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class=\"mg1\">\u3060\u304b\u3089\u3001\u4e7e\u71e5\u808c\u306e\u539f\u56e0\u306b\u306a\u3063\u3066\u3057\u307e\u3044\u307e\u3059\u3002<\/p>\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u306f\u5065\u3084\u304b\u306a\u7f8e\u808c\u306e\u305f\u3081\u306b\u3068\u3066\u3082\u5927\u5207\u306a\u6210\u5206\u306e1\u3064\u3067\u3059\u3002<\/p>\n<p class=\"mg1\">\u6b63\u3057\u3044\u30b9\u30ad\u30f3\u30b1\u30a2\u3084\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u306e\u305f\u3081\u306b\u306f\u3001\u76ae\u819a\u306e\u4ed5\u7d44\u307f\u3084\u808c\u306b\u3042\u308b\u6210\u5206\u306e\u306f\u305f\u3089\u304d\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002<\/p>\n<p><strong>\u00a0\u3053\u306e\u8a18\u4e8b\u3067\u306f\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u3068\u306f\u4f55\u304b\uff1f\u305d\u306e\u5f79\u5272\u3092\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/strong><\/p>\n<p class=\"mg1\"><strong>\u307e\u305f\u3001\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u3092\u5897\u3084\u3059\u5316\u7ca7\u54c1\u6210\u5206\u3092\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/strong><\/p>\n<p><em><span class=\"str\">\u300c\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u3063\u3066\u3001\u4e00\u4f53\u3001\u4f55\uff1f\u308f\u304b\u308a\u3084\u3059\u304f\u6559\u3048\u3066\uff01\u300d<\/span><\/em><\/p>\n<p><em><span class=\"str\">\u300c\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u3068\u808c\u60a9\u307f\u306e\u95a2\u4fc2\u306f\uff1f\u306a\u305c\u3001\u5c11\u306a\u3044\u3068\u554f\u984c\u306a\u306e\uff1f\u300d<\/span><\/em><\/p>\n<p><em><span class=\"str\">\u300c\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u3092\u6e1b\u3089\u3055\u306a\u3044\u65b9\u6cd5\u306f\u3042\u308b\u306e\uff1f\u77e5\u308a\u305f\u3044\uff01\u300d<\/span><\/em><\/p>\n<p><em><span class=\"str\">\u300c\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u3060\u3068\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u304c\u5c11\u306a\u3044\uff1f\u6cbb\u7642\u306f\u3069\u3046\u3059\u308b\u306e\uff1f\u300d<\/span><\/em><\/p>\n<p class=\"mg1\"><em><span class=\"str\">\u300c\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u3092\u5897\u3084\u3059\u5316\u7ca7\u54c1\u6210\u5206\u3063\u3066\uff1f\u305c\u3072\u3001\u77e5\u308a\u305f\u3044\uff01\u300d<\/span><\/em><\/p>\n<p class=\"mg1\">\u306a\u3069\u3001\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u306b\u8208\u5473\u304c\u3042\u308b\u65b9\u306f\u3001\u305c\u3072\u3001\u7d9a\u304d\u3092\u30c1\u30a7\u30c3\u30af\u3057\u3066\u307f\u3066\u304f\u3060\u3055\u3044\u306d\u3002<\/p>\n<h2 class=\"md2\">\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u3068\u305d\u306e\u306f\u305f\u3089\u304d<\/h2>\n<h3 class=\"md3\">1\uff09\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u3068\u306f\uff1f<\/h3>\n<p class=\"mg1\">\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u3068\u306f\u3001\u89d2\u8cea\u5c64\u306b\u3042\u308b\u305f\u3093\u3071\u304f\u8cea\u3067\u3059\u3002<\/p>\n<p>\u307e\u305a\u3001\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u306e\u904e\u7a0b\u3067\u3001\u8868\u76ae\u306e\u9846\u7c92\u5c64\u306e\u9846\u7c92\u7d30\u80de\u306e\u306a\u304b\u306b\u5b58\u5728\u3059\u308b\u30ac\u30e9\u30b9\u8cea\u72b6\u306e\u9846\u7c92\u3067\u3042\u308b\u30b1\u30e9\u30c8\u30d2\u30a2\u30ea\u30f3\u9846\u7c92\u306e\u4e2d\u306b\u30d7\u30ed\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u304c\u751f\u307e\u308c\u307e\u3059\u3002<\/p>\n<p class=\"mg1\">\u30d7\u30ed\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u306f\u3001\u9846\u7c92\u5c64\u304b\u3089\u89d2\u8cea\u5c64\u3078\u79fb\u52d5\u3059\u308b\u3068\u9175\u7d20\u306b\u3088\u3063\u3066\u5206\u89e3\u3055\u308c\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<p class=\"mg1\">\uff1c\u30d7\u30ed\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u306e\u5909\u5316\uff1e<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"mg1 alignnone wp-image-49312\" src=\"https:\/\/www.nahls.co.jp\/eijingukea\/wp-content\/uploads\/2021\/07\/7ad26f97649c977a724864b888173745.png\" alt=\"\u30d7\u30ed\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u306e\u5909\u5316\u3092\u8868\u3057\u305f\u56f3\" width=\"600\" height=\"338\" \/><\/p>\n<h3 class=\"md3\">2\uff09\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u306e\u306f\u305f\u3089\u304d<\/h3>\n<p class=\"mg1\">\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u306f\u3001\u8868\u76ae\u306e\u89d2\u8cea\u5c64\u306e\u9aa8\u683c\u3068\u306a\u308b\u305f\u3093\u3071\u304f\u8cea\u300c\u30b1\u30e9\u30c1\u30f3\u7e4a\u7dad\u300d\u3092\u51dd\u96c6\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u5065\u3084\u304b\u3067\u4e08\u592b\u306a<a class=\"link\" href=\"https:\/\/www.nahls.co.jp\/eijingukea\/mechanism\/hyouhi\/hoshitsu\/\" target=\"_blank\" rel=\"noopener\">\u4fdd\u6e7f\u529b<\/a>\u306e\u3042\u308b\u89d2\u8cea\u5c64\u3092\u3064\u304f\u308b\u306f\u305f\u3089\u304d\u306e\u4e2d\u5fc3\u7684\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u307e\u305f\u3001\u305d\u306e\u904e\u7a0b\u3067\u300c\u30d6\u30ec\u30aa\u30de\u30a4\u30b7\u30f3\u6c34\u89e3\u9175\u7d20\uff08BH\uff09\u300d\u306a\u3069\u306e\u9175\u7d20\u306e\u529b\u3092\u501f\u308a\u3066\u30a2\u30df\u30ce\u9178\u306b\u5206\u89e3\u3055\u308c\u307e\u3059\u3002<\/p>\n<p class=\"mg1\">\u305d\u3057\u3066\u3001\u305d\u308c\u304c\u5929\u7136\u4fdd\u6e7f\u56e0\u5b50\uff08NMF\uff09\u306e\u4e3b\u6210\u5206\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<div class=\"mg1\" style=\"background: #f5f5f5; padding: 5px; border: none; border-radius: 10px; -moz-border-radius: 10px; -webkit-border-radius: 10px;\">\n<p><b>\uff1c\u53c2\u7167\u5143\uff1e<\/b><br \/>\n\uff0a<a class=\"link\" href=\"https:\/\/corp.shiseido.com\/jp\/newsimg\/archive\/00000000001259\/1259_n9q22_jp.pdf\" target=\"_blank\" rel=\"noopener\">\u8cc7\u751f\u5802\u3001\u808c\u306e\u5929\u7136\u4fdd\u6e7f\u56e0\u5b50\u300cNMF\u300d\u7523\u751f\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u660e<\/a><\/p>\n<\/div>\n<p>\u5929\u7136\u4fdd\u6e7f\u56e0\u5b50\uff08NMF\uff09\u306f\u3001\u6c34\u5206\u3092\u5438\u7740\u3059\u308b\u4fdd\u6e7f\u6210\u5206\u3067\u3001\u89d2\u8cea\u3084\u89d2\u5c64\u7d30\u80de\u306e\u4e2d\u306b10\uff5e30%\u3042\u308a\u307e\u3059\u3002<\/p>\n<p class=\"mg1\">\u30a2\u30df\u30ce\u9178\u3084PCA-Na\u3068\u3044\u3063\u305f\u30a2\u30df\u30ce\u9178\u4ee3\u8b1d\u7269\u304c\u7d04\u534a\u5206\u3092\u5360\u3081\u3001\u307b\u304b\u306b\u4e73\u9178\u5869\u3001\u5c3f\u7d20\u3001\u30af\u30a8\u30f3\u9178\u5869\u306a\u3069\u3067\u3067\u304d\u3066\u3044\u307e\u3059\u3002<\/p>\n<p class=\"mg1\">\u3053\u306e\u3088\u3046\u306b\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u306f\u3001\u30b1\u30e9\u30c1\u30f3\u7e4a\u7dad\u3092\u51dd\u96c6\u3059\u308b\u3053\u3068\u3068\u3001\u5206\u89e3\u3055\u308c\u3066\u5929\u7136\u4fdd\u6e7f\u56e0\u5b50\uff08NMF\uff09\u306e\u4e3b\u6210\u5206\u3068\u306a\u308b\u3053\u3068\u3067\u3001\u808c\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u304c\u6b63\u5e38\u306b\u306f\u305f\u3089\u304f\u3053\u3068\u3092\u52a9\u3051\u307e\u3059\u3002<\/p>\n<p>\uff1c\u53c2\u8003\u8a18\u4e8b\uff1e<\/p>\n<p>\uff0a<a class=\"link\" href=\"https:\/\/www.nahls.co.jp\/eijingukea\/editorial_news\/kakusou-hoshitsunou\/\" target=\"_blank\" rel=\"noopener\">\u808c\u306e\u4fdd\u6e7f\u80fd\u306b\u5927\u5207\u306a\u89d2\u5c64\u306f\u90e8\u4f4d\u30fb\u5e74\u9f62\u30fb\u5b63\u7bc0\u3067\u6c34\u5206\u91cf\u304c\u9055\u3046\uff01<\/a><\/p>\n<p class=\"mg1\">\uff0a<a class=\"link\" href=\"https:\/\/www.nahls.co.jp\/eijingukea\/editorial_news\/model\/\" target=\"_blank\" rel=\"noopener\">\u30e2\u30c7\u30eb\u304c\u5b9f\u8df5\u3057\u3066\u3044\u308b\u7f8e\u808c\u30ad\u30fc\u30d7\u306e\u30b1\u30a2\u306f\u3084\u3063\u3071\u308a\u300c\u4fdd\u6e7f\u300d\uff1f\uff01<\/a><\/p>\n<h3 class=\"md3\">3\uff09\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u3068\u808c\u60a9\u307f\u306e\u95a2\u4fc2<\/h3>\n<p>\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u304c\u5c11\u306a\u304b\u3063\u305f\u308a\u3001\u7570\u5e38\u304c\u3042\u308b\u3068\u30d0\u30ea\u30a2\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u307e\u3059\u3002<\/p>\n<p class=\"mg1\">\u305d\u3046\u306a\u308b\u3068\u3001\u76ae\u819a\u5e38\u5728\u83cc\u30d0\u30e9\u30f3\u30b9\u304c\u5d29\u308c\u3001pH\u304c\u5f31\u9178\u6027\u304b\u3089\u30a2\u30eb\u30ab\u30ea\u6027\u306b\u50be\u304f\u3053\u3068\u3082\u3002<\/p>\n<p>\u305d\u306e\u7d50\u679c\u3001\u4e7e\u71e5\u808c\u3084\u654f\u611f\u808c\u3001\u808c\u8352\u308c\u306a\u3069\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<p class=\"mg1\">\u307e\u305f\u3001\u30d0\u30ea\u30a2\u6a5f\u80fd\u306e\u4f4e\u4e0b\u306f\u3001\u9854\u306e\u304f\u3059\u307f\u3084\u30a4\u30f3\u30ca\u30fc\u30c9\u30e9\u30a4\u808c\u306a\u3069\u3001\u3055\u307e\u3056\u307e\u306a\u808c\u60a9\u307f\u306e\u539f\u56e0\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"mg1 alignnone wp-image-49313 size-full\" src=\"https:\/\/www.nahls.co.jp\/eijingukea\/wp-content\/uploads\/2021\/07\/dc98101639ee507e2cd7028630f75995-e1626768138897.png\" alt=\"\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u304c\u6e1b\u5c11\u3059\u308b\u3053\u3068\u306b\u3088\u308b\u808c\u3078\u306e\u5f71\u97ff\u306e\u56f3\" width=\"600\" height=\"338\" \/><\/p>\n<p>\u3055\u3089\u306b\u3001\u6700\u8fd1\u3067\u306f\u89d2\u8cea\u7d30\u80de\u306e\u9762\u7a4d\u3084\u5f62\u72b6\u3068\u9854\u306e\u305f\u308b\u307f\u3084\u30b7\u30ef\u306a\u3069\u808c\u8001\u5316\u3068\u95a2\u4fc2\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n<p class=\"mg1\">\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u304c\u5c11\u306a\u3044\u3053\u3068\u3067\u3001\u3053\u3046\u3057\u305f\u30a8\u30a4\u30b8\u30f3\u30b0\u30b5\u30a4\u30f3\u306b\u3082\u60aa\u5f71\u97ff\u3092\u4e0e\u3048\u3066\u3044\u308b\u53ef\u80fd\u6027\u3082\u3042\u308a\u305d\u3046\u3067\u3059\u3002<\/p>\n<p class=\"mg1\">\u3053\u306e\u3088\u3046\u306b\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u306f\u3001\u30b3\u30fc\u30cb\u30d5\u30a1\u30a4\u30c9\u30a8\u30f3\u30d3\u30ed\u30fc\u30d7\uff08CE\uff09\u3084\u30bf\u30a4\u30c8\u30b8\u30e3\u30f3\u30af\u30b7\u30e7\u30f3\u306a\u3069\u3068\u540c\u3058\u304f\u3042\u307e\u308a\u77e5\u3089\u308c\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u808c\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u306e\u6b63\u5e38\u5316\u306b\u3068\u3066\u3082\u5927\u5207\u306a\u306e\u3067\u3059\u3002<\/p>\n<p>\uff1c\u53c2\u8003\u8a18\u4e8b\uff1e<\/p>\n<p class=\"mg2\">\uff0a<a class=\"link\" href=\"https:\/\/www.nahls.co.jp\/eijingukea\/editorial_news\/kakusousaibou\/\" target=\"_blank\" rel=\"noopener\">\u89d2\u5c64\u7d30\u80de\u304c\u9854\u306e\u305f\u308b\u307f\u3001\u30b7\u30ef\u306e\u5f62\u3092\u6c7a\u3081\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u305f\uff01<\/a><\/p>\n<hr class=\"sen\" \/>\n<h2 class=\"md2\">\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u3068\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e<\/h2>\n<p class=\"mg1\">\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u306f\u3001\u3082\u3068\u3082\u3068\u4f55\u3089\u304b\u306e\u30a2\u30ec\u30eb\u30b2\u30f3\u306b\u3088\u308b\u611f\u4f5c\u304c\u3042\u3063\u3066\u3001\u76ae\u819a\u306b\u30a2\u30ec\u30eb\u30ae\u30fc\u304c\u8d77\u3053\u308a\u3001\u76ae\u819a\u708e\u3092\u767a\u75c7\u3059\u308b\u3082\u306e\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<p class=\"mg1\">\u30a2\u30ec\u30eb\u30ae\u30fc\u306f\u514d\u75ab\u3068\u6df1\u3044\u304b\u304b\u308f\u308a\u304c\u3042\u308b\u305f\u3081\u3001\u6cbb\u7642\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u514d\u75ab\u306b\u5bfe\u3059\u308b\u5bfe\u7b56\u304c\u4e3b\u6d41\u3067\u3057\u305f\u3002<\/p>\n<p class=\"mg1\">\u307e\u305f\u3001\u304b\u3064\u3066\u306f\u305d\u306e\u307b\u304b\u306e\u8981\u56e0\u304c\u8907\u96d1\u306b\u7d61\u307f\u5408\u3063\u3066\u3044\u308b\u3053\u3068\u306f\u308f\u304b\u3063\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u4ee5\u5916\u306e\u5927\u304d\u306a\u30a4\u30f3\u30d1\u30af\u30c8\u3092\u4e0e\u3048\u308b\u8981\u56e0\u304c\u4f55\u304b\u3092\u89e3\u660e\u3059\u308b\u306b\u306f\u81f3\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<p class=\"mg1\">\u4e00\u65b9\u3001\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u3068\u76ae\u819a\u304c\u30ab\u30b5\u30ab\u30b5\u306e\u9c57\u72b6\u306b\u306a\u308b\u5c0b\u5e38\u6027\u9b5a\u9c57\u766c\u304c\u3057\u3070\u3057\u3070\u5408\u4f75\u3059\u308b\u3053\u3068\u306f\u3088\u304f\u77e5\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<p class=\"mg1\">\u5c0b\u5e38\u6027\u9b5a\u9c57\u766c\u306f\u3001\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u907a\u4f1d\u5b50\u7570\u5e38\u306b\u3088\u308b\u89d2\u5316\u7570\u5e38\u304c\u539f\u56e0\u3067\u3042\u308b\u3053\u3068\u304b\u3089\u3001\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u306b\u3082\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u907a\u4f1d\u5b50\u7570\u5e38\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<p class=\"mg1\">\u305d\u3046\u3057\u305f\u3053\u3068\u3092\u80cc\u666f\u306b\u3001\u6b27\u7c73\u3084\u65e5\u672c\u3067\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u60a3\u8005\u3055\u3093\u306b\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u907a\u4f1d\u5b50\u306e\u7570\u5e38\u304c\u3042\u308b\u304b\u3069\u3046\u304b\u306e\u8abf\u67fb\u7814\u7a76\u304c\u9032\u307f\u307e\u3057\u305f\u3002<\/p>\n<p>\u305d\u306e\u7d50\u679c\u3001\u6b27\u7c73\u3067\u306f40\uff05\u301c\u534a\u6570\u3001\u65e5\u672c\u4eba\u3067\u306f\u7d0420\u301c30\uff05\u306e\u65b9\u306b\u3001\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u907a\u4f1d\u5b50\u306e\u7570\u5e38\u304c\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u305f\u306e\u3067\u3059\u3002<\/p>\n<p class=\"mg1\">\u307e\u305f\u3001\u307b\u307c\u3059\u3079\u3066\u306e\u65b9\u3067\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u86cb\u767d\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>\u3064\u307e\u308a\u3001\u4e88\u60f3\u901a\u308a\u3001\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u306e\u907a\u4f1d\u5b50\u7570\u5e38\u304c\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u305f\u306e\u3067\u3059\u3002<\/p>\n<p class=\"mg1\">\u3053\u3046\u3057\u305f\u3053\u3068\u306b\u52a0\u3048\u3066\u3001\u3055\u307e\u3056\u307e\u306a\u7814\u7a76\u304c\u9032\u3093\u3060\u7d50\u679c\u3001\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u306e\u6210\u308a\u7acb\u3061\u3084\u6cbb\u7642\u306e\u8003\u3048\u65b9\u304c\u5909\u5316\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u306f\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u306e\u524d\u306b\u76ae\u819a\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u306e\u7570\u5e38\u304c\u307e\u305a\u3042\u3063\u3066\uff0c\u305d\u306e\u7d50\u679c\uff0c\u30a2\u30ec\u30eb\u30ae\u30fc\u611f\u4f5c\u304c\u8d77\u3053\u308a\u3084\u3059\u304f\u306a\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3001\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002<\/p>\n<p class=\"mg1\">\u305d\u306e\u305f\u3081\u3001\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u306e\u6cbb\u7642\u306f\u3001\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u5b88\u308b\u3053\u3068\u304c\u91cd\u8981\u8996\u3055\u308c\u59cb\u3081\u305f\u306e\u3067\u3059\u3002<\/p>\n<p class=\"mg1\">\u5177\u4f53\u7684\u306b\u306f\u3001\u6cbb\u7642\u306e\u9078\u629e\u80a2\u3068\u3057\u3066\u3001\u30ef\u30bb\u30ea\u30f3\u3084\u30d8\u30d1\u30ea\u30f3\u985e\u4f3c\u7269\u8cea\u306a\u3069\u533b\u85ac\u54c1\u306e\u4fdd\u6e7f\u5264\u306b\u3088\u3063\u3066\u3001\u30d0\u30ea\u30a2\u6a5f\u80fd\u306e\u6539\u5584\u3092\u56f3\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<p class=\"mg1\">\u307e\u305f\u3001\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u306b\u306a\u308a\u3084\u3059\u3044\u4e73\u5150\u306b\u3057\u3063\u304b\u308a\u3068\u4fdd\u6e7f\u30b1\u30a2\u3092\u884c\u3046\u3053\u3068\u3067\u3001\u767a\u75c7\u7387\u304c\u6e1b\u5c11\u3059\u308b\u3068\u3044\u3046\u7814\u7a76\u3082\u3042\u308b\u3053\u3068\u304b\u3089\u3001\u8d64\u3061\u3083\u3093\u306e\u9803\u304b\u3089\u30b9\u30ad\u30f3\u30b1\u30a2\u3092\u884c\u3046\u30a2\u30d7\u30ed\u30fc\u30c1\u306e\u91cd\u8981\u6027\u304c\u8a8d\u8b58\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3053\u3046\u3057\u305f\u3053\u3068\u304b\u3089\u3001\u73fe\u5728\u3067\u306f\u3001\u533b\u5b66\u7684\u306b\u3082\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u306e\u75c7\u72b6\u6539\u5584\u306b\u30b9\u30ad\u30f3\u30b1\u30a2\u304c\u91cd\u8981\u8996\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u306e\u3067\u3059\u3002<\/p>\n<p class=\"mg1\">\u307b\u304b\u306b\u3082\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u306f\u3001\u8001\u4eba\u6027\u4e7e\u76ae\u75c7\u3084\u3001\u654f\u611f\u808c\u306e\u65b9\u306a\u3069\u3067\u5c11\u306a\u3044\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p class=\"mg1\">\u3053\u3046\u3057\u305f\u80cc\u666f\u304b\u3089\u3001\u30d5\u30a3\u30a3\u30e9\u30b0\u30ea\u30f3\u3092\u5897\u3084\u3059\u30a8\u30a4\u30b8\u30b8\u30f3\u30b0\u30b1\u30a2\u5316\u7ca7\u54c1\u3084\u533b\u85ac\u54c1\u306e\u958b\u767a\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<div class=\"mg1\" style=\"background: #f5f5f5; padding: 5px; border: none; border-radius: 10px; -moz-border-radius: 10px; -webkit-border-radius: 10px;\">\n<p><b>\uff1c\u53c2\u7167\u6587\u732e\uff1e<\/b><\/p>\n<p>\u79cb\u5c71\u771f\u5fd7: \u5404\u79d1\u81e8\u5e8a\u306e\u30c8\u30d4\u30c3\u30af\u30b9: \u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u907a\u4f1d\u5b50\u5909\u7570\u3068\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e.<br \/>\n\u65e5\u672c\u533b\u5e2b\u4f1a\u96d1\u8a8c 2010; 138 \uff0812\uff09: 2536-2537\uff08\u7dcf\u8aac\uff09.<\/p>\n<\/div>\n<div class=\"mg1\" style=\"background: #f5f5f5; padding: 5px; border: none; border-radius: 10px; -moz-border-radius: 10px; -webkit-border-radius: 10px;\">\n<p><b>\uff1c\u53c2\u7167\u5143\uff1e<\/b><\/p>\n<p>\uff0a<a class=\"link\" href=\"https:\/\/www.med.nagoya-u.ac.jp\/derma\/research_atopic.html\" target=\"_blank\" rel=\"noopener\">\u540d\u53e4\u5c4b\u5927\u5b66\u533b\u5b66\u90e8\u76ae\u819a\u79d1\u300c\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u306e\u767a\u75c7\u56e0\u5b50\u30fb\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u907a\u4f1d\u5b50\u5909\u7570\u300d<\/a><\/p>\n<p>\uff0a<a class=\"link\" href=\"https:\/\/hc.mochida.co.jp\/skincare\/atopic\/atopic6.html\" target=\"_blank\" rel=\"noopener\">\u6301\u7530\u88fd\u85ac\u682a\u5f0f\u4f1a\u793e\u3000\u30a2\u30c8\u30d4\u30fc\u808c\u30fb\u4e7e\u71e5\u808c\u30fb\u654f\u611f\u808c<\/a><\/p>\n<\/div>\n<p>\uff1c\u53c2\u8003\u8a18\u4e8b\uff1e<\/p>\n<p>\uff0a<a class=\"link\" href=\"https:\/\/www.nahls.co.jp\/eijingukea\/nayami\/kansou-hada\/kodomo\/\" target=\"_blank\" rel=\"noopener\">\u5b50\u4f9b\u30fb\u8d64\u3061\u3083\u3093\u306e\u4e7e\u71e5\u808c\u5bfe\u7b56\u306f\u6b63\u3057\u3044\u4fdd\u6e7f\u3067\uff01NG\u306b\u6ce8\u610f<\/a><\/p>\n<p>\uff0a<a class=\"link\" href=\"https:\/\/www.nahls.co.jp\/eijingukea\/nayami\/kansou-hada\/koureisha\/\" target=\"_blank\" rel=\"noopener\">\u9ad8\u9f62\u306e\u65b9\u306e\u4e7e\u71e5\u808c\u3068\u808c\u30c8\u30e9\u30d6\u30eb\uff01\u539f\u56e0\u3068\u5bfe\u7b56\u30fb\u6cbb\u7642\u306f\uff1f<\/a><\/p>\n<p class=\"mg2\">\uff0a<a class=\"link\" href=\"https:\/\/www.nahls.co.jp\/eijingukea\/nayami\/kansou-hada\/body\/\" target=\"_blank\" rel=\"noopener\">\u30dc\u30c7\u30a3\u306e\u4e7e\u71e5\u808c\u5bfe\u7b56\u3082\u5927\u5207\uff01\u304b\u3089\u3060\u306e\u4fdd\u6e7f\u30b1\u30a2\u3092<\/a><\/p>\n<hr class=\"sen\" \/>\n<h2 class=\"md2\">\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u3092\u5897\u3084\u3059\u5316\u7ca7\u54c1\u6210\u5206<\/h2>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"mg1 alignnone wp-image-32111\" src=\"https:\/\/www.nahls.co.jp\/eijingukea\/wp-content\/uploads\/2020\/01\/3f6186de358bfdb72ffeb0f90dc08e6a_s.jpg\" alt=\"\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u3092\u5897\u3084\u3059\u5316\u7ca7\u54c1\u6210\u5206\u306e\u30a4\u30e1\u30fc\u30b8\" width=\"400\" height=\"267\" \/><\/p>\n<h3 class=\"md3\">1\uff09\u30a4\u30f3\u30c1\u30f3\u30b3\u30a6\u30a8\u30ad\u30b9\u3068\u30ab\u30ef\u30e9\u30e8\u30e2\u30ae\u82b1\u30a8\u30ad\u30b9<\/h3>\n<p class=\"mg1\">\u4f50\u85e4\u88fd\u85ac\u682a\u5f0f\u4f1a\u793e\u306e\u7814\u7a76\u3067\u3001\u30a4\u30f3\u30c1\u30f3\u30b3\u30a6\u30a8\u30ad\u30b9\u304c\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u907a\u4f1d\u5b50\u767a\u73fe\u4fc3\u9032\u4f5c\u7528\u3092\u6301\u3064\u3053\u3068\u304c\u767a\u8868\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u30a4\u30f3\u30c1\u30f3\u30b3\u30a6\u30a8\u30ad\u30b9\u3068\u306f\u3001\u30ad\u30af\u79d1\u690d\u7269\u3067\u3042\u308b\u30ab\u30ef\u30e9\u30e8\u30e2\u30ae\u306e\u6210\u719f\u3057\u305f\u982d\u82b1\u3092\u4e7e\u71e5\u3055\u305b\u3066\u5f97\u3089\u308c\u308b\u751f\u85ac\u3067\u3059\u3002<\/p>\n<p class=\"mg1\">\u4f3c\u305f\u5316\u7ca7\u54c1\u6210\u5206\u3068\u3057\u3066\u3001\u30ab\u30ef\u30e9\u30e8\u30e2\u30ae\u82b1\u30a8\u30ad\u30b9\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<div class=\"mg1\" style=\"background: #f5f5f5; padding: 5px; border: none; border-radius: 10px; -moz-border-radius: 10px; -webkit-border-radius: 10px;\">\n<p><b>\uff1c\u53c2\u7167\u5143\uff1e<\/b><br \/>\n\uff0a<a class=\"link\" href=\"https:\/\/www.sato-seiyaku.co.jp\/newsrelease\/2015\/150824\/\" target=\"_blank\" rel=\"noopener\">\u4f50\u85e4\u88fd\u85ac\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u300c\u30a4\u30f3\u30c1\u30f3\u30b3\u30a6\u30a8\u30ad\u30b9\u306b\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u767a\u73fe\u4fc3\u9032\u4f5c\u7528\u3092\u78ba\u8a8d\u300d<\/a><\/p>\n<\/div>\n<h3 class=\"md3\">2\uff09\u30b5\u30ac\u30e9\u30e1\u30a8\u30ad\u30b9\u3068\u30de\u30f3\u30c0\u30ea\u30f3\u30aa\u30ec\u30f3\u30b8\u679c\u76ae\u30a8\u30ad\u30b9<\/h3>\n<p class=\"mg1\">\u30d4\u30b8\u30e7\u30f3\u682a\u5f0f\u4f1a\u793e\u306e\u7814\u7a76\u3067\u3001\u30b5\u30ac\u30e9\u30e1\u30a8\u30ad\u30b9\u304a\u3088\u3073\u30de\u30f3\u30c0\u30ea\u30f3\u30aa\u30ec\u30f3\u30b8\u679c\u76ae\u30a8\u30ad\u30b9\u306e\u6df7\u5408\u7269\u3092\u914d\u5408\u3057\u305f\u30b9\u30ad\u30f3\u30b1\u30a2\u88fd\u54c1\u306b\u304a\u3044\u3066\u3001\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u4fc3\u9032\u52b9\u679c\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n<p class=\"mg1\">\u30de\u30f3\u30c0\u30ea\u30f3\u30aa\u30ec\u30f3\u30b8\u679c\u76ae\u30a8\u30ad\u30b9\u306f\u3001\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u5206\u89e3\u9175\u7d20\u306e\u7523\u751f\u4fc3\u9032\u4f5c\u7528\u306b\u3088\u3063\u3066\u3001\u5929\u7136\u4fdd\u6e7f\u56e0\u5b50\uff08NMF\uff09\u3092\u5897\u3084\u3059\u4f5c\u7528\u304c\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<div class=\"mg1\" style=\"background: #f5f5f5; padding: 5px; border: none; border-radius: 10px; -moz-border-radius: 10px; -webkit-border-radius: 10px;\">\n<p><b>\uff1c\u53c2\u7167\u5143\uff1e<\/b><br \/>\n\uff0a<a class=\"link\" href=\"https:\/\/www.shinryo-to-shinyaku.com\/db\/pdf\/sin_0057_03_0239.pdf\" target=\"_blank\" rel=\"noopener\">\u30b5\u30ac\u30e9\u30e1\u30a8\u30ad\u30b9\u304a\u3088\u3073\u30de\u30f3\u30c0\u30ea\u30f3\u30aa\u30ec\u30f3\u30b8\u679c\u76ae\u30a8\u30ad\u30b9\u3092\u914d\u5408\u3057\u305f\u5316\u7ca7\u54c1\u306b\u3088\u308b\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u4fc3\u9032\u52b9\u679c\u306e\u691c\u8a3c<\/a><\/p>\n<\/div>\n<h3 class=\"md3\">3\uff09\u30c7\u30d5\u30a7\u30ea\u30d5\u30a7\u30ea\u30af\u30ea\u30b7\u30f3<\/h3>\n<p class=\"mg1\">\u6708\u6842\u51a0\u7dcf\u5408\u7814\u7a76\u6240\u306f\u3001\u65e5\u672c\u9152\u3001\u9152\u7c95\u306a\u3069\u306b\u542b\u307e\u308c\u308b\u30da\u30d7\u30c1\u30c9\u3067\u3042\u308b\u30c7\u30d5\u30a7\u30ea\u30d5\u30a7\u30ea\u30af\u30ea\u30b7\u30f3\u304c\u3001\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u3092\u5897\u3084\u3059\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002<\/p>\n<div class=\"mg1\" style=\"background: #f5f5f5; padding: 5px; border: none; border-radius: 10px; -moz-border-radius: 10px; -webkit-border-radius: 10px;\">\n<p><b>\uff1c\u53c2\u7167\u5143\uff1e<\/b><br \/>\n\uff0a<a class=\"link\" href=\"https:\/\/www.gekkeikan.co.jp\/company\/news\/detail\/223\/\" target=\"_blank\" rel=\"noopener\">\u6708\u6842\u51a0\u7dcf\u5408\u7814\u7a76\u6240\u3000\u9eb9\u83cc\u304c\u4f5c\u308b\u6210\u5206\u306b\u76ae\u819a\u30d0\u30ea\u30a2\u6539\u5584\u30fb\u4fdd\u6e7f\u6a5f\u80fd\u767a\u898b\u3000\u30c7\u30d5\u30a7\u30ea\u30d5\u30a7\u30ea\u30af\u30ea\u30b7\u30f3\u306b\u3088\u308b\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u306e\u751f\u7523\u4fc3\u9032<\/a><\/p>\n<\/div>\n<p class=\"mg1\">\u3053\u308c\u3089\u4ee5\u5916\u3067\u3082\u3001\u8102\u6eb6\u6027\u30d3\u30bf\u30df\u30f3\uff226\u306e\u8a98\u5c0e\u4f53\u30c8\u30ea\u30b9\u30d8\u30ad\u30b7\u30eb\u30c7\u30ab\u30f3\u9178\u30d4\u30ea\u30c9\u30ad\u30b7\u30f3\u306b\u3082\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u3092\u5897\u3084\u3059\u306f\u305f\u3089\u304d\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\uff1c\u672c\u8a18\u4e8b\u5168\u822c\u306e\u53c2\u8003\u66f8\u7c4d\uff1e<\/p>\n<p>\uff0a<a class=\"link\" href=\"https:\/\/www.nahls.co.jp\/eijingukea\/bookreview\/hifukagaku\/\" target=\"_blank\" rel=\"noopener\">\u3042\u305f\u3089\u3057\u3044\u76ae\u819a\u79d1\u5b66\u7b2c3\u7248\uff08\u6e05\u6c34\u5b8f\u3000\u8457\u3001\u4e2d\u5c71\u66f8\u5e97\u30012018\u5e742\u6708\uff09\u300d<\/a><\/p>\n<p class=\"mg2\">\uff0a<a class=\"link\" href=\"https:\/\/www.nahls.co.jp\/eijingukea\/bookreview\/hifukaikoushohin\/\" target=\"_blank\" rel=\"noopener\">\u300c\u76ae\u819a\u79d1\u533b\u306e\u305f\u3081\u306e\u9999\u7ca7\u54c1\u5165\u9580\u300d(\u3014\u76ae\u819a\u79d1\u306e\u81e8\u5e8a 2014\u5e7410\u6708\u81e8\u6642\u5897\u520a\u53f7[56\u5dfb11\u53f7] \u3015\u91d1\u539f\u51fa\u7248\u682a\u5f0f\u4f1a\u793e)<\/a><\/p>\n<hr class=\"sen\" \/>\n<h2 class=\"md2\">\u307e\u3068\u3081<\/h2>\n<p>\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u3068\u306f\u4f55\u304b\u3001\u307e\u305f\u305d\u306e\u306f\u305f\u3089\u304d\u3092\u3054\u7d39\u4ecb\u3057\u307e\u3057\u305f\u3002<\/p>\n<p class=\"mg1\">\u3044\u304b\u304c\u3060\u3063\u305f\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n<p>\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u306f\u3001\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u306e\u904e\u7a0b\u3067\u3067\u304d\u308b\u305f\u3093\u3071\u304f\u8cea\u3067\u3059\u3002<\/p>\n<p class=\"mg1\">\u6700\u7d42\u7684\u306b\u30a2\u30df\u30ce\u9178\u306b\u5206\u89e3\u3055\u308c\u3066\u5929\u7136\u4fdd\u6e7f\u56e0\u5b50\uff08NMF\uff09\u306e\u4e3b\u6210\u5206\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>\u3064\u307e\u308a\u3001\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u5b88\u308b\u305f\u3081\u306b\u3068\u3066\u3082\u5927\u5207\u306a\u6210\u5206\u3067\u3059\u3002<\/p>\n<p class=\"mg1\">\u307e\u305f\u3001\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u3068\u6df1\u3044\u95a2\u4fc2\u304c\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n<p class=\"mg1\">\u305c\u3072\u3001\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u306b\u3064\u3044\u3066\u7406\u89e3\u3092\u6df1\u3081\u3001\u5065\u3084\u304b\u306a\u7f8e\u808c\u306e\u305f\u3081\u306b\u6d3b\u304b\u3057\u3066\u304f\u3060\u3055\u3044\u306d\u3002<\/p>\n<p class=\"mg1\">\u3053\u306e\u8a18\u4e8b\u300c\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u306f\u808c\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u306b\u5927\u5207\uff01\u5929\u7136\u4fdd\u6e7f\u56e0\u5b50\u306e\u6e90\u300d\u304c\u3001\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u4e16\u4ee3\u306e\u5973\u6027\u306e\u304a\u5f79\u306b\u7acb\u3066\u3070\u5e78\u3044\u3067\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>\uff1c\u53c2\u7167\u8ad6\u6587\uff1e<\/h2>\n<p><cite><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16550169\/?utm_source=chatgpt.com\" target=\"_blank\" rel=\"noopener\">\u30101\u3011Palmer CN, Irvine AD, Terron-Kwiatkowski A, Zhao Y, Liao H, Lee SP, et al. Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet. 2006 Apr;38(4):441-6.<\/a><br \/>\n<\/cite>PMID: 16550169\uff5cDOI: 10.1038\/ng1767<br \/>\n<strong>\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\uff08FLG\uff09\u6a5f\u80fd\u6b20\u640d\u5909\u7570\u304c\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u4ee3\u8868\u8ad6\u6587\u3002\u8a18\u4e8b\u306e\u300c\u30d0\u30ea\u30a2\u6a5f\u80fd\u4f4e\u4e0b\u3068\u75be\u60a3\u300d\u306e\u6839\u62e0\u306b\u5bfe\u5fdc\u3002<\/p>\n<p><cite><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16444271\/?utm_source=chatgpt.com\" target=\"_blank\" rel=\"noopener\">\u30102\u3011Smith FJD, Irvine AD, Terron-Kwiatkowski A, Sandilands A, Campbell LE, Zhao Y, et al. Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris. Nat Genet. 2006 Mar;38(3):337-42.<\/a><br \/>\n<\/cite>PMID: 16444271\uff5cDOI: 10.1038\/ng1743<br \/>\n<strong>\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>FLG\u5909\u7570\u304c\u5c0b\u5e38\u6027\u9b5a\u9c57\u766c\u306e\u539f\u56e0\u3068\u306a\u308b\u3053\u3068\u3092\u793a\u3057\u3001\u89d2\u5316\u30fb\u4e7e\u71e5\u306e\u75c5\u614b\u306b\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u304c\u91cd\u8981\u3068\u793a\u5506\u3002\u8a18\u4e8b\u306e\u300c\u4e7e\u71e5\u30fb\u89d2\u8cea\u7570\u5e38\u300d\u89e3\u8aac\u306b\u5bfe\u5fdc\u3002<\/p>\n<p><cite><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18305568\/?utm_source=chatgpt.com\" target=\"_blank\" rel=\"noopener\">\u30103\u3011Kezic S, Kemperman PMJH, Koster ES, de Jongh CM, Thio HB, Campbell LE, et al. Loss-of-function mutations in the filaggrin gene lead to reduced level of natural moisturizing factor in the stratum corneum. J Invest Dermatol. 2008 Aug;128(8):2117-9.<\/a><\/cite><br \/>\nPMID: 18305568\uff5cDOI: 10.1038\/jid.2008.29<br \/>\n<strong>\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>FLG\u6a5f\u80fd\u4f4e\u4e0b\u3067\u89d2\u8cea\u5c64\u306e\u5929\u7136\u4fdd\u6e7f\u56e0\u5b50\uff08NMF\uff09\u304c\u6e1b\u308b\u3053\u3068\u3092\u5b9f\u8a3c\u3002\u8a18\u4e8b\u306e\u300cNMF\u306e\u6e90\uff1d\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u5206\u89e3\u7523\u7269\u300d\u8aac\u660e\u306b\u5bfe\u5fdc\u3002<\/p>\n<p><cite><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21654840\/?utm_source=chatgpt.com\" target=\"_blank\" rel=\"noopener\">\u30104\u3011Hoste E, Kemperman P, Devos M, Denecker G, Kezic S, Yau N, et al. Caspase-14 is required for filaggrin degradation to natural moisturizing factors in the skin. J Invest Dermatol. 2011 Nov;131(11):2233-41.<\/a><br \/>\n<\/cite>PMID: 21654840\uff5cDOI: 10.1038\/jid.2011.153<br \/>\n<strong>\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u30ab\u30b9\u30d1\u30fc\u30bc14\u304c\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u5206\u89e3\u3068NMF\u7523\u751f\u306b\u5fc5\u9808\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u7814\u7a76\u3002\u8a18\u4e8b\u306e\u300cNMF\u751f\u6210\u30d7\u30ed\u30bb\u30b9\u300d\u88dc\u5f37\u306b\u5bfe\u5fdc\u3002<\/p>\n<p><cite><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19386895\/?utm_source=chatgpt.com\" target=\"_blank\" rel=\"noopener\">\u30105\u3011Sandilands A, Sutherland C, Irvine AD, McLean WHI. Filaggrin in the frontline: role in skin barrier function and disease. 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Dev Biol. 1986 May;115(1):84-92.<\/a><br \/>\n<\/cite>PMID: 3516761\uff5cDOI: 10.1016\/0012-1606(86)90230-7<br \/>\n<strong>\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u74b0\u5883\u306e\u6c34\u5206\u6761\u4ef6\u304c\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u5206\u89e3\u3068\u5438\u6c34\u6027\u6210\u5206\u751f\u6210\u306b\u5f71\u97ff\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u57fa\u790e\u7814\u7a76\u3002\u8a18\u4e8b\u306e\u300c\u4fdd\u6e7f\u74b0\u5883\u306e\u91cd\u8981\u6027\u300d\u306e\u6839\u62e0\u3002<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30d5\u30a3\u30e9\u30b0\u30ea\u30f3\u306f\u8868\u76ae\u306e\u89d2\u5c64\u306e\u7d30\u80de\u3092\u3064\u304f\u308b\u305f\u3093\u3071\u304f\u8cea\u3002\u5206\u89e3\u3055\u308c\u308b\u3068\u5929\u7136\u4fdd\u6e7f\u56e0\u5b50\uff08NMF\uff09\u3068\u306a\u3063\u3066\u3001\u808c\u306e\u30d0 [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":49938,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[246],"tags":[1818,86,1817,109,2548],"aioseo_notices":[],"_links":{"self":[{"href":"\/eijingukea\/index.php\/wp-json\/wp\/v2\/posts\/49256"}],"collection":[{"href":"\/eijingukea\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/eijingukea\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/eijingukea\/index.php\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"\/eijingukea\/index.php\/wp-json\/wp\/v2\/comments?post=49256"}],"version-history":[{"count":21,"href":"\/eijingukea\/index.php\/wp-json\/wp\/v2\/posts\/49256\/revisions"}],"predecessor-version":[{"id":77090,"href":"\/eijingukea\/index.php\/wp-json\/wp\/v2\/posts\/49256\/revisions\/77090"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/eijingukea\/index.php\/wp-json\/wp\/v2\/media\/49938"}],"wp:attachment":[{"href":"\/eijingukea\/index.php\/wp-json\/wp\/v2\/media?parent=49256"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/eijingukea\/index.php\/wp-json\/wp\/v2\/categories?post=49256"},{"taxonomy":"post_tag","embeddable":true,"href":"\/eijingukea\/index.php\/wp-json\/wp\/v2\/tags?post=49256"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}