{"id":65765,"date":"2026-02-03T14:20:19","date_gmt":"2026-02-03T05:20:19","guid":{"rendered":"https:\/\/www.nahls.co.jp\/eijingukea\/?p=65765"},"modified":"2026-02-03T14:57:17","modified_gmt":"2026-02-03T05:57:17","slug":"kanon_neo","status":"publish","type":"post","link":"https:\/\/www.nahls.co.jp\/eijingukea\/evidences\/hiroba\/kanon_neo\/","title":{"rendered":"\u30ca\u30fc\u30eb\u30b9 \u30cd\u30aa\u3000(\u7f8e\u5bb9\u6db2)\u3067STEP2\u3078 by\u304b\u306e\u3093\u304b\u306e\u3093\u30de\u30de\u308a\u3093"},"content":{"rendered":"
\n

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\"\u30ca\u30fc\u30eb\u30b9\u30cd\u30aa\"<\/a><\/p>\n

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\u3010\u53c2\u8003\u3011
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 <\/p>\n

\uff1c\u53c2\u7167\u8ad6\u6587\uff1e<\/h2>\n

\u30101\u3011Kafi R, Kwak HSR, Schumacher WE, et al. Improvement of naturally aged skin with vitamin A (retinol). Arch Dermatol. 2007;143(5):606\u2013612.<\/a><\/cite>
\nPMID: 17515510\uff5cDOI: 10.1001\/archderm.143.5.606
\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u5916\u7528\u30ec\u30c1\u30ce\u30fc\u30eb\u304c\u81ea\u7136\u8001\u5316\u76ae\u819a\u306e\u5c0f\u3058\u308f\u3092\u6539\u5584\u3057\u3001\u771f\u76ae\u30b3\u30e9\u30fc\u30b2\u30f3\u3084\u4fdd\u6c34\u6027\u306b\u95a2\u308f\u308b\u6210\u5206\u306e\u5897\u52a0\u304c\u793a\u3055\u308c\u305f\u81e8\u5e8a\u7814\u7a76\u3002\u30ca\u30fc\u30eb\u30b9 \u30cd\u30aa\u3092\u300cSTEP2\u306e\u7f8e\u5bb9\u6db2\u300d\u3068\u3057\u3066\u53d6\u308a\u5165\u308c\u3001\u30cf\u30ea\u611f\u30fb\u3064\u3084\u611f\u3092\u5e95\u4e0a\u3052\u3059\u308b\u6587\u8108\u3067\u3001\u30d3\u30bf\u30df\u30f3A\u7cfb\u30b1\u30a2\u306e\u79d1\u5b66\u7684\u6839\u62e0\u3002<\/p>\n

\u30102\u3011Robinson LR, Fitzgerald NC, Doughty DG, et al. Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin. Int J Cosmet Sci. 2005;27(3):155\u2013160.<\/a><\/cite>
\nPMID: 18492182\uff5cDOI: 10.1111\/j.1467-2494.2005.00261.x
\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u30d1\u30eb\u30df\u30c8\u30a4\u30eb\u30da\u30f3\u30bf\u30da\u30d7\u30c1\u30c9\uff08pal-KTTKS\uff09\u914d\u5408\u5916\u7528\u5264\u304c\u3001\u5149\u8001\u5316\u306b\u3088\u308b\u3057\u308f\u30fb\u5c0f\u3058\u308f\u3092\u6709\u610f\u306b\u6539\u5584\u3057\u305f\u81e8\u5e8a\u7814\u7a76\u3002\u30ca\u30fc\u30eb\u30b9 \u30cd\u30aa\u306e\u3088\u3046\u306a\u7f8e\u5bb9\u6db2\u3067\u30da\u30d7\u30c1\u30c9\u7cfb\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u91cd\u306d\u3001\u5f3e\u529b\u30fb\u30cf\u30ea\u5370\u8c61\u3092\u72d9\u3046\u8aac\u660e\u306e\u88dc\u52a9\u30a8\u30d3\u30c7\u30f3\u30b9\u3002<\/p>\n

\u30103\u3011Humbert PG, Haftek M, Creidi P, et al. Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo. Exp Dermatol. 2003;12(3):237\u2013244.<\/a><\/cite>
\nPMID: 12823436\uff5cDOI: 10.1034\/j.1600-0625.2003.00008.x
\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u5916\u7528\u30d3\u30bf\u30df\u30f3C\u304c\u5149\u8001\u5316\u808c\u306e\u808c\u8868\u9762\u306e\u51f9\u51f8\u3084\u6df1\u3044\u6e9d\u306e\u6307\u6a19\u3092\u6539\u5584\u3057\u3001\u81e8\u5e8a\u7684\u306b\u3082\u808c\u8cea\u5411\u4e0a\u304c\u793a\u3055\u308c\u305f\u7814\u7a76\u3002\u30ca\u30fc\u30eb\u30b9 \u30cd\u30aa\u3092STEP2\u306b\u8db3\u3057\u3066\u300c\u304f\u3059\u307f\u611f\u3092\u6291\u3048\u3001\u3064\u3084\u30fb\u900f\u660e\u611f\u3092\u80b2\u3066\u308b\u300d\u65b9\u5411\u6027\u3092\u8aac\u660e\u3059\u308b\u969b\u306e\u4ee3\u8868\u7684\u6839\u62e0\u3002<\/p>\n

\u30104\u3011Bissett DL, Oblong JE, Berge CA. Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatol Surg. 2005;31(7 Pt 2):860\u2013865.<\/a><\/cite>
\nPMID: 16029679\uff5cDOI: 10.1111\/j.1524-4725.2005.31732
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\u30105\u3011Tanno O, Ota Y, Kitamura N, Katsube T, Inoue S. Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier. Br J Dermatol. 2000;143(3):524\u2013531.<\/a><\/cite>
\nPMID: 10971324\uff5cDOI: 10.1111\/j.1365-2133.2000.03705.x
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\u30106\u3011Sugahara Y, Komorisono M, Kuwajima M, Yoshikawa S, Yoshida S, Maeda K. Anti-skin-aging effects of human ceramides via collagen and fibrillin expression in dermal fibroblasts. Biosci Biotechnol Biochem. 2022;86(9):1240\u20131246.<\/a><\/cite>
\nPMID: 35776962\uff5cDOI: 10.1093\/bbb\/zbac107
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\u30107\u3011Sano M, Shang Y, Nakane A, Saito T. Salmon nasal cartilage proteoglycan enhances growth of normal human dermal fibroblast through Erk1\/2 phosphorylation. Biosci Biotechnol Biochem. 2017;81(7):1379\u20131385.<\/a><\/cite>
\nPMID: 28463592\uff5cDOI: 10.1080\/09168451.2017.1318695
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\u30108\u3011Ruiz Mart\u00ednez MA, Peralta Galisteo S, Cast\u00e1n H, Morales Hern\u00e1ndez ME. Role of proteoglycans on skin ageing: a review. Int J Cosmet Sci. 2020;42(6):529\u2013535.<\/a><\/cite>
\nPMID: 32895982\uff5cDOI: 10.1111\/ics.12660
\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u304c\u76ae\u819a\u306e\u4fdd\u6c34\u30fb\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30af\u30b9\u7dad\u6301\u306a\u3069\u306b\u95a2\u308f\u308a\u3001\u30a8\u30a4\u30b8\u30f3\u30b0\u30b5\u30a4\u30f3\uff08\u4e7e\u71e5\u30fb\u3057\u308f\uff09\u3068\u95a2\u4fc2\u3059\u308b\u53ef\u80fd\u6027\u3092\u6574\u7406\u3057\u305f\u30ec\u30d3\u30e5\u30fc\u3002\u30ca\u30fc\u30eb\u30b9 \u30cd\u30aa\u3067\u201c\u4fdd\u6e7f\u3060\u3051\u3067\u306a\u304f\u30cf\u30ea\u611f\u3082\u72d9\u3046STEP2\u201d\u3068\u3044\u3046\u8aac\u660e\u306e\u88cf\u4ed8\u3002<\/p>\n

 <\/p>\n

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