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\u8fd1\u8d64\u5916\u7dda\u306f\u3001\u8d64\u5916\u7dda\u306e1\u3064\u3067\u7d2b\u5916\u7dda\u3084\u53ef\u8996\u5149\u7dda\u3088\u308a\u6ce2\u9577\u304c\u9577\u3044\u96fb\u78c1\u6ce2\u3067\u3059\u3002\u307e\u305f\u3001\u4eba\u306e\u76ee\u3067\u898b\u308b\u3053\u3068\u306f\u3067\u304d\u306a\u3044\u4e0d\u53ef\u8996\u5149\u7dda\u3067\u3059\u3002<\/p>\n \u8fd1\u8d64\u5916\u7dda\u306b\u306f\u3001\u771f\u76ae\u3084\u76ae\u819a\u306e\u5965\u3067\u3042\u308b\u76ae\u4e0b\u7d44\u7e54\u307e\u3067\u6d78\u900f\u3057\u3066\u708e\u75c7\u3092\u4fc3\u3059\u7269\u8cea\u3092\u5897\u3084\u3059\u306f\u305f\u3089\u304d\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n \u8fd1\u8d64\u5916\u7dda\u306f\u3001UVA\u3001\u306a\u304b\u3067\u3082\u6ce2\u9577\u306e\u9577\u3044\u30ed\u30f3\u30b0UVA\u306b\u8fd1\u3044\u808c\u3078\u306e\u5f71\u97ff\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n \u3064\u307e\u308a\u3001\u9854\u306e\u305f\u308b\u307f\u3084\u305d\u308c\u304c\u539f\u56e0\u3067\u76ee\u7acb\u3064\u307b\u3046\u308c\u3044\u7dda\u3001\u3057\u308f\u306a\u3069\u306e\u539f\u56e0\u306b\u306a\u3063\u3066\u3057\u307e\u3046\u53ef\u80fd\u6027\u304c\u3042\u308b\u306e\u3067\u3059\u3002<\/p>\n \u7d2b\u5916\u7dda\u306b\u3088\u308b\u5149\u8001\u5316\u3068\u540c\u3058\u304f\u3001\u808c\u8001\u5316\u306e\u539f\u56e0\u306b\u306a\u308b\u306e\u3067\u3059\u3002<\/p>\n \u3060\u304b\u3089\u3001\u808c\u306f\u65e5\u713c\u3051\u6b62\u3081\u3092\u4f7f\u3044\u3001\u76ee\u306fUV\u30ab\u30c3\u30c8\u3068\u8fd1\u8d64\u5916\u7dda\u30ab\u30c3\u30c8\u6a5f\u80fd\u306e\u3042\u308b\u30b5\u30f3\u30b0\u30e9\u30b9\u3092\u304b\u3051\u308b\u3053\u3068\u304c\u304a\u3059\u3059\u3081\u3067\u3059\u3002<\/p>\n \uff1c\u8fd1\u8d64\u5916\u7dda\u3092\u30ab\u30c3\u30c8\u3059\u308b\u30e1\u30ac\u30cd\u306a\u3089\uff01\uff1e <\/p>\n \uff0a\u7d2b\u5916\u7dda\u30fb\u30d6\u30eb\u30fc\u30e9\u30a4\u30c8\u30fb\u8fd1\u8d64\u5916\u7dda\u3092\u30ab\u30c3\u30c8\u3059\u308b\u30a2\u30a4\u30b1\u30a2\u30e1\u30ac\u30cd\u309240\u4ee3\u7f8e\u5973\u304c\u8a66\u7740<\/a><\/p>\n \u304b\u3057\u3089\u3082\u3055\u3093\u3001\u300cHEV\u307e\u3067\u5438\u53ce\u30ab\u30c3\u30c8\uff01\u30ca\u30fc\u30eb\u30b9\u30a2\u30a4\u30b1\u30a2\u30af\u30ea\u30a2\u3092\u8a66\u3057\u3066\u307f\u307e\u3057\u305fby\u304b\u3057\u3089\u3082\u300d\u306e\u8a18\u4e8b\u57f7\u7b46\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3057\u305f\u3002<\/p>\n \u307e\u305f\u3001\u30ca\u30fc\u30eb\u30b9\u306e\u30a2\u30a4\u30b1\u30a2\u30e1\u30ac\u30cd\u306e\u30af\u30ea\u30a2\u30ec\u30f3\u30ba\u30bf\u30a4\u30d7\u306e\u7279\u5fb4\u3084\u4f7f\u7528\u611f\u3092\u4e0a\u624b\u306b\u307e\u3068\u3081\u3066\u3044\u305f\u3060\u304d\u611f\u8b1d\u7533\u3057\u4e0a\u3052\u307e\u3059\u3002<\/p>\n \u3055\u3089\u306b\u3001\u30d6\u30eb\u30fc\u30e9\u30a4\u30c8\u3084HEV\u306b\u3064\u3044\u3066\u3082\u8aac\u660e\u3044\u305f\u3060\u304d\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3057\u305f\u3002<\/p>\n \u304d\u3063\u3068\u3053\u306e\u8a18\u4e8b\u300cHEV\u307e\u3067\u5438\u53ce\u30ab\u30c3\u30c8\uff01\u30ca\u30fc\u30eb\u30b9\u30a2\u30a4\u30b1\u30a2\u30af\u30ea\u30a2\u3092\u8a66\u3057\u3066\u307f\u307e\u3057\u305fby\u304b\u3057\u3089\u3082\u300d\u304c\u30ca\u30fc\u30eb\u30b9\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u30a2\u30ab\u30c7\u30df\u30fc\u306e\u8aad\u8005\u306e\u7686\u69d8\u306b\u5f79\u7acb\u3064\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n <\/p>\n <\/p>\n \uff08\u7de8\u96c6\u30fb\u6821\u6b63\uff1a\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u30a2\u30ab\u30c7\u30df\u30fc\u7de8\u96c6\u90e8\u3000\u3084\u3059\u3060\u3068\u3082\u3088<\/a>\uff09 \u5f53\u793e\u30b9\u30bf\u30c3\u30d5\u306e\u672c\u696d\u306f\u3001\u533b\u5b66\u30fb\u85ac\u5b66\u95a2\u9023\u306e\u4e8b\u696d\u306e\u305f\u3081\u3001\u65e5\u3005\u3001\u533b\u5b66\u8ad6\u6587\u3084\u533b\u5b66\u4f1a\u306e\u767a\u8868\u306a\u3069\u306e\u6700\u65b0\u60c5\u5831\u306b\u89e6\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n \u305d\u3093\u306a\u4e2d\u3067\u3001\u300c\u3053\u308c\u306f\uff01\u300d\u3068\u3044\u3046\u3001\u307f\u306a\u3055\u307e\u306e\u5065\u5eb7\u3065\u304f\u308a\u306e\u3054\u53c2\u8003\u306b\u306a\u308b\u3088\u3046\u306a\u60c5\u5831\u3054\u7d39\u4ecb\u3057\u305f\u308a\u3001\u305d\u306e\u6642\u671f\u306b\u5408\u3063\u305f\u30b9\u30ad\u30f3\u30b1\u30a2\u3084\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u306e\u304a\u5f79\u7acb\u3061\u60c5\u5831\u3092\u30e1\u30fc\u30eb\u3067\u30b3\u30f3\u30d1\u30af\u30c8\u306b\u304a\u5c4a\u3051\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n \u305c\u3072\u3054\u767b\u9332\u3092\u304a\u5f85\u3061\u3057\u3066\u304a\u308a\u307e\u3059\u3002<\/p>\n
<\/a><\/p>\n1\uff09\u7d2b\u5916\u7dda\uff0899\uff05\u4ee5\u4e0a\uff09<\/h3>\n
2\uff09\u30d6\u30eb\u30fc\u30e9\u30a4\u30c8\uff08\u7d0428.5\uff05\uff09<\/h3>\n
3\uff09HEV\uff0897.6\uff05\u4ee5\u4e0a\uff09<\/h3>\n
2\uff0e\u30a2\u30a4\u30b1\u30a2\u30e1\u30ac\u30cd\u30af\u30ea\u30a2\u3092\u4f7f\u3063\u3066\u307f\u305f\u611f\u60f3<\/h2>\n
1\uff09\u900f\u660e\u30ec\u30f3\u30ba\u304c\u4f7f\u3044\u3084\u3059\u3044<\/h3>\n
<\/a><\/p>\n2\uff09\u65e5\u672c\u88fd\uff06\u4e08\u592b\u3001\u305a\u308c\u306b\u304f\u3044<\/h3>\n
<\/a><\/p>\n3\uff095,000\u5186\u4ee5\u4e0b\u3067\u8cfc\u5165\u53ef\u80fd<\/h3>\n
<\/a><\/p>\n3\uff0e\u3082\u30461\u3064\u306e\u6709\u5bb3\u5149\u7dda\u300c\u8fd1\u8d64\u5916\u7dda\u300d\uff08\u30ca\u30fc\u30eb\u30b9\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u30a2\u30ab\u30c7\u30df\u7de8\u96c6\u90e8\uff09<\/h2>\n
\n\uff0a\u8fd1\u8d64\u5916\u7dda\u309238.5\uff05\u30ab\u30c3\u30c8\u3059\u308b\uff01\u8d85\u8efd\u91cf\u30a2\u30a4\u30b1\u30a2\u30b0\u30e9\u30b9<\/a><\/p>\n
<\/a><\/p>\n4\uff0e\u30ca\u30fc\u30eb\u30b9\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u30a2\u30ab\u30c7\u30df\u30fc\u7de8\u96c6\u90e8\u30b3\u30e1\u30f3\u30c8<\/h2>\n
\uff1c\u53c2\u7167\u8ad6\u6587\uff1e<\/h2>\n
\r\n\r\n\u30101\u3011Mahmoud BH, Hexsel CL, Hamzavi IH, Lim HW. Effects of visible light on the skin. Photochem Photobiol. 2008;84(2):450-462. <\/a><\/cite>
\r\n\r\nPMID: 18248499 DOI: 10.1111\/j.1751-1097.2007.002
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8:<\/strong>\u53ef\u8996\u5149\u7dda\u304c\u76ae\u819a\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3092\u5305\u62ec\u7684\u306b\u89e3\u8aac\u3057\u305f\u91cd\u8981\u6587\u732e\u3002HEV(\u9ad8\u30a8\u30cd\u30eb\u30ae\u30fc\u53ef\u8996\u5149\u7dda)\u304c\u7279\u306b\u8272\u7d20\u6c88\u7740\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u3001UV\u5149\u7dda\u3068\u6bd4\u8f03\u3057\u3066\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u304c\u6301\u7d9a\u7684\u3067\u8272\u7d20\u6c88\u7740\u304c\u6700\u59273\u30f6\u6708\u7d9a\u304f\u3053\u3068\u3001\u7279\u306b\u808c\u30bf\u30a4\u30d7III\u4ee5\u4e0a\u306e\u6fc3\u3044\u808c\u8272\u3067\u9855\u8457\u3067\u3042\u308b\u3053\u3068\u3092\u5b9f\u8a3c\u3002\u8a18\u4e8b\u306eHEV\u306b\u3088\u308b\u76ae\u819a\u30c0\u30e1\u30fc\u30b8\u3068\u8272\u7d20\u6c88\u7740\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u79d1\u5b66\u7684\u6839\u62e0\u3092\u63d0\u4f9b\u3059\u308b\u57fa\u790e\u6587\u732e\u3002
\r\n\r\n\u30102\u3011Duteil L, Cardot-Leccia N, Queille-Roussel C, et al. Differences in visible light-induced pigmentation according to wavelengths: a clinical and histological study in comparison with UVB exposure. Pigment Cell Melanoma Res. 2014;27(5):822-826. <\/a><\/cite>
\r\n\r\nPMID: 24888214 DOI: 10.1111\/pcmr.12273
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8:<\/strong>\u30d6\u30eb\u30fc\u30e9\u30a4\u30c8(415nm)\u304c\u8272\u7d20\u6c88\u7740\u3092\u8a98\u5c0e\u3057\u3001\u305d\u306e\u52b9\u679c\u304c\u6ce2\u9577\u306b\u3088\u3063\u3066\u7570\u306a\u308b\u3053\u3068\u3092\u81e8\u5e8a\u7684\u30fb\u7d44\u7e54\u5b66\u7684\u306b\u5b9f\u8a3c\u3002\u7279\u306b\u808c\u30bf\u30a4\u30d7III-IV\u306b\u304a\u3044\u3066\u3001\u30d6\u30eb\u30fc\u30e9\u30a4\u30c8\u306b\u3088\u308b\u8272\u7d20\u6c88\u7740\u306fUVB\u3068\u6bd4\u8f03\u3057\u3066\u8457\u3057\u304f\u5f37\u304f\u3001\u6700\u59273\u30f6\u6708\u6301\u7d9a\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u3002\u4e00\u65b9\u3001\u8d64\u8272\u5149(630nm)\u3067\u306f\u8272\u7d20\u6c88\u7740\u3092\u8a98\u5c0e\u3057\u306a\u304b\u3063\u305f\u3002\u8a18\u4e8b\u306e\u30d6\u30eb\u30fc\u30e9\u30a4\u30c8\u306b\u3088\u308b\u8272\u7d20\u6c88\u7740\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u76f4\u63a5\u7684\u306a\u79d1\u5b66\u7684\u6839\u62e0\u3092\u63d0\u4f9b\u3059\u308b\u6587\u732e\u3002
\r\n\r\n\u30103\u3011Regazzetti C, Sormani L, Debayle D, et al. Melanocytes sense blue light and regulate pigmentation through Opsin-3. J Invest Dermatol. 2018;138(1):171-178.<\/a><\/cite>
\r\n\r\nPMID: 28842328 DOI: 10.1016\/j.jid.2017.07.833
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8:<\/strong>\u30e1\u30e9\u30ce\u30b5\u30a4\u30c8\u304cOpsin-3(OPN3)\u3092\u4ecb\u3057\u3066\u30d6\u30eb\u30fc\u30e9\u30a4\u30c8(415nm)\u3092\u611f\u77e5\u3057\u3001\u8272\u7d20\u6c88\u7740\u3092\u5236\u5fa1\u3059\u308b\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u660e\u3002\u30d6\u30eb\u30fc\u30e9\u30a4\u30c8\u304cOPN3\u3092\u6d3b\u6027\u5316\u3057\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u4f9d\u5b58\u6027\u7d4c\u8def\u3092\u4ecb\u3057\u3066CaMKII\u3001CREB\u3001ERK\u3001p38\u3092\u6d3b\u6027\u5316\u3057\u3001MITF\u306e\u30ea\u30f3\u9178\u5316\u3092\u8a98\u5c0e\u3002\u3053\u308c\u306b\u3088\u308a\u30c1\u30ed\u30b7\u30ca\u30fc\u30bc\u3068\u30c9\u30fc\u30d1\u30af\u30ed\u30fc\u30e0\u30c8\u30fc\u30c8\u30e1\u30e9\u30fc\u30bc\u306e\u8907\u5408\u4f53\u5f62\u6210\u304c\u4fc3\u9032\u3055\u308c\u3001\u7279\u306b\u808c\u30bf\u30a4\u30d7III\u4ee5\u4e0a\u3067\u6301\u7d9a\u7684\u306a\u8272\u7d20\u6c88\u7740\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u3092\u5b9f\u8a3c\u3002\u8a18\u4e8b\u306e\u30d6\u30eb\u30fc\u30e9\u30a4\u30c8\u611f\u77e5\u3068\u8272\u7d20\u6c88\u7740\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u79d1\u5b66\u7684\u6839\u62e0\u3092\u63d0\u4f9b\u3059\u308b\u91cd\u8981\u6587\u732e\u3002
\r\n\r\n\u30104\u3011Behar-Cohen F, Baillet G, de Ayguavives T, et al. Ultraviolet damage to the eye revisited: eye-sun protection factor (E-SPF\u00ae), a new ultraviolet protection label for eyewear. Clin Ophthalmol. 2014;8:87-104.<\/a><\/cite>
\r\n\r\nPMID: 24379652 DOI: 10.2147\/OPTH.S461
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8:<\/strong>\u773c\u3078\u306eUV\u66dd\u9732\u3068\u30b5\u30f3\u30b0\u30e9\u30b9\u306e\u4fdd\u8b77\u52b9\u679c\u3092\u5305\u62ec\u7684\u306b\u89e3\u8aac\u3002\u30ec\u30f3\u30ba\u306eUV\u900f\u904e\u3060\u3051\u3067\u306a\u304f\u3001\u30ec\u30f3\u30ba\u80cc\u9762\u304b\u3089\u306e\u53cd\u5c04(\u30d0\u30c3\u30af\u30ea\u30d5\u30ec\u30af\u30b7\u30e7\u30f3)\u3082\u773c\u3078\u306eUV\u66dd\u9732\u306b\u5927\u304d\u304f\u5bc4\u4e0e\u3057\u3001\u901a\u5e38\u306e\u53cd\u5c04\u9632\u6b62\u30b3\u30fc\u30c6\u30a3\u30f3\u30b0\u306fUV\u53cd\u5c04\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u3092\u5b9f\u8a3c\u3002\u30ec\u30f3\u30ba\u306e\u900f\u904e\u7387\u3068\u53cd\u5c04\u7387\u306e\u4e21\u65b9\u3092\u7d71\u5408\u3057\u305f\u65b0\u3057\u3044\u773c\u7528\u65e5\u713c\u3051\u6b62\u3081\u4fc2\u6570(E-SPF\u00ae)\u3092\u63d0\u5531\u3002\u8a18\u4e8b\u306eUV\u30ab\u30c3\u30c8\u30b5\u30f3\u30b0\u30e9\u30b9\u306e\u4fdd\u8b77\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u9078\u3073\u65b9\u306e\u79d1\u5b66\u7684\u6839\u62e0\u3092\u63d0\u4f9b\u3059\u308b\u91cd\u8981\u6587\u732e\u3002
\r\n\r\n\u30105\u3011Mann T, Eggers K, Rippke F, Tesch M, Buerger A, Darvin ME, Schanzer S, Meinke MC, Lademann J, Kolbe L. High-energy visible light at ambient doses and intensities induces oxidative stress of skin\u2014Protective effects of the antioxidant and Nrf2 inducer Licochalcone A in vitro and in vivo. Photodermatol Photoimmunol Photomed. 2020;36(2):135-145.<\/a><\/cite>
\r\n\r\nPMID: 31661571 DOI: 10.1111\/phpp.12523
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8:<\/strong>HEV\u5149(400-500nm)\u304c\u65e5\u5e38\u7684\u306a\u7167\u5c04\u91cf(\u6674\u5929\u306e\u590f\u306e\u65e5\u30011\u6642\u9593\u76f8\u5f53\u306e150 J\/cm\u00b2)\u3067\u3082\u6d3b\u6027\u9178\u7d20\u7a2e(ROS)\u3092\u8a98\u5c0e\u3057\u3001\u76ae\u819a\u306e\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u3092\u5b9f\u8a3c\u3002\u5f93\u6765\u306eUV\u30d5\u30a3\u30eb\u30bf\u30fc(SPF50+)\u3067\u306fHEV\u8a98\u5c0e\u306eROS\u3092\u9632\u3052\u306a\u3044\u304c\u3001\u6297\u9178\u5316\u6210\u5206Licochalcone A(LicA)\u306e\u524d\u51e6\u7406\u306b\u3088\u308a\u975e\u7167\u5c04\u30ec\u30d9\u30eb\u307e\u3067ROS\u751f\u6210\u3092\u6291\u5236\u3067\u304d\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u3002\u8a18\u4e8b\u306eHEV\u306b\u3088\u308b\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3068\u6297\u9178\u5316\u4fdd\u8b77\u306e\u5fc5\u8981\u6027\u306e\u79d1\u5b66\u7684\u6839\u62e0\u3092\u63d0\u4f9b\u3059\u308b\u91cd\u8981\u6587\u732e\u3002\r\n\r\n<\/pre>\n
\n\u533b\u5b66\u51fa\u7248\u793e\u3001\u533b\u5b66\u7cfb\u5e83\u544a\u4ee3\u7406\u5e97\u306b\u3066\u7de8\u96c6\u30fb\u30e9\u30a4\u30bf\u30fc\u3068\u3057\u3066\u3001\u533b\u5e2b\u5411\u3051\u3001\u60a3\u8005\u5411\u3051\u306e\u60c5\u5831\u63d0\u4f9b\u8cc7\u6750\u3084\u66f8\u7c4d\u7b49\u306e\u8a18\u4e8b\u306e\u7de8\u96c6\u30fb\u57f7\u7b46\u3084\u3001\u56fd\u5185\u30fb\u6d77\u5916\u533b\u5b66\u4f1a\u53d6\u6750\u30fb\u8a18\u4e8b\u57f7\u7b46\u3092\u884c\u3046\u3002<\/p>\n