{"id":66355,"date":"2026-01-22T20:05:47","date_gmt":"2026-01-22T11:05:47","guid":{"rendered":"https:\/\/www.nahls.co.jp\/eijingukea\/?p=66355"},"modified":"2026-01-22T21:40:56","modified_gmt":"2026-01-22T12:40:56","slug":"chiro_nahlspure","status":"publish","type":"post","link":"https:\/\/www.nahls.co.jp\/eijingukea\/evidences\/hiroba\/chiro_nahlspure\/","title":{"rendered":"\u5b63\u7bc0\u3084\u5e74\u9f62\u306b\u8ca0\u3051\u306a\u3044\u7f8e\u808c\u4f5c\u308a\u306b\u300c\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u300d\u3092\u30ea\u30d4\u30fc\u30c8\u4e2d\u3067\u3059\u266a by \u30c1\u30ed\u30b3\u30ca\u30ce"},"content":{"rendered":"
\u30a2\u30e9\u30d5\u30a9\u30fc\u7f8e\u5bb9\u30aa\u30bf\u30af\u306e\u30c1\u30ed\u30b3\u30ca\u30ce\u3067\u3059(^_-)-\u2606<\/span><\/p>\n \u6885\u96e8\u306e\u3058\u3068\u3058\u3068\u3068\u3057\u305f\u5acc\u3041\uff5e\u306a\u5b63\u7bc0\u3082\u3082\u3046\u5c11\u3057\u3001\u3067\u3082\u590f\u306b\u306a\u308c\u3070\u30ab\u30e9\u3063\u3068\u3057\u307e\u3059\u304c\u4eca\u5ea6\u306f\u6c57\u3067\u30d9\u30bf\u3064\u304f\u5b63\u7bc0\u3002<\/p>\n \u304a\u98a8\u5442\u4e0a\u308a\u306b\u6c17\u6301\u3061\u3088\u304f\u30b9\u30ad\u30f3\u30b1\u30a2\u3057\u305f\u3044\u3002\u3002\u3002<\/p>\n \u3068\u3044\u3046\u308f\u3051\u3067\u3001\u4eca\u56de\u306f\u6885\u96e8\u3067\u3082\u771f\u590f\u3067\u3082\u4f7f\u3044\u3084\u3059\u3044\uff01\u3068\u3044\u3046\u304b1\u5e74\u4e2d\u4f7f\u3044\u305f\u3044\u5316\u7ca7\u6c34\u3092\u53e3\u30b3\u30df\u3057\u307e\u3059\u306d\u3002<\/p>\n \u305d\u308c\u306f\u300c\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2+\u300d<\/span><\/p>\n 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\u30cd\u30aa\uff08\u7f8e\u5bb9\u6db2\uff09\u3001\u30ca\u30fc\u30eb\u30b9 \u30e6\u30cb\u30d0\uff08\u30af\u30ea\u30fc\u30e0\uff09\u306e\u30e9\u30a4\u30f3\u4f7f\u3044\u3067\u3059\u3002<\/p>\n \u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\u914d\u5408\u306e\u30b9\u30ad\u30f3\u30b1\u30a2\u30e9\u30a4\u30f3\u306a\u306e\u3067\u3001\u76f8\u4e57\u52b9\u679c<\/span>\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u304b\u3089\u306d\u266a<\/p>\n \u3068\u3044\u3046\u308f\u3051\u3067\u3001\u3053\u308c\u304b\u3089\u3082\u7f8e\u9b54\u5973\u306b\u61a7\u308c\u3064\u3064\u3001\u7f8e\u808c\u4f5c\u308a\u9811\u5f35\u308a\u307e\u3059(*’\u03c9’*)\u3000<\/span><\/p>\n \u5c0f\u3055\u3044\u30c1\u30d3\u3061\u3083\u3093\u304c\u3044\u307e\u3059\u304b\u3089\u306d\u3001\u82e5\u3044\u30de\u30de\u306b\u3082\u8ca0\u3051\u3089\u308c\u306a\u3044\u305e\uff5e\u3002\u3002\u3002\uff6b\uff6b\uff01<\/p>\n \u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\u306f\u3001\u958b\u767a\u5f53\u521d\u304b\u3089\u3001\u771f\u76ae\u306b\u3042\u308b\u30b3\u30e9\u30fc\u30b2\u30f3\u3001\u30a8\u30e9\u30b9\u30c1\u30f3\u3001\u30d2\u30fc\u30c8\u30b7\u30e7\u30c3\u30af\u30d7\u30ed\u30c6\u30a4\u30f3(HSP)47\u3092\u5897\u3084\u3059\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n \u5b9f\u306f\u3001\u6700\u8fd1\u3001\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u3084\u30d2\u30fc\u30c8\u30b7\u30e7\u30c3\u30af\u30d7\u30ed\u30c6\u30a4\u30f3(HSP)70\u3092\u5897\u3084\u3059\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n \u3068\u3044\u3046\u3053\u3068\u3067HSP70\u304c\u7f8e\u808c\u306b\u3069\u3093\u306a\u826f\u3044\u52b9\u679c\u304c\u3042\u308b\u304b\u306b\u3064\u3044\u3066\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n HSP47\u306f\u3001\u771f\u76ae\u3067\u30b3\u30e9\u30fc\u30b2\u30f3\u3092\u30ad\u30ec\u30a4\u306a\u30ab\u30bf\u30c1\u306b\u3059\u308b\u3053\u3068\u3067\u3001\u808c\u306e\u30cf\u30ea\u3092\u30b5\u30dd\u30fc\u30c8\u3057\u307e\u3059\u3002<\/p>\n \u4e00\u65b9\u3001HSP70\u306f\u3001\u8868\u76ae\u306b\u3042\u3063\u3066\u305d\u3053\u3067\u3001\u304a\u808c\u306e\u7d30\u80de\u3092\u5b88\u308b\u306f\u305f\u3089\u304d\u304c\u5f37\u3044\u306e\u3067\u3059\uff01<\/p>\n 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\u305f\u3068\u3048\u3070\u3001HSP70\u306f\u7d2b\u5916\u7dda\u304c\u808c\u306b\u5f53\u305f\u308b\u3068\u305d\u308c\u306b\u53cd\u5fdc\u3057\u3001\u30e1\u30e9\u30cb\u30f3\u306e\u904e\u5270\u306a\u751f\u6210\u3092\u6291\u3048\u307e\u3059\u3002\u3060\u304b\u3089\u3001\u30b7\u30df\u306e\u4e88\u9632\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/p>\n \u307e\u305f\u3001HSP70\u306b\u306f\u708e\u75c7\u3092\u6291\u5236\u3059\u308b\u4f5c\u7528\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n \u3060\u304b\u3089\u3001\u7d2b\u5916\u7dda\u306b\u3088\u308b\u65e5\u713c\u3051\uff08\u30b5\u30f3\u30d0\u30fc\u30f3\u3068\u30b5\u30f3\u30bf\u30f3\uff09\u3082\u4e88\u9632\u3082\u671f\u5f85\u3067\u304d\u308b\u306e\u3067\u3059\u3002<\/p>\n \u3055\u3089\u306b\u3001\u305d\u306e\u306f\u305f\u3089\u304d\u3067\u7d2b\u5916\u7dda\u306b\u3088\u308b\u808c\u8001\u5316\u3001\u3064\u307e\u308a\u3001\u5149\u8001\u5316\u306b\u3088\u308b\u3001\u9854\u306e\u305f\u308b\u307f\u3084\u30b7\u30ef\u3001\u307b\u3046\u308c\u3044\u7dda\u3092\u4e88\u9632\u3057\u3066\u304f\u308c\u308b\u306e\u3067\u3059\u3002<\/p>\n \u305d\u3093\u306aHSP70\u3092\u5897\u3084\u3059\u30dd\u30a4\u30f3\u30c8\u306f\u3001\u6b21\u306e5\u3064\u3067\u3059\u3002<\/p>\n \u9069\u5ea6\u306a\u904b\u52d5\u3067\u4ee3\u8b1d\u3092\u30a2\u30c3\u30d7\u3059\u308b\uff08\u30b8\u30e7\u30ae\u30f3\u30b0\u3084\u52a0\u5727\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\uff09<\/p>\n<\/li>\n<\/ul>\n \uff1c\u3054\u53c2\u8003\uff1e<\/p>\n \uff0a\u30b7\u30df\u3092\u4e88\u9632\u3059\u308bHSP\uff08\u30d2\u30fc\u30c8\u30b7\u30e7\u30c3\u30af\u30d7\u30ed\u30c6\u30a4\u30f3\uff09\u306e\u52b9\u679c\u3068\u306f?<\/a><\/p>\n \uff0aHSP(\u30d2\u30fc\u30c8\u30b7\u30e7\u30c3\u30af\u30d7\u30ed\u30c6\u30a4\u30f3)\u3067\u30b7\u30ef\u3084\u307b\u3046\u308c\u3044\u7dda\u304c\u4e88\u9632\u3067\u304d\u308b\uff01<\/a><\/p>\n \uff0aHSP\uff08\u30d2\u30fc\u30c8\u30b7\u30e7\u30c3\u30af\u30d7\u30ed\u30c6\u30a4\u30f3\uff09\u3092\u5897\u3084\u30597\u3064\u306e\u65b9\u6cd5\u3067\u7f8e\u808c\u3078\uff01<\/a><\/p>\n \u30c1\u30ed\u30b3\u30ca\u30ce\u3055\u3093\u3001\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u306e\u3054\u4f7f\u7528\u5b9f\u611f\u306b\u3064\u3044\u3066\u306e\u8a18\u4e8b\u306e\u3054\u57f7\u7b46\u3092\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3057\u305f\u3002<\/p>\n \u307e\u305f\u3001\u7279\u5fb4\u3084\u914d\u5408\u6210\u5206\u306e\u8a73\u3057\u3044\u8aac\u660e\u3001\u30ca\u30fc\u30eb\u30b9 \u30cd\u30aa\u3084\u30ca\u30fc\u30eb\u30b9 \u30e6\u30cb\u30d0\u306e\u3054\u7d39\u4ecb\u3082\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3057\u305f\u3002<\/p>\n \u30ca\u30fc\u30eb\u30b9\u306e\u5316\u7ca7\u54c1\u306e\u30e1\u30a4\u30f3\u3068\u306a\u308b\u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\u306f\u3044\u307e\u3060\u306b\u8272\u3093\u306a\u7814\u7a76\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n \u4eca\u56de\u3001\u30ca\u30fc\u30eb\u30b9\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u30a2\u30ab\u30c7\u30df\u30fc\u304b\u3089\u306f\u30d2\u30fc\u30c8\u30b7\u30e7\u30c3\u30af\u30d7\u30ed\u30c6\u30a4\u30f3\u3068\u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\u306b\u3064\u3044\u3066\u3054\u7d39\u4ecb\u3057\u307e\u3057\u305f\u304c\u3001\u4ed6\u306b\u3082\u307e\u3060\u7814\u7a76\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n \u3053\u306e\u8a18\u4e8b\u300c\u5b63\u7bc0\u3084\u5e74\u9f62\u306b\u8ca0\u3051\u306a\u3044\u7f8e\u808c\u4f5c\u308a\u306b\u300c\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u300d\u3092\u30ea\u30d4\u30fc\u30c8\u4e2d\u3067\u3059\u266a by \u30c1\u30ed\u30b3\u30ca\u30ce\u300d\u304c\u3001\u30ca\u30fc\u30eb\u30b9\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u30a2\u30ab\u30c7\u30df\u30fc\u306e\u8aad\u8005\u306e\u307f\u306a\u3055\u307e\u306e\u304a\u5f79\u306b\u7acb\u3064\u3053\u3068\u3092\u9858\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n \uff1c\u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\u306e\u6700\u65b0\u7814\u7a76\uff1e <\/p>\n <\/p>\n \uff08\u7de8\u96c6\u30fb\u6821\u6b63\uff1a\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u30a2\u30ab\u30c7\u30df\u30fc\u7de8\u96c6\u90e8\u3000\u3084\u3059\u3060\u3068\u3082\u3088<\/a>\uff09 \u5f53\u793e\u30b9\u30bf\u30c3\u30d5\u306e\u672c\u696d\u306f\u3001\u533b\u5b66\u30fb\u85ac\u5b66\u95a2\u9023\u306e\u4e8b\u696d\u306e\u305f\u3081\u3001\u65e5\u3005\u3001\u533b\u5b66\u8ad6\u6587\u3084\u533b\u5b66\u4f1a\u306e\u767a\u8868\u306a\u3069\u306e\u6700\u65b0\u60c5\u5831\u306b\u89e6\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n \u305d\u3093\u306a\u4e2d\u3067\u3001\u300c\u3053\u308c\u306f\uff01\u300d\u3068\u3044\u3046\u3001\u307f\u306a\u3055\u307e\u306e\u5065\u5eb7\u3065\u304f\u308a\u306e\u3054\u53c2\u8003\u306b\u306a\u308b\u3088\u3046\u306a\u60c5\u5831\u3054\u7d39\u4ecb\u3057\u305f\u308a\u3001
<\/a><\/p>\n1\uff0e\u304a\u808c\u306b\u305f\u3063\u3077\u308a\u3042\u3052\u305f\u3044\u300c\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2+\u300d<\/h2>\n
\n
2\uff0e\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u3092\u4f7f\u3063\u3066\u307f\u305f\u53e3\u30b3\u30df<\/h2>\n
<\/a><\/p>\n
<\/a><\/p>\n3\uff0e\u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\u304c\u5897\u3084\u3059\u30d2\u30fc\u30c8\u30b7\u30e7\u30c3\u30af\u30d7\u30ed\u30c6\u30a4\u30f3\u306e\u52b9\u679c\u3063\u3066\uff1f\uff08\u30ca\u30fc\u30eb\u30b9\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u30a2\u30ab\u30c7\u30df\u30fc\u7de8\u96c6\u90e8\uff09<\/h2>\n
\n
4\uff0e\u30ca\u30fc\u30eb\u30b9\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u30a2\u30ab\u30c7\u30df\u30fc\u7de8\u96c6\u90e8\u30b3\u30e1\u30f3\u30c8<\/h2>\n
\n\uff0a\u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\u306e\u53e3\u306e\u7c98\u819c\u306e\u50b7\u304c\u65e9\u304f\u6cbb\u308b\u52b9\u679c\uff01\u533b\u5b66\u8ad6\u6587\u3067\u5831\u544a<\/a><\/p>\n\uff1c\u53c2\u7167\u8ad6\u6587\uff1e<\/h2>\n
\r\n\u30101\u3011Bissett DL, Oblong JE, Berge CA. Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatologic Surgery. 2005 31(7 Pt 2):860\u2013865.<\/a><\/cite>
\r\n\r\n\r\nPMID: 16029679\uff5cDOI: 10.1111\/j.1524-4725.2005.31726
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u5916\u7528\u306b\u3088\u308a\u5c0f\u3058\u308f\u30fb\u8272\u30e0\u30e9\u30fb\u30d0\u30ea\u30a2\u6a5f\u80fd\u306e\u6539\u5584\u304c\u793a\u3055\u308c\u305f\u7814\u7a76\u3067\u3042\u308b\u3002\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u306b\u542b\u307e\u308c\u308b\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u304c\u3001\u808c\u30d0\u30ea\u30a2\u3068\u6f64\u3044\u3092\u652f\u3048\u3001\u5b63\u7bc0\u3084\u5e74\u9f62\u306b\u3088\u308b\u4e7e\u71e5\u3092\u9632\u3050\u6839\u62e0\u3002
\r\n\r\n\u30102\u3011Pullar JM, Carr AC, Vissers MCM. The Roles of Vitamin C in Skin Health. Nutrients. 2017 9(8):866.<\/a><\/cite>
\r\n\r\nPMID: 28805671\uff5cDOI: 10.3390\/nu9080866
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u30d3\u30bf\u30df\u30f3 C \u306f\u30b3\u30e9\u30fc\u30b2\u30f3\u5408\u6210\u4fc3\u9032\u30fb\u6297\u9178\u5316\u4f5c\u7528\u30fb\u708e\u75c7\u6291\u5236\u3092\u542b\u3080\u808c\u306e\u5065\u5eb7\u7dad\u6301\u306b\u591a\u9762\u7684\u306b\u5bc4\u4e0e\u3059\u308b\u3002\u672c\u8ad6\u6587\u306f\u3001\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u306e\u30d3\u30bf\u30df\u30f3 C \u8a98\u5c0e\u4f53\u304c\u771f\u76ae\u69cb\u9020\u3084\u808c\u306e\u660e\u308b\u3055\u306e\u7dad\u6301\u3092\u52a9\u3051\u3001\u5e74\u9f62\u306b\u3088\u308b\u808c\u60a9\u307f\u306e\u6539\u5584\u3092\u652f\u3048\u308b\u79d1\u5b66\u7684\u80cc\u666f\u3002
\r\n\r\n\u30103\u3011Rawlings AV, Harding CR. Moisturization and skin barrier function. Dermatologic Therapy. 2004 17(Suppl 1):43\u201348.<\/a><\/cite>
\r\n\r\nPMID: 14728698\uff5cDOI: 10.1111\/j.1396-0296.2004.04s1005.x
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u89d2\u8cea\u5c64\u306e\u6c34\u5206\u4fdd\u6301\u3068\u30d0\u30ea\u30a2\u6a5f\u80fd\u306e\u95a2\u9023\u3092\u4f53\u7cfb\u7684\u306b\u793a\u3057\u305f\u30ec\u30d3\u30e5\u30fc\u3067\u3042\u308b\u3002\u9ad8\u4fdd\u6e7f\u8a2d\u8a08\u306e\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u306f\u3001\u4e7e\u71e5\u3057\u3084\u3059\u3044\u5b63\u7bc0\u3084\u5e74\u9f62\u74b0\u5883\u306b\u304a\u3051\u308b\u89d2\u8cea\u30d0\u30ea\u30a2\u306e\u7dad\u6301\u3092\u652f\u3048\u308b\u7406\u8ad6\u7684\u6839\u62e0\u3002
\r\n\r\n\u30104\u3011Draelos ZD. The science behind skin care: Moisturizers. Journal of Cosmetic Dermatology. 2018 17(2):138\u2013144.<\/a><\/cite>
\r\n\r\nPMID: 29319217\uff5cDOI: 10.1111\/jocd.12490
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u4fdd\u6e7f\u5264\u306e\u4f5c\u7528\u6a5f\u5e8f\u3092\u6574\u7406\u3057\u305f\u7dcf\u8aac\u3067\u3042\u308a\u3001\u30d2\u30e5\u30fc\u30e1\u30af\u30bf\u30f3\u30c8\u3084\u30a8\u30e2\u30ea\u30a8\u30f3\u30c8\u306e\u5f79\u5272\u3092\u89e3\u8aac\u3057\u3066\u3044\u308b\u3002\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u306e\u4f4e\u523a\u6fc0\u30fb\u9ad8\u4fdd\u6e7f\u8a2d\u8a08\u306f\u3001\u5b63\u7bc0\u5909\u52d5\u3084\u5e74\u9f62\u306b\u4f34\u3046\u808c\u4e7e\u71e5\u306b\u5bfe\u5fdc\u3059\u308b\u7d99\u7d9a\u30b1\u30a2\u3068\u3057\u3066\u5408\u7406\u7684\u3067\u3042\u308b\u3002
\r\n\r\n\u30105\u3011Verdier-S\u00e9vrain S, Bont\u00e9 F. Skin hydration: a review on its molecular mechanisms. Journal of Cosmetic Dermatology. 2007 6(2):75\u201382.<\/a><\/cite>
\r\n\r\nPMID: 17524122\uff5cDOI: 10.1111\/j.1473-2165.2007.00300.x
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u76ae\u819a\u306e\u6f64\u3044\u4fdd\u6301\u306f\u5929\u7136\u4fdd\u6e7f\u56e0\u5b50\uff08NMF\uff09\u3068\u7d30\u80de\u9593\u8102\u8cea\u306e\u9023\u52d5\u306b\u4f9d\u5b58\u3059\u308b\u3053\u3068\u3092\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u8aac\u660e\u3057\u3066\u3044\u308b\u3002\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u306b\u542b\u307e\u308c\u308b\u6210\u5206\u304cNMF\u95a2\u9023\u6a5f\u69cb\u3092\u88dc\u3044\u3001\u5b63\u7bc0\u30fb\u5e74\u9f62\u306b\u3088\u308b\u6f64\u3044\u4e0d\u8db3\u3092\u4e88\u9632\u3059\u308b\u652f\u6301\u6587\u732e\u3002
\r\n\r\n\u30106\u3011Elias PM, Steinhoff M. Skin barrier function. Current Allergy and Asthma Reports. 2008 8(4):299\u2013305.<\/a><\/cite>
\r\n\r\nPMID: 18606081\uff5cDOI: 10.1007\/s11882-008-0048-7
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u76ae\u819a\u30d0\u30ea\u30a2\u6a5f\u80fd\u3068\u708e\u75c7\u30fb\u30b9\u30c8\u30ec\u30b9\u53cd\u5fdc\u306e\u95a2\u4fc2\u3092\u7dcf\u8aac\u3057\u305f\u8ad6\u6587\u3067\u3042\u308b\u3002\u30d0\u30ea\u30a2\u6a5f\u80fd\u5f37\u5316\u306f\u5916\u7684\u523a\u6fc0\u306b\u5bfe\u3059\u308b\u8010\u6027\u3092\u9ad8\u3081\u308b\u3068\u3044\u3046\u89b3\u70b9\u304b\u3089\u3001\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u306e\u30d0\u30ea\u30a2\u30b5\u30dd\u30fc\u30c8\u51e6\u65b9\u304c\u5b63\u7bc0\u30fb\u5e74\u9f62\u5909\u5316\u306b\u5f37\u3044\u808c\u3065\u304f\u308a\u3092\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u80cc\u666f\u3002
\r\n\r\n\u30107\u3011Lod\u00e9n M. Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. American Journal of Clinical Dermatology. 2003 4(11):771\u2013788.<\/a><\/cite>
\r\n\r\nPMID: 14572299\uff5cDOI: 10.2165\/00128071-200304110-00005
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u4fdd\u6e7f\u5264\u306e\u4e7e\u71e5\u808c\u30fb\u30d0\u30ea\u30a2\u969c\u5bb3\u3078\u306e\u52b9\u679c\u3092\u6574\u7406\u3057\u305f\u7dcf\u8aac\u3067\u3042\u308b\u3002\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u306e\u7d99\u7d9a\u4f7f\u7528\u306b\u3088\u308a\u3001\u4e7e\u71e5\u3084\u5916\u7684\u523a\u6fc0\u306b\u8ca0\u3051\u306a\u3044\u808c\u30b3\u30f3\u30c7\u30a3\u30b7\u30e7\u30f3\u306e\u7dad\u6301\u304c\u671f\u5f85\u3067\u304d\u3001\u5b63\u7bc0\u5909\u5316\u306b\u8ca0\u3051\u306a\u3044\u7f8e\u808c\u3065\u304f\u308a\u3092\u652f\u3048\u308b\u6839\u62e0\u3068\u306a\u308b\u3002
\r\n\r\n\u30108\u3011Ham SY, Pyo MJ, Kang M, Kim Y-S, Lee DH, Chung JH, Lee S-T. HSP47 increases the expression of type I collagen in fibroblasts through IRE1\u03b1 activation, XBP1 splicing, and nuclear translocation of \u03b2-catenin. Cells. 2024 13(6):527.<\/a><\/cite>
\r\n\r\nPMID: 38534372\uff5cDOI: 10.3390\/cells13060527
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u672c\u7814\u7a76\u306f\u3001\u30d2\u30fc\u30c8\u30b7\u30e7\u30c3\u30af\u30d7\u30ed\u30c6\u30a4\u30f347\uff08HSP47\uff09\u304c\u7dda\u7dad\u82bd\u7d30\u80de\u306b\u304a\u3051\u308b\u2160\u578b\u30b3\u30e9\u30fc\u30b2\u30f3\u7523\u751f\u3092\u4fc3\u9032\u3059\u308b\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3082\u306e\u3067\u3042\u308b\u3002HSP47\u306f\u5c0f\u80de\u4f53\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\uff08IRE1\u03b1\u2013XBP1\u7d4c\u8def\uff09\u3092\u6d3b\u6027\u5316\u3057\u3001\u03b2-\u30ab\u30c6\u30cb\u30f3\u306e\u6838\u5185\u79fb\u884c\u3092\u4ecb\u3057\u3066\u30b3\u30e9\u30fc\u30b2\u30f3\u767a\u73fe\u3068\u5206\u6ccc\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u3053\u308c\u306f\u3001\u771f\u76ae\u30b3\u30e9\u30fc\u30b2\u30f3\u306e\u8cea\u3068\u91cf\u306e\u7dad\u6301\u304c\u3001\u5e74\u9f62\u3084\u5b63\u7bc0\u5909\u5316\u306b\u8ca0\u3051\u306a\u3044\u808c\u306e\u30cf\u30ea\u30fb\u5f3e\u529b\u306b\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3059\u308b\u3002\r\n\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u306b\u542b\u307e\u308c\u308b\u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\u306f\u3001\u7dda\u7dad\u82bd\u7d30\u80de\u6d3b\u6027\u3084\u30b3\u30e9\u30fc\u30b2\u30f3\u7523\u751f\u74b0\u5883\u3092\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u8a2d\u8a08\u3067\u3042\u308a\u3001HSP47\u3092\u4ecb\u3057\u305f\u30b3\u30e9\u30fc\u30b2\u30f3\u6210\u719f\u30fb\u5b89\u5b9a\u5316\u3068\u3044\u3046\u89b3\u70b9\u304b\u3089\u3082\u3001\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u306e\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u5316\u7ca7\u6c34\u3068\u3057\u3066\u306e\u8a2d\u8a08\u601d\u60f3\u3092\u6307\u793a\u3059\u308b\u3002
\r\n\r\n\u30109\u3011\u6e6f\u6d45\uff08\u5c0f\u5cf6\uff09\u660e\u5b50, \u6797\u7db8\u5b50, \u97d3\u7acb\u53cb, \u6e21\u8fba\u6587\u592a, \u5e73\u7af9\u6f64. \u03b3-\u30b0\u30eb\u30bf\u30df\u30eb\u30c8\u30e9\u30f3\u30b9\u30d7\u30c1\u30c0\u30fc\u30bc\uff08GGT\uff09\u963b\u5bb3\u5264\u306b\u3088\u308b\u30b3\u30e9\u30fc\u30b2\u30f3\u304a\u3088\u3073\u30a8\u30e9\u30b9\u30c1\u30f3\u7523\u751f\u80fd\u306e\u4ea2\u9032\u52b9\u679c\u3068\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0. \u65e5\u672c\u9999\u7ca7\u54c1\u5b66\u4f1a\u8a8c. 2012;36(2):93\u2013100.<\/a><\/cite>
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u672c\u7814\u7a76\u306f\u3001\u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\u00ae\u306e\u57fa\u3068\u306a\u308b\u03b3-\u30b0\u30eb\u30bf\u30df\u30eb\u30c8\u30e9\u30f3\u30b9\u30da\u30d7\u30c1\u30c0\u30fc\u30bc\uff08GGT\uff09\u963b\u5bb3\u5264\u304c\u3001\u30d2\u30c8\u76ae\u819a\u7dda\u7dad\u82bd\u7d30\u80de\u306b\u4f5c\u7528\u3057\u3066\u30b3\u30e9\u30fc\u30b2\u30f3\u304a\u3088\u3073\u30a8\u30e9\u30b9\u30c1\u30f3\u306e\u7523\u751f\u3092\u4fc3\u9032\u3059\u308b\u6a5f\u5e8f\u3092\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u89e3\u6790\u3057\u305f\u3082\u306e\u3067\u3042\u308b\u3002\u5b9f\u9a13\u3067\u306f\u3001\u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\u304c\u7dda\u7dad\u82bd\u7d30\u80de\u306e\u8ce6\u6d3b\u306b\u3064\u306a\u304c\u308a\u3001\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u52b9\u679c\uff08\u808c\u306e\u30cf\u30ea\uff09\u3092\u652f\u3048\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u305f\u3002\u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\u306e\u79d1\u5b66\u7684\u306a\u6839\u62e0\u3068\u3057\u3066\u5f15\u7528\u3067\u304d\u308b\u91cd\u8981\u306a\u5b66\u8853\u8ad6\u6587\u3002\r\n\r\n<\/pre>\n
\n\u533b\u5b66\u51fa\u7248\u793e\u3001\u533b\u5b66\u7cfb\u5e83\u544a\u4ee3\u7406\u5e97\u306b\u3066\u7de8\u96c6\u30fb\u30e9\u30a4\u30bf\u30fc\u3068\u3057\u3066\u3001\u533b\u5e2b\u5411\u3051\u3001\u60a3\u8005\u5411\u3051\u306e\u60c5\u5831\u63d0\u4f9b\u8cc7\u6750\u3084\u66f8\u7c4d\u7b49\u306e\u8a18\u4e8b\u306e\u7de8\u96c6\u30fb\u57f7\u7b46\u3084\u3001\u56fd\u5185\u30fb\u6d77\u5916\u533b\u5b66\u4f1a\u53d6\u6750\u30fb\u8a18\u4e8b\u57f7\u7b46\u3092\u884c\u3046\u3002<\/p>\n
\n\u305d\u306e\u6642\u671f\u306b\u5408\u3063\u305f\u30b9\u30ad\u30f3\u30b1\u30a2\u3084\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u306e\u304a\u5f79\u7acb\u3061\u60c5\u5831\u3092\u30e1\u30fc\u30eb\u3067\u30b3\u30f3\u30d1\u30af\u30c8\u306b\u304a\u5c4a\u3051\u3057\u3066\u3044\u307e\u3059\u3002
\n\u305c\u3072\u3054\u767b\u9332\u3092\u304a\u5f85\u3061\u3057\u3066\u304a\u308a\u307e\u3059\u3002<\/p>\n