{"id":65665,"date":"2026-01-06T14:10:41","date_gmt":"2026-01-06T05:10:41","guid":{"rendered":"https:\/\/www.nahls.co.jp\/eijingukea\/?p=65665"},"modified":"2026-01-06T14:29:19","modified_gmt":"2026-01-06T05:29:19","slug":"gura_nahlspure","status":"publish","type":"post","link":"https:\/\/www.nahls.co.jp\/eijingukea\/evidences\/hiroba\/gura_nahlspure\/","title":{"rendered":"\u300c\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u300d\u3092\u4f7f\u3063\u3066\u307f\u307e\u3057\u305f\u2606by gura"},"content":{"rendered":"
\n

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\n\u25a0\u5bb9\u91cf\u3000120ml<\/span>
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\n————————————<\/span><\/p>\n

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\n\u2611\u754c\u9762\u6d3b\u6027\u5264\u30d5\u30ea\u30fc<\/p>\n

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\"\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\"<\/a><\/p>\n

 <\/p>\n

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\n\u7121\u9999\u6599\u3067\u3059\u3002<\/p>\n

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\n\u523a\u6fc0\u3082\u306a\u304f\u4f7f\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n

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\n\u5316\u7ca7\u6c34\u3060\u3051\u3067\u3001<\/p>\n

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\n\u2611\u4fdd\u6e7f<\/p>\n

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\u3060\u304b\u3089\u3001gura\u3055\u3093\u3082\u4ef0\u308b\u3088\u3046\u306b\u30a8\u30a4\u30b8\u30f3\u30b0\u304c\u6c17\u306b\u306a\u308b\u65b9\u306b\u306f\u3001\u305c\u3072\u4e00\u5ea6\u624b\u306b\u53d6\u3063\u3066\u3044\u305f\u3060\u3051\u305f\u3089\u3068\u601d\u3044\u307e\u3059\u3002\u304d\u3063\u3068\u3053\u306e\u300c\u300c\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u300d\u3092\u4f7f\u3063\u3066\u307f\u307e\u3057\u305f\u300d\u306e\u8a18\u4e8b\u304c\u3001\u30ca\u30fc\u30eb\u30b9\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u30a2\u30ab\u30c7\u30df\u30fc\u306e\u8aad\u8005\u306e\u307f\u306a\u3055\u307e\u306e\u304a\u5f79\u306b\u7acb\u3064\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n

 <\/p>\n

\uff1c\u53c2\u7167\u8ad6\u6587\uff1e<\/h2>\n
\r\n\u30101\u3011\u6e6f\u6d45\uff08\u5c0f\u5cf6\uff09\u660e\u5b50, \u6797\u7db8\u5b50, \u97d3\u7acb\u53cb, \u6e21\u8fba\u6587\u592a, \u5e73\u7af9\u6f64.\u03b3-\u30b0\u30eb\u30bf\u30df\u30eb\u30c8\u30e9\u30f3\u30b9\u30da\u30d7\u30c1\u30c0\u30fc\u30bc\uff08GGT\uff09\u963b\u5bb3\u5264\u306b\u3088\u308b\u30b3\u30e9\u30fc\u30b2\u30f3\u304a\u3088\u3073\u30a8\u30e9\u30b9\u30c1\u30f3\u7523\u751f\u80fd\u306e\u4ea2\u9032\u52b9\u679c\u3068\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0.\u65e5\u672c\u9999\u7ca7\u54c1\u5b66\u4f1a\u8a8c. Vol.36, No.2, 93\u2013100, 2012.<\/a><\/cite>
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8:<\/strong>\u672c\u7814\u7a76\u3067\u306f\u3001\u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\u00ae\u306e\u57fa\u3068\u306a\u308b\u03b3-\u30b0\u30eb\u30bf\u30df\u30eb\u30c8\u30e9\u30f3\u30b9\u30da\u30d7\u30c1\u30c0\u30fc\u30bc\uff08GGT\uff09\u963b\u5bb3\u5264\u304c\u30d2\u30c8\u76ae\u819a\u7dda\u7dad\u82bd\u7d30\u80de\u306b\u4f5c\u7528\u3057\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u304a\u3088\u3073\u30a8\u30e9\u30b9\u30c1\u30f3\u306e\u7523\u751f\u3092\u4fc3\u9032\u3059\u308b \u6a5f\u5e8f\u306b\u3064\u3044\u3066\u89e3\u6790\u3057\u305f\u3002\u5b9f\u9a13\u7d50\u679c\u3068\u3057\u3066\u3001GGT\u963b\u5bb3\u304c\u7dda\u7dad\u82bd\u7d30\u80de\u306e\u8ce6\u6d3b\u306b\u3064\u306a\u304c\u308a\u3001\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u306b\u5bc4\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u305f\u3002\u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\u306e \u5316\u7ca7\u54c1\u539f\u6599\u3068\u3057\u3066\u306e\u4f5c\u7528\u6a5f\u5e8f\u306e\u79d1\u5b66\u7684\u6839\u62e0 \u3092\u63d0\u4f9b\u3059\u308b\u91cd\u8981\u306a\u5b66\u8853\u8ad6\u6587\u3002
\r\n\r\n\u30102\u3011Bissett DL, Oblong JE, Berge CA.Niacinamide: A B vitamin that improves aging facial skin appearance.Dermatol Surg. 2005;31(7 Pt 2):860\u2013865.<\/a><\/cite>
\r\n\r\nPMID: 16029679\u3000DOI: 10.1111\/j.1524-4725.2005.31726
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u5916\u7528\u306b\u3088\u308a\u3001\u5c0f\u3058\u308f\u3001\u8272\u30e0\u30e9\u3001\u9ec4\u3050\u3059\u307f\u3001\u30d0\u30ea\u30a2\u6a5f\u80fd\u304c\u6539\u5584\u3002\u30bb\u30e9\u30df\u30c9\u5408\u6210\u4fc3\u9032\u3084\u708e\u75c7\u6291\u5236\u3092\u901a\u3058\u3066\u3001\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u3068\u7f8e\u767d\u306e\u4e21\u9762\u3067\u6709\u7528\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u4ee3\u8868\u7684\u7814\u7a76\u3002
\r\n\r\n\u30103\u3011Pullar JM, Carr AC, Vissers MCM.The Roles of Vitamin C in Skin Health.Nutrients. 2017;9(8):866.<\/a><\/cite>
\r\n\r\nPMID: 28805671DOI: 10.3390\/nu9080866
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u30d3\u30bf\u30df\u30f3C\u306f\u30b3\u30e9\u30fc\u30b2\u30f3\u5408\u6210\u3001\u6297\u9178\u5316\u3001\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u6291\u5236\u306b\u95a2\u4e0e\u3059\u308b\u91cd\u8981\u6210\u5206\u3002\u5916\u7528\u30d3\u30bf\u30df\u30f3C\u304a\u3088\u3073\u8a98\u5c0e\u4f53\u304c\u3001\u5149\u8001\u5316\u3084\u30b7\u30df\u5bfe\u7b56\u306b\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u3092\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u6574\u7406\u3057\u305f\u7dcf\u8aac\u3002
\r\n\r\n\u30104\u3011Bai X-D, Liu Y-C, Ge S-Y, Fei W-C.Clinical Trial of Salmon Nasal Cartilage-Derived Proteoglycans on Human Facial Antiaging: A Randomized, Double-Blind, Placebo-Controlled Study.J Cosmet Dermatol. 2025 Jul;24(7):e70218.<\/a><\/cite>
\r\n\r\nPMID: 40613544 DOI: 10.1111\/jocd.70218
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u30b5\u30b1\u9f3b\u8edf\u9aa8\u7531\u6765\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u309256\u65e5\u9593\u6442\u53d6\u3057\u305f\u4e8c\u91cd\u76f2\u691cRCT\u3002\u30d7\u30e9\u30bb\u30dc\u6bd4\u3067\u808c\u306e\u5f3e\u529b\u30fb\u6c34\u5206\u304c\u6539\u5584\u3057\u3001\u7c97\u3055\u30fb\u3057\u308f\u30fb\u30e1\u30e9\u30cb\u30f3\u91cf\u30fb\u30d6\u30e9\u30a6\u30f3\u30b9\u30dd\u30c3\u30c8\u304c\u6e1b\u5c11\u3002\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u306e\u201c\u808c\u30b3\u30f3\u30c7\u30a3\u30b7\u30e7\u30f3\u6539\u5584\u201d\u6839\u62e0\u3068\u3057\u3066\u4f7f\u3044\u3084\u3059\u3044\u3002
\r\n\r\n\u30105<\/cite>\u3011Rawlings AV, Harding CR.Moisturization and skin barrier function.Dermatol Ther. 2004;17 Suppl 1:43\u201348.<\/cite><\/a>
\r\n\r\nPMID: 14728698 DOI: 10.1111\/j.1396-0296.2004.04s1005.x
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u89d2\u8cea\u5c64\u306e\u4fdd\u6e7f\u3068\u30d0\u30ea\u30a2\u6a5f\u80fd\u306e\u7dcf\u8aac\u3002NMF\uff08PCA\u306a\u3069\u306e\u30a2\u30df\u30ce\u9178\u7531\u6765\u6210\u5206\uff09\u3084\u7d30\u80de\u9593\u8102\u8cea\u304c\u6c34\u5206\u4fdd\u6301\u306b\u91cd\u8981\u3067\u3001\u5316\u7ca7\u6c34\u30fb\u4fdd\u6e7f\u5264\u306f\u300c\u6c34\u3092\u4e0e\u3048\u308b\u300d\u3060\u3051\u3067\u306a\u304f\u300c\u4fdd\u6301\u3067\u304d\u308b\u89d2\u8cea\u74b0\u5883\u3092\u4f5c\u308b\u300d\u8a2d\u8a08\u304c\u8981\u70b9\u3068\u6574\u7406\u3002
\r\n\r\n\u30106\u3011Draelos ZD.The science behind skin care: Moisturizers.J Cosmet Dermatol. 2018;17(2):138\u2013144.<\/a><\/cite>
\r\n\r\nPMID: 29319217 DOI: 10.1111\/jocd.12490
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u4fdd\u6e7f\u5264\uff08\u5316\u7ca7\u6c34\uff5e\u4e73\u6db2\u30fb\u30af\u30ea\u30fc\u30e0\u542b\u3080\uff09\u306e\u79d1\u5b66\u3092\u6574\u7406\u3002\u30d2\u30e5\u30fc\u30e1\u30af\u30bf\u30f3\u30c8\uff08\u30b0\u30ea\u30bb\u30ea\u30f3\u7b49\uff09\uff0b\u30a8\u30e2\u30ea\u30a8\u30f3\u30c8\uff0b\u30aa\u30af\u30eb\u30fc\u30b7\u30d6\u306e\u7d44\u307f\u5408\u308f\u305b\u3001\u523a\u6fc0\u6027\u3001\u808c\u72b6\u614b\u306b\u5408\u308f\u305b\u305f\u9078\u629e\u304c\u91cd\u8981\u3067\u3001\u201c\u5316\u7ca7\u6c34\u9078\u3073\u306e\u8ef8\uff08\u4fdd\u6e7f\u30fb\u30d0\u30ea\u30a2\u30fb\u523a\u6fc0\uff09\u201d\u306e\u6839\u62e0\u306b\u306a\u308b\u3002
\r\n\r\n\u30107\u3011Verdier-S\u00e9vrain S, Bont\u00e9 F.Skin hydration: a review on its molecular mechanisms.J Cosmet Dermatol. 2007 Jun;6(2):75\u201382.<\/a><\/cite>
\r\n\r\nPMID: 17524122 DOI: 10.1111\/j.1473-2165.2007.00300.x
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u76ae\u819a\u306e\u3046\u308b\u304a\u3044\u306f\u89d2\u8cea\u306e\u69cb\u9020\u30fbNMF\u30fb\u8102\u8cea\u30fb\u6c34\u5206\u79fb\u52d5\u304c\u9023\u52d5\u3057\u3066\u7dad\u6301\u3055\u308c\u308b\u3068\u89e3\u8aac\u3002\u7279\u306b\u30b0\u30ea\u30bb\u30ea\u30f3\u306a\u3069\u306e\u4fdd\u6e7f\u56e0\u5b50\u306e\u91cd\u8981\u6027\u3001\u4e7e\u71e5\u3067\u843d\u5c51\u304c\u9032\u3080\u6a5f\u5e8f\u3092\u6574\u7406\u3057\u3001\u201c\u3046\u308b\u304a\u3044\u3092\u4fdd\u3064\u5316\u7ca7\u6c34\u30fb\u4fdd\u6e7f\u8a2d\u8a08\u201d\u306e\u7406\u8ad6\u80cc\u666f\u3068\u3057\u3066\u5f15\u7528\u3057\u3084\u3059\u3044\u3002
\r\n\r\n\u30108\u3011Zirwas MJ, Stechschulte SA.Moisturizer Allergy: Diagnosis and Management.J Clin Aesthet Dermatol. 2008 Nov;1(4):38\u201344.<\/a><\/cite>
\r\n\r\nPMID: 21212847 PMCID: PMC3016930
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u4fdd\u6e7f\u88fd\u54c1\uff08\u30b9\u30ad\u30f3\u30b1\u30a2\u5916\u7528\uff09\u306e\u523a\u6fc0\u30fb\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u63a5\u89e6\u76ae\u819a\u708e\uff08ACD\uff09\u306e\u539f\u56e0\u6210\u5206\u3092\u6574\u7406\u3057\u305f\u8ad6\u6587\u3002\u5e02\u8ca9\u4fdd\u6e7f\u88fd\u54c1\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u89e3\u6790\u3067\u306f\u3001\u9999\u6599\uff08fragrance\uff09\u304c\u6700\u3082\u591a\u3044\u30a2\u30ec\u30eb\u30b2\u30f3\u3067\u3001\u9999\u6599\u3092\u542b\u3080\u88fd\u54c1\u304c\u591a\u6570\u3092\u5360\u3081\u305f\u3002\u307e\u305f\u300c\u7121\u9999\u6599\u300d\u3092\u9078\u3093\u3067\u3082\u3001\u7cbe\u6cb9\u30fb\u751f\u7269\u7531\u6765\u6dfb\u52a0\u7269\u30fb\u30d9\u30f3\u30b8\u30eb\u30a2\u30eb\u30b3\u30fc\u30eb\u7b49\u306e\u201c\u9999\u6599\u95a2\u9023\u201d\u6210\u5206\u304c\u542b\u307e\u308c\u5f97\u308b\u70b9\u3092\u6307\u6458\u3057\u3001\u9999\u6599\u30a2\u30ec\u30eb\u30ae\u30fc\u3084\u654f\u611f\u808c\u3067\u306f\u3001\u771f\u306e\u7121\u9999\u6599\uff08fragrance-free\uff09\u201d\u3092\u9078\u3076\u3053\u3068\u304c\u5b89\u5168\u6027\u4e0a\u91cd\u8981\u3068\u793a\u5506\u3057\u3066\u3044\u308b\u3002\u672c\u8ad6\u6587\u306f\u5316\u7ca7\u6c34\u305d\u306e\u3082\u306e\u306e\u8a66\u9a13\u3067\u306f\u306a\u3044\u304c\u3001\u5316\u7ca7\u6c34\u3082\u540c\u3058\u304f\u300c\u9999\u308a\u4ed8\u3051\u300d\u3084\u9999\u6599\u95a2\u9023\u6210\u5206\u3092\u542b\u3080\u3053\u3068\u304c\u3042\u308a\u3001\u7121\u9999\u6599\u5316\u7ca7\u6c34\uff1d\u9999\u6599\u306b\u3088\u308b\u523a\u6fc0\u30fb\u30a2\u30ec\u30eb\u30ae\u30fc\u30ea\u30b9\u30af\u3092\u4e0b\u3052\u308b\u3001\u3068\u3044\u3046\u5b89\u5168\u6027\u8aac\u660e\u306e\u6839\u62e0\u3068\u3057\u3066\u8ee2\u7528\u3057\u3084\u3059\u3044\u3002
\r\n\r\n<\/pre>\n
 <\/p>\n
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