{"id":66140,"date":"2026-02-03T14:13:10","date_gmt":"2026-02-03T05:13:10","guid":{"rendered":"https:\/\/www.nahls.co.jp\/eijingukea\/?p=66140"},"modified":"2026-02-03T14:50:40","modified_gmt":"2026-02-03T05:50:40","slug":"kie_nahls2","status":"publish","type":"post","link":"https:\/\/www.nahls.co.jp\/eijingukea\/evidences\/hiroba\/kie_nahls2\/","title":{"rendered":"\u672c\u683c\u7684\u306a\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u3092\u304a\u8003\u3048\u306e\u65b9\u5fc5\u898b\uff01\u30ca\u30fc\u30eb\u30b9\u5316\u7ca7\u54c1\u4f7f\u7528\u30ec\u30dd\u30fc\u30c8\u300e\u30ca\u30fc\u30eb\u30b9\u300fVOl.2 by KIE"},"content":{"rendered":"
\n

\u300e\u30ca\u30fc\u30eb\u30b9\u300fVOL.1\u3067\u306f\u3001\u304a\u808c\u306e\u66f2\u304c\u308a\u89d2\u3092\u304b\u306a\u30fc\u30fc\u30fc\u308a\u524d\u304b\u3089\u611f\u3058\u3066\u3044\u308b\u79c1\u304c\u3001<\/p>\n

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\u52b9\u679c\u3092\u3088\u308a\u5b9f\u611f\u3059\u308b\u305f\u3081\u306b\u30e9\u30a4\u30f3\u3067\u4f7f\u7528<\/h2>\n

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1\uff09\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2<\/h3>\n

\"\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\"<\/a><\/p>\n

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\n\u305f\u308a\u306a\u3044\u306a\u3068\u601d\u3063\u305f\u3089\u30012\u56de\u304f\u3089\u3044\u306b\u5206\u3051\u3066\u306a\u3058\u307e\u305b\u308b\u3068\u3044\u3044\u304b\u3082\u3002<\/p>\n

\"\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\"<\/a><\/p>\n

2\uff09\u30ca\u30fc\u30eb\u30b9 \u30cd\u30aa<\/h3>\n

\"\u30ca\u30fc\u30eb\u30b9\u30cd\u30aa\"<\/a><\/p>\n

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\n\u7279\u306b\u6c17\u306b\u306a\u308b\u3001\u76ee\u5143<\/a>\u3084\u307b\u3046\u308c\u3044\u7dda<\/a>\u306b\u306f\u91cd\u306d\u3065\u3051\u304c\u30aa\u30b9\u30b9\u30e1\u3067\u3059\u3002<\/p>\n

\"\u30ca\u30fc\u30eb\u30b9\u30cd\u30aa\"<\/a><\/p>\n

1\u30d7\u30c3\u30b7\u30e5\u76ee\u306f\u3001\u9854\u5168\u4f53\u306b\u3002
\n2\u30d7\u30c3\u30b7\u30e5\u76ee\u306f\u3001\u76ee\u5143\u3084\u307b\u3046\u308c\u3044\u7dda\u306b\u30af\u30eb\u30af\u30eb\u3068\u30de\u30c3\u30b5\u30fc\u30b8\u3002<\/p>\n

\"\u30ca\u30fc\u30eb\u30b9\u30cd\u30aa\"<\/a><\/p>\n

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\u300c\u30cd\u30aa\u30c0\u30fc\u30df\u30eb\u300d\u300c\u91d1\u30b3\u30ed\u30a4\u30c9\u300d\u300c\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\u300d\u306f\uff13\u3064\u306e\u4e2d\u3067\u201d\u30ca\u30fc\u30eb\u30b9 \u30cd\u30aa\u201d\u3060\u3051\u3002<\/p>\n

3\uff09\u30ca\u30fc\u30eb\u30b9 \u30e6\u30cb\u30d0<\/h3>\n

\"\u30ca\u30fc\u30eb\u30b9\u30e6\u30cb\u30d0\"<\/a><\/p>\n

\u30d2\u30c8\u578b\u30bb\u30e9\u30df\u30c9\u30fb\u30b7\u30a2\u30d0\u30bf\u30fc\u30fb\u30b9\u30af\u30ef\u30e9\u30f3\u914d\u5408\u3067\u3001\u66f4\u306b\u4e0a\u304b\u3089\u30d4\u30bf\u30c3\u3068\u6f64\u3044\u3092\u30b5\u30dd\u30fc\u30c8\u3057\u307e\u3059\u3002<\/p>\n

\u4f7f\u3063\u305f\u611f\u60f3<\/h2>\n

\"\u30ca\u30fc\u30eb\u30b9\u5316\u7ca7\u54c1\"<\/a><\/p>\n

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\n\u7279\u306b\u53f3\u76ee\u306e\u4e0b\u304c\u3059\u3054\u304f\u6c17\u306b\u306a\u3063\u3066\u3044\u305f\u306e\u3067\u3059\u304c\u3001\u5de6\u76ee\u3068\u306e\u5dee\u304c\u306a\u304f\u306a\u3063\u3066\u6765\u307e\u3057\u305f\u3002<\/p>\n

\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u3092\u8003\u3048\u3066\u3044\u308b\u65b9\u306b\u306f\u304a\u3059\u3059\u3081\u3067\u3059\u3002<\/p>\n

https:\/\/www.nahls.co.jp\/<\/a><\/p>\n

\u30ca\u30fc\u30eb\u30b9\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u30a2\u30ab\u30c7\u30df\u30fc\u7de8\u96c6\u90e8\u30b3\u30e1\u30f3\u30c8<\/h2>\n

KIE\u3055\u3093\u3001\u30ca\u30fc\u30eb\u30b9\u88fd\u54c1\u306e\u30e9\u30a4\u30f3\u4f7f\u3044\u306b\u3064\u3044\u3066\u306e\u611f\u60f3\u7b2c2\u5f3e\u306e\u8a18\u4e8b\u3092\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3057\u305f\u3002<\/p>\n

\u7d04\uff11\u304b\u6708\u534a\u3054\u4f7f\u7528\u3044\u305f\u3060\u3044\u3066\u4e00\u756a\u5b9f\u611f\u3055\u308c\u305f\u306e\u304c\u300c\u304a\u808c\u306e\u4e7e\u71e5\u304c\u8efd\u6e1b\u3057\u305f\u3053\u3068\u300d\u3068\u306e\u3053\u3068\u3067\u3001\u672c\u5f53\u306b\u5b09\u3057\u3044\u3067\u3059\u3002
\nKIE\u3055\u3093\u306e\u304a\u808c\u306e\u6c34\u5206\u30d0\u30e9\u30f3\u30b9\u304c\u6574\u3063\u3066\u6765\u3089\u308c\u305f\u8a3c\u62e0\u3067\u3059\u3082\u3093\u306d\u3002<\/p>\n

\u3055\u3089\u306b\u3001\u76ee\u306e\u4e0b\u306e\u305f\u308b\u307f\u3082\u6c17\u306b\u306a\u3089\u306a\u304f\u306a\u3063\u3066\u5de6\u53f3\u5dee\u304c\u306a\u304f\u306a\u3063\u3066\u304d\u305f\u3068\u306e\u3053\u3068\u3002
\n\u305f\u308b\u307f\u304c\u6c17\u306b\u306a\u3089\u306a\u304f\u306a\u3063\u305f\u3068\u3044\u3046\u306e\u306f\u3001\u30ca\u30fc\u30eb\u30b9 \u30cd\u30aa\u3092\u304a\u4f7f\u3044\u306e\u65b9\u304b\u3089\u3088\u304f\u805e\u304f\u304a\u58f0\u3067\u3059\u3002<\/p>\n

KIE\u3055\u3093\u304c\u30ca\u30fc\u30eb\u30b9\u88fd\u54c1\u3092\u4f7f\u3044\u59cb\u3081\u3089\u308c\u305f\u6642\u306b\u3001\u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\u306b\u95a2\u3059\u308b\u8a73\u3057\u304f\u3054\u7d39\u4ecb\u3044\u305f\u3060\u3044\u305f\u300c\u753b\u671f\u7684\u306a\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u5316\u7ca7\u54c1\u6210\u5206\u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\u914d\u5408\u5316\u7ca7\u54c1\u300e\u30ca\u30fc\u30eb\u30b9\u300fVOl.1 by KIE<\/a>\u300d\u306e\u8a18\u4e8b\u3082\u3042\u308f\u305b\u3066\u304a\u8aad\u307f\u3044\u305f\u3060\u304f\u3068\u3001\u304d\u3063\u3068\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u30a2\u30ab\u30c7\u30df\u30fc\u306e\u8aad\u8005\u306e\u7686\u69d8\u306b\u3082\u5f79\u7acb\u3064\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n

\u79c1\u305f\u3061\u30ca\u30fc\u30eb\u30b9\u306f\u3001\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u5316\u7ca7\u54c1\u3092\u901a\u3057\u3066\u3001\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u4e16\u4ee3\u306e\u5973\u6027\u3060\u3051\u3067\u306a\u304f\u30d7\u30ec\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u4e16\u4ee3\u306e\u5973\u6027\u307f\u306a\u3055\u307e\u306e\u7f8e\u808c\u3065\u304f\u308a\u3092\u5fdc\u63f4\u3057\u305f\u3044\u3068\u9858\u3063\u3066\u304a\u308a\u307e\u3059\u3002<\/p>\n

\uff0a\u30ca\u30fc\u30eb\u30b9\u306e\u30d6\u30e9\u30f3\u30c9\u30b3\u30f3\u30bb\u30d7\u30c8<\/a><\/p>\n

 <\/p>\n

\uff1c\u53c2\u7167\u8ad6\u6587\uff1e<\/h2>\n

\u30101\u3011\u6e6f\u6d45\uff08\u5c0f\u5cf6\uff09\u660e\u5b50, \u6797\u7db8\u5b50, \u97d3\u7acb\u53cb, \u6e21\u8fba\u6587\u592a, \u5e73\u7af9\u6f64. \u03b3-\u30b0\u30eb\u30bf\u30df\u30eb\u30c8\u30e9\u30f3\u30b9\u30da\u30d7\u30c1\u30c0\u30fc\u30bc\uff08GGT\uff09\u963b\u5bb3\u5264\u306b\u3088\u308b\u30b3\u30e9\u30fc\u30b2\u30f3\u304a\u3088\u3073\u30a8\u30e9\u30b9\u30c1\u30f3\u7523\u751f\u80fd\u306e\u4ea2\u9032\u52b9\u679c\u3068\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0. \u65e5\u672c\u9999\u7ca7\u54c1\u5b66\u4f1a\u8a8c. 2012;36(2):93\u2013100.<\/a><\/cite><\/p>\n

\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\u00ae\u306e\u57fa\u3068\u306a\u308bGGT\u963b\u5bb3\u306b\u3088\u308a\u3001\u30d2\u30c8\u76ae\u819a\u7dda\u7dad\u82bd\u7d30\u80de\u3067\u30b3\u30e9\u30fc\u30b2\u30f3\u30fb\u30a8\u30e9\u30b9\u30c1\u30f3\u7523\u751f\u304c\u9ad8\u307e\u308b\u53ef\u80fd\u6027\u3092\u793a\u3057\u305f\u57fa\u790e\u7814\u7a76\u3002\u8a18\u4e8b\u3067\u8a9e\u3089\u308c\u308b\u300c\u30e9\u30a4\u30f3\u4f7f\u3044\u3067\u30cf\u30ea\u30fb\u5f3e\u529b\u3092\u5e95\u4e0a\u3052\u3057\u305f\u3044\u300d\u300c\u76ee\u5143\u306e\u5370\u8c61\uff08\u305f\u308b\u307f\u611f\uff09\u3082\u30b1\u30a2\u3057\u305f\u3044\u300d\u3068\u3044\u3046\u6587\u8108\u306b\u3001\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u306e\u201c\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u8ef8\u6210\u5206\u201d\u306e\u79d1\u5b66\u7684\u80cc\u666f\u3068\u3057\u3066\u4f4d\u7f6e\u3065\u3051\u3089\u308c\u308b\u3002<\/p>\n

\u30102\u3011Bissett DL, Oblong JE, Berge CA. Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatol Surg. 2005;31(7 Pt 2):860\u2013865.<\/a>
\n<\/cite>PMID: 16029679\uff5cDOI: 10.1111\/j.1524-4725.2005.31732
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\u30103\u3011Tanno O, Ota Y, Kitamura N, Katsube T, Inoue S. Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier. Br J Dermatol. 2000;143(3):524\u2013531.<\/a><\/cite>
\nPMID: 10971324\uff5cDOI: 10.1111\/j.1365-2133.2000.03705.x
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\u30104\u3011Sugahara Y, Komorisono M, Kuwajima M, Yoshikawa S, Yoshida S, Maeda K. Anti-skin-aging effects of human ceramides via collagen and fibrillin expression in dermal fibroblasts. Biosci Biotechnol Biochem. 2022;86(9):1240\u20131246.<\/a>
\n<\/cite>PMID: 35776962\uff5cDOI: 10.1093\/bbb\/zbac107
\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u30d2\u30c8\u7531\u6765\u30bb\u30e9\u30df\u30c9\u6df7\u5408\u7269\u304c\u7dda\u7dad\u82bd\u7d30\u80de\u3067\u30b3\u30e9\u30fc\u30b2\u30f3\u3084\u30d5\u30a3\u30d6\u30ea\u30ea\u30f3\u95a2\u9023\u306b\u5f71\u97ff\u3057\u3046\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u5831\u544a\u3002\u8a18\u4e8b\u5185\u3067\u89e6\u308c\u3089\u308c\u3066\u3044\u308b\u300c\u30d2\u30c8\u578b\u30bb\u30e9\u30df\u30c9\u914d\u5408\u3067\u6f64\u3044\u3092\u30b5\u30dd\u30fc\u30c8\uff08\u30ca\u30fc\u30eb\u30b9 \u30e6\u30cb\u30d0\uff09\u300d\u3068\u3044\u3046\u201c\u4fdd\u6e7f\uff0b\u30cf\u30ea\u611f\u201d\u306e\u8aac\u660e\u306b\u88dc\u52a9\u30a8\u30d3\u30c7\u30f3\u30b9\u3002<\/p>\n

\u30105\u3011Lintner K, Gerstein F, Solish N. A serum containing vitamins C & E and a matrix-repair tripeptide reduces facial signs of aging as evidenced by Primos\u00ae analysis and frequently repeated auto-perception. J Cosmet Dermatol. 2020;19(12):3262\u20133269.<\/a>
\n<\/cite>PMID: 33103342\uff5cDOI: 10.1111\/jocd.13770
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\u30106\u3011Humbert PG, Haftek M, Creidi P, et al. Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo. Exp Dermatol. 2003;12(3):237\u2013244.<\/a>
\n<\/cite>PMID: 12823436\uff5cDOI: 10.1034\/j.1600-0625.2003.00008.x
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\u30107\u3011Robinson LR, Fitzgerald NC, Doughty DG, Dawes NC, Berge CA, Bissett DL. Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin. Int J Cosmet Sci. 2005;27(3):155\u2013160.<\/a>
\n<\/cite>PMID: 18492182\uff5cDOI: 10.1111\/j.1467-2494.2005.00261.x
\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u30da\u30d7\u30c1\u30c9\uff08palmitoyl pentapeptide\uff09\u306e\u5916\u7528\u3067\u5149\u8001\u5316\u306b\u4f34\u3046\u898b\u305f\u76ee\u6307\u6a19\u306e\u6539\u5584\u3092\u793a\u3057\u305f\u5831\u544a\u3002\u8a18\u4e8b\u306e\u300c\u76ee\u5143\u306e\u305f\u308b\u307f\u304c\u6c17\u306b\u306a\u308a\u306b\u304f\u304f\u306a\u3063\u305f\u300d\u300c\u307b\u3046\u308c\u3044\u7dda\u306b\u306f\u91cd\u306d\u3065\u3051\u300d\u306a\u3069\u3001\u201c\u30cf\u30ea\u611f\u30fb\u3057\u308f\u5370\u8c61\u30b1\u30a2\u201d\u306e\u88dc\u52a9\u6839\u62e0\u3002<\/p>\n

\u30108\u3011Rao A, Briskey D, Roche G, Tremblay A, Da Silva Pinto M, Tompkins TA. Trans-resveratrol reduces visible signs of skin ageing in healthy adult females over 40: an 8-week randomized placebo-controlled trial.<\/a>
\n<\/cite>PMID: 41488277\uff5cDOI: \uff08PubMed\u63b2\u8f09\u60c5\u5831\u306b\u57fa\u3065\u304f\uff09
\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>40\u6b73\u4ee5\u4e0a\u5973\u6027\u3092\u5bfe\u8c61\u306b\u3001\u30c8\u30e9\u30f3\u30b9\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\u306e\u7d4c\u53e3\u30fb\u5916\u7528\u4ecb\u5165\u3067\u3057\u308f\u30b9\u30b3\u30a2\u3084\u76ae\u8102\u91cf\u306a\u3069\u3092\u8a55\u4fa1\u3057\u305f\u4e8c\u91cd\u76f2\u691cRCT\u3002\u8a18\u4e8b\u3067\u89e6\u308c\u3089\u308c\u3066\u3044\u308b\u300c\u30ec\u30b9\u30d9\u30e9\u30c8\u30ed\u30fc\u30eb\uff08\u6297\u9178\u5316\uff09\u914d\u5408\u300d\u304b\u3089\u3001\u201c\u4e7e\u71e5\u3057\u304c\u3061\u306a\u4e16\u4ee3\u306e\u808c\u30b3\u30f3\u30c7\u30a3\u30b7\u30e7\u30f3\u3092\u5b88\u308b\u6297\u9178\u5316\u8a2d\u8a08\u201d\u3068\u3044\u3046\u8aac\u660e\u306e\u6839\u62e0\u3002<\/p>\n

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