u3059\u3079\u3066p<0.01)\u3002\u30e9\u30de\u30f3\u5206\u5149\u6cd5\u306b\u3088\u308b\u89e3\u6790\u3067\u89d2\u5c64\u8102\u8cea\u542b\u6709\u91cf\u306e\u5897\u52a0\u3082\u78ba\u8a8d\u3055\u308c\u3001\u30bb\u30e9\u30df\u30c9\u304c\u76ae\u819a\u306e\u69cb\u9020\u7684\u30fb\u6a5f\u80fd\u7684\u30d0\u30ea\u30a2\u3092\u5b9f\u969b\u306b\u5f37\u5316\u3059\u308b\u3053\u3068\u3092\u79d1\u5b66\u7684\u306b\u8a3c\u660e\u3057\u305f\u3002\u82b1\u7c89\u523a\u6fc0\u3067\u640d\u306a\u308f\u308c\u305f\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u4fee\u5fa9\u3059\u308b\u4fdd\u6e7f\u30b1\u30a2\u306e\u6709\u52b9\u6027\u3092\u793a\u3059\u91cd\u8981\u306a\u30a8\u30d3\u30c7\u30f3\u30b9\u3067\u3042\u308b\u3002\r\n\r\n\u30104\u3011Ananthapadmanabhan KP, Moore DJ, Subramanyan K, et al. Cleansing without compromise: the impact of cleansers on the skin barrier and the technology of mild cleansing. Dermatol Ther. 2004;17(Suppl 1):16-25.<\/a><\/cite>\r\n\r\nPMID: 14728695\u3000DOI: 10.1111\/j.1396-0296.2004.04S1002.x\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u6d17\u6d44\u5264\u304c\u76ae\u819a\u30d0\u30ea\u30a2\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3092\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u89e3\u6790\u3057\u3001\u30de\u30a4\u30eb\u30c9\u306a\u6d17\u6d44\u6280\u8853\u3092\u79d1\u5b66\u7684\u306b\u691c\u8a3c\u3057\u305f\u30ec\u30d3\u30e5\u30fc\u8ad6\u6587\u3002\u754c\u9762\u6d3b\u6027\u5264\u306f\u76ae\u819a\u30bf\u30f3\u30d1\u30af\u8cea\u30fb\u8102\u8cea\u3068\u76f8\u4e92\u4f5c\u7528\u3057\u3066\u89d2\u5c64\u81a8\u6f64\u3001\u8102\u8cea\u525b\u6027\u5909\u5316\u3001\u30d0\u30ea\u30a2\u640d\u50b7\u3092\u5f15\u304d\u8d77\u3053\u3059\u304c\u3001\u305d\u306e\u7a0b\u5ea6\u306f\u754c\u9762\u6d3b\u6027\u5264\u306e\u7a2e\u985e\u3068\u6d17\u6d44\u5264\u306epH\u306b\u5927\u304d\u304f\u4f9d\u5b58\u3059\u308b\u3002\u9ad8pH(pH10)\u6eb6\u6db2\u306f\u754c\u9762\u6d3b\u6027\u5264\u306a\u3057\u3067\u3082\u89d2\u5c64\u3092\u640d\u50b7\u3059\u308b\u305f\u3081\u3001pH5.5\u524d\u5f8c\u306e\u5f31\u9178\u6027\u6d17\u6d44\u5264\u304c\u76ae\u819a\u3078\u306e\u8ca0\u62c5\u304c\u5c11\u306a\u3044\u3002\u82b1\u7c89\u4ed8\u7740\u3092\u6d17\u3044\u6d41\u3059\u969b\u3001\u9069\u5207\u306a\u6d17\u6d44\u5264\u9078\u629e\u304c\u30d0\u30ea\u30a2\u6a5f\u80fd\u7dad\u6301\u306b\u4e0d\u53ef\u6b20\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3059\u57fa\u790e\u7814\u7a76\u3068\u3057\u3066\u91cd\u8981\u3067\u3042\u308b\u3002\r\n\r\n\u30105\u3011Addor FAS. Antioxidants in dermatology. An Bras Dermatol. 2017 May-Jun;92(3):356-362.<\/a><\/cite>\r\n\r\nPMID: 29186248 PMCID: PMC5514576 DOI: 10.1590\/abd1806-4841.20175697\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff08\u8a73\u7d30\u7248\uff09\uff1a<\/strong>\u76ae\u819a\u7d30\u80de\u306f\u7d30\u80de\u547c\u5438\u3084\u4ee3\u8b1d\u30d7\u30ed\u30bb\u30b9\u3001\u5916\u7684\u523a\u6fc0\u306b\u3088\u308a\u6301\u7d9a\u7684\u306b\u30d5\u30ea\u30fc\u30e9\u30b8\u30ab\u30eb(\u6d3b\u6027\u9178\u7d20\u7a2e)\u3092\u7523\u751f\u3057\u3066\u3044\u308b\u3002\u3053\u308c\u3089\u306f\u901a\u5e38\u3001\u9175\u7d20\u7cfb\u30fb\u975e\u9175\u7d20\u7cfb\u306e\u6297\u9178\u5316\u30b7\u30b9\u30c6\u30e0\u306b\u3088\u308a\u751f\u7406\u7684\u306a\u30d0\u30e9\u30f3\u30b9\u3067\u4e2d\u548c\u3055\u308c\u308b\u304c\u3001\u3053\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u5d29\u308c\u308b\u3068\u7d30\u80de\u819c\u3001\u6838DNA\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\u306a\u3069\u304c\u69cb\u9020\u7684\u640d\u50b7\u3092\u53d7\u3051\u3001\u76ae\u819a\u75be\u60a3\u306e\u767a\u75c7\u3084\u60aa\u5316\u306b\u3064\u306a\u304c\u308b\u3002\u672c\u8ad6\u6587\u306f\u3001\u30d3\u30bf\u30df\u30f3C\u30fbE\u30fb\u30ab\u30ed\u30c6\u30ce\u30a4\u30c9\u30fb\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u30fb\u30b3\u30a8\u30f3\u30b6\u30a4\u30e0Q10\u306a\u3069\u3001\u5c40\u6240\u304a\u3088\u3073\u7d4c\u53e3\u6295\u4e0e\u3055\u308c\u308b\u6297\u9178\u5316\u7269\u8cea\u306e\u4f5c\u7528\u6a5f\u5e8f\u3001\u5b89\u5168\u6027\u3001\u76f8\u4e92\u4f5c\u7528\u3092\u5305\u62ec\u7684\u306b\u30ec\u30d3\u30e5\u30fc\u3057\u305f\u91cd\u8981\u6587\u732e\u3067\u3042\u308b\u3002\r\n\r\n\u7279\u306b\u30d3\u30bf\u30df\u30f3C\u306f\u76ae\u819a\u3067\u6700\u3082\u8c4a\u5bcc\u306a\u6c34\u6eb6\u6027\u6297\u9178\u5316\u7269\u8cea\u3067\u3042\u308a\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u5408\u6210\u4fc3\u9032\u3001\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u6291\u5236\u3001\u30d3\u30bf\u30df\u30f3E\u306e\u518d\u751f\u4f5c\u7528\u3092\u6709\u3059\u308b\u3002\u30d3\u30bf\u30df\u30f3E\u306f\u8102\u8cea\u904e\u9178\u5316\u3092\u9632\u304e\u3001\u7d30\u80de\u819c\u3092\u4fdd\u8b77\u3059\u308b\u8102\u6eb6\u6027\u6297\u9178\u5316\u7269\u8cea\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u3002\u82b1\u7c89\u306b\u3088\u308b\u708e\u75c7\u53cd\u5fdc\u3067\u306f\u904e\u5270\u306a\u6d3b\u6027\u9178\u7d20\u7a2e\u304c\u7523\u751f\u3055\u308c\u308b\u305f\u3081\u3001\u3053\u308c\u3089\u306e\u6297\u9178\u5316\u7269\u8cea\u3092\u7d4c\u53e3\u6442\u53d6\u3084\u5916\u7528\u306b\u3088\u308a\u88dc\u5145\u3059\u308b\u3053\u3068\u3067\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u8efd\u6e1b\u3057\u3001\u708e\u75c7\u3092\u6291\u5236\u3057\u3001\u76ae\u819a\u30d0\u30ea\u30a2\u6a5f\u80fd\u306e\u7dad\u6301\u306b\u5bc4\u4e0e\u3067\u304d\u308b\u3002\u76ae\u819a\u79d1\u9818\u57df\u306b\u304a\u3051\u308b\u6297\u9178\u5316\u7269\u8cea\u306e\u81e8\u5e8a\u5fdc\u7528\u306b\u304a\u3044\u3066\u3001\u305d\u306e\u4f5c\u7528\u6a5f\u5e8f\u3001\u4f7f\u7528\u4e0a\u306e\u5236\u9650\u3001\u6f5c\u5728\u7684\u30ea\u30b9\u30af\u3001\u304a\u3088\u3073\u6709\u52b9\u306a\u7d44\u307f\u5408\u308f\u305b\u306b\u3064\u3044\u3066\u79d1\u5b66\u7684\u6839\u62e0\u3092\u63d0\u4f9b\u3059\u308b\u57fa\u76e4\u8ad6\u6587\u3067\u3042\u308b\u3002\r\n\r\n<\/pre>\n