{"id":66848,"date":"2025-12-26T11:00:40","date_gmt":"2025-12-26T02:00:40","guid":{"rendered":"https:\/\/www.nahls.co.jp\/eijingukea\/?p=66848"},"modified":"2025-12-26T21:14:41","modified_gmt":"2025-12-26T12:14:41","slug":"nahlspure_35","status":"publish","type":"post","link":"https:\/\/www.nahls.co.jp\/eijingukea\/evidences\/hiroba\/nahlspure_35\/","title":{"rendered":"\u65b0\u3057\u304f\u306a\u3063\u305f\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u30ed\u30fc\u30b7\u30e7\u30f3\u4f7f\u7528\u3057\u3066\u307f\u307e\u3057\u305f\uff01 by\u305f\u307e\u3054\u3061\u3083\u3093"},"content":{"rendered":"
\n

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1.\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u3092\u4f7f\u3063\u305f\u79c1\u306e\u611f\u60f3\u306f\uff1f<\/h2>\n

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\n\u3042\u30fc\uff01\uff01\u304a\u808c\u306b\u826f\u3044\u3093\u3060\u306a\u30fc\u3063\u3066\u6c17\u5206\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n

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\n\u4f7f\u7528\u611f\u7684\u306b\u3082\u3001\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u306f\u5316\u7ca7\u6c34\u3068\u3057\u3066\u3001\u3044\u3064\u3082\u306e\u7f8e\u5bb9\u6db2\u3084\u30af\u30ea\u30fc\u30e0\u306e\u524d\u306b\u307e\u305a\u4f7f\u7528\u3057\u3066\u307f\u3066\u307b\u3057\u3044\u3067\u3059\u3002\uff01<\/p>\n

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2\uff0e\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u306e\u30e1\u30a4\u30f3\u306e\u6210\u5206\u306f\u300c\u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\u300d<\/h2>\n

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1\uff09\u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\u3068\u306f\uff1f<\/h3>\n

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2\uff09\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u306e\u7279\u5fb4<\/h3>\n

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\n\uff0a\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9<\/a><\/p>\n

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\n\uff0a\u5fb9\u5e95\u89e3\u5256\uff01\u65b0\u3057\u3044\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u306f\u3053\u3053\u304c\u9055\u3046\uff01\u307f\u3093\u306a\u306e\u611f\u60f3\u306f\uff1f<\/a><\/p>\n

3\uff0e\u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\u304c\u5897\u3084\u3059\u30d2\u30fc\u30c8\u30b7\u30e7\u30c3\u30af\u30d7\u30ed\u30c6\u30a4\u30f3\u306e\u306f\u305f\u3089\u304d\uff08\u30ca\u30fc\u30eb\u30b9\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u30a2\u30ab\u30c7\u30df\u30fc\u7de8\u96c6\u90e8\uff09<\/h2>\n

\u3042\u4eca\u56de\u3001\u305f\u307e\u3054\u3061\u3083\u3093\u3055\u3093\u306b\u306f\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u3084\u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\u306b\u3064\u3044\u3066\u3054\u7d39\u4ecb\u3044\u305f\u3060\u304d\u307e\u3057\u305f\u3002
\n\u3053\u3053\u3067\u306f\u3001\u305d\u306e\u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\u304c\u5897\u3084\u3059\u30d2\u30fc\u30c8\u30b7\u30e7\u30c3\u30af\u30d7\u30ed\u30c6\u30a4\u30f3\u306b\u3064\u3044\u3066\u3082\u3046\u5c11\u3057\u8aac\u660e\u3092\u52a0\u3048\u307e\u3059\u3002<\/p>\n

\u3053\u306eHSP\uff08\u30d2\u30fc\u30c8\u30b7\u30e7\u30c3\u30af\u30d7\u30ed\u30c6\u30a4\u30f3\uff09\u3068\u306f\u3001\u300c\u71b1\u30b7\u30e7\u30c3\u30af\u305f\u3093\u3071\u304f\u8cea\u300d\u3068\u3082\u547c\u3070\u308c\u307e\u3059\u3002
\n\u4eba\u9593\u306e\u7d30\u80de\u306e\u306a\u304b\u306b\u3042\u308b\u305f\u3093\u3071\u304f\u8cea\u306e\u3072\u3068\u3064\u3067\u3001\u4ed6\u306e\u305f\u3093\u3071\u304f\u8cea\u3092\u4fee\u5fa9\u3057\u3088\u3046\u3068\u306f\u305f\u3089\u304d\u307e\u3059\u3002<\/p>\n

\u79c1\u305f\u3061\u306e\u304b\u3089\u3060\u306f\u3001\u76ae\u819a\u3084\u7b4b\u8089\u3001\u8840\u7ba1\u306a\u3069\u3001\u3042\u3089\u3086\u308b\u7d44\u7e54\u3084\u7d30\u80de\u306f\u305f\u3093\u3071\u304f\u8cea\u304b\u3089\u3067\u304d\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u3057\u304b\u3057\u3001\u7d2b\u5916\u7dda\u3084\u30a6\u30a3\u30eb\u30b9\u3001\u6c17\u6e29\u306e\u5909\u5316\u3001\u7cbe\u795e\u7684\u30b9\u30c8\u30ec\u30b9\u306a\u3069\u3092\u53d7\u3051\u308b\u3068\u3001\u305f\u3093\u3071\u304f\u8cea\u304c\u50b7\u3064\u3044\u3066\u6b63\u5e38\u306a\u306f\u305f\u3089\u304d\u304c\u3067\u304d\u306a\u304f\u306a\u3063\u3066\u3057\u307e\u3044\u307e\u3059\u3002
\nHSP\uff08\u30d2\u30fc\u30c8\u30b7\u30e7\u30c3\u30af\u30d7\u30ed\u30c6\u30a4\u30f3\uff09\u306f\u305d\u3093\u306a\u7d30\u80de\u3092\u4fee\u5fa9\u3059\u308b\u306e\u3067\u3059\u3002<\/p>\n

HSP\uff08\u30d2\u30fc\u30c8\u30b7\u30e7\u30c3\u30af\u30d7\u30ed\u30c6\u30a4\u30f3\uff09\u306f\u305f\u304f\u3055\u3093\u3042\u308a\u307e\u3059\u304c\u3001\u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\u304c\u5897\u3084\u3059\u306e\u304cHSP47\u3068HSP70\u3067\u3059\u3002<\/p>\n

1\uff09HSP\uff08\u30d2\u30fc\u30c8\u30b7\u30e7\u30c3\u30af\u30d7\u30ed\u30c6\u30a4\u30f3\uff0947<\/h3>\n

HSP47\u306f\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u3068\u7d50\u3073\u3064\u3044\u3066\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u3092\u6b63\u3057\u3044\u5f62\u306b\u5c0e\u304d\u3001\u8cea\u306e\u9ad8\u3044\u30b3\u30e9\u30fc\u30b2\u30f3\u306b\u3059\u308b\u306e\u3092\u52a9\u3051\u308b\u306f\u305f\u3089\u304d\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

\u7f8e\u808c\u306e\u305f\u3081\u306b\u306f\u30b3\u30e9\u30fc\u30b2\u30f3\u3092\u6b63\u3057\u3044\u5f62\u306b\u3059\u308b\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u304c\u3001HSP47\u304c\u305d\u308c\u3092\u52a9\u3051\u308b\u306e\u3067\u3059\u3002<\/p>\n

2\uff09HSP70<\/h3>\n

HSP70\u306f\u3001\u30e1\u30e9\u30cb\u30f3\u3092\u6291\u3048\u308b\u3053\u3068\u3067\u7d2b\u5916\u7dda\u30c0\u30e1\u30fc\u30b8\u3092\u9632\u304e\u307e\u3059\u3002<\/p>\n

\u3064\u307e\u308a\u3001\u30b7\u30ef\u3084\u30b7\u30df\u306a\u3069\u306e\u304a\u808c\u306e\u8001\u5316\u3092\u9632\u3044\u3067\u304f\u308c\u308b\u30d2\u30fc\u30c8\u30b7\u30e7\u30c3\u30af\u30d7\u30ed\u30c6\u30a4\u30f3\u3067\u3059\u3002<\/p>\n

\u307e\u305f\u3001HSP70\u306f\u3001\u8133\u306e\u30b9\u30c8\u30ec\u30b9\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3059\u308b\u6307\u4ee4\u5854\u306b\u306f\u305f\u3089\u304d\u304b\u3051\u307e\u3059\u3002
\n\u305d\u306e\u7d50\u679c\u3001\u30ce\u30f3\u30ec\u30e0\u7761\u7720\u306e\u6642\u9593\u3092\u9577\u304f\u3059\u308b\u306f\u305f\u3089\u304d\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

\u3064\u307e\u308a\u3001HSP70\u306f\u8cea\u306e\u9ad8\u3044\u7761\u7720\u3092\u3082\u305f\u3089\u3059\u3053\u3068\u3067\u3082\u7f8e\u808c\u3092\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u306e\u3067\u3059\u3002<\/p>\n

\uff1cHSP\uff08\u30d2\u30fc\u30c8\u30b7\u30e7\u30c3\u30af\u30d7\u30ed\u30c6\u30a4\u30f3\uff09\u306e\u53c2\u8003\u60c5\u5831\uff1e
\n\uff0a\u30b7\u30df\u3092\u4e88\u9632\u3059\u308bHSP\uff08\u30d2\u30fc\u30c8\u30b7\u30e7\u30c3\u30af\u30d7\u30ed\u30c6\u30a4\u30f3\uff09\u306e\u52b9\u679c\u3068\u306f\uff1f<\/a><\/p>\n

\uff0a\u30d2\u30fc\u30c8\u30b7\u30e7\u30c3\u30af\u30d7\u30ed\u30c6\u30a4\u30f3(HSP)47\u306f\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u306b\u5927\u5207\u306a\u6210\u5206<\/a><\/p>\n

\uff0aHSP\uff08\u30d2\u30fc\u30c8\u30b7\u30e7\u30c3\u30af\u30d7\u30ed\u30c6\u30a4\u30f3\uff09\u3092\u5897\u3084\u30597\u3064\u306e\u65b9\u6cd5\u3067\u7f8e\u808c\u3078\uff01<\/a><\/p>\n

\uff0aHSP(\u30d2\u30fc\u30c8\u30b7\u30e7\u30c3\u30af\u30d7\u30ed\u30c6\u30a4\u30f3)\u3067\u30b7\u30ef\u3084\u307b\u3046\u308c\u3044\u7dda\u304c\u4e88\u9632\u3067\u304d\u308b\uff01<\/a><\/p>\n

\uff1c\u5316\u7ca7\u6c34\u306e\u9078\u3073\u65b9\u3084\u4f7f\u3044\u65b9\u306e\u53c2\u8003\u8a18\u4e8b\uff1e
\n\uff0a\u5316\u7ca7\u6c34\u30e9\u30f3\u30ad\u30f3\u30b0\u3092\u8d85\u3048\u308b\uff01\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u5316\u7ca7\u6c34\u306e\u9078\u3073\u65b9<\/a><\/p>\n

\uff0a\u304a\u3059\u3059\u3081\u306e\u654f\u611f\u808c\u5316\u7ca7\u6c34\uff01\u9078\u3073\u65b9\u306f\u30e9\u30f3\u30ad\u30f3\u30b0\u3088\u308a\u523a\u6fc0\u6210\u5206\u3092\u907f\u3051\u308b<\/a><\/p>\n

\uff0a\u30a2\u30eb\u30b3\u30fc\u30eb\u30d5\u30ea\u30fc\u5316\u7ca7\u6c34\u3067\u6f64\u3044\u7d20\u808c\u3078\uff01\u5931\u6557\u3057\u306a\u3044\u9078\u3073\u65b9\u306e3\u3064\u306e\u30b3\u30c4<\/a><\/p>\n

\uff0a\u30a2\u30df\u30ce\u9178\u5316\u7ca7\u6c34\u3067\u7f8e\u808c\u306b\u306a\u308b\uff01\u52b9\u679c\u3068\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u306e\u30e1\u30ea\u30c3\u30c8\u306f\uff1f<\/a><\/p>\n

\uff1c\u53c2\u8003\u66f8\u7c4d\uff1e
\n\uff0a\u30d2\u30fc\u30c8\u30b7\u30e7\u30c3\u30af\u30d7\u30ed\u30c6\u30a4\u30f3\u52a0\u6e29\u5065\u5eb7\u6cd5\uff08\u4f0a\u85e4\u8981\u5b50\u3000\u8457\u3001\u682a\u5f0f\u4f1a\u793e\u6cd5\u7814\uff09<\/a><\/p>\n

\uff0a42\u2103\u6e29\u3081\u3067\u7d20\u808c\u7f8e\u4eba\uff08\u6c34\u5cf6\u5fb9\u3000\u8457\u3001\u682a\u5f0f\u4f1a\u793e\u5e7b\u51ac\u820e\uff09<\/a><\/p>\n

\uff0a\u7f8e\u4eba\u306b\u5316\u7ca7\u6c34\u306f\u3044\u3089\u306a\u3044\uff08\u5409\u6728\u4f38\u5b50\u3000\u8457\u3001\u8b1b\u8ac7\u793e\uff09<\/a><\/p>\n

4\uff0e\u30ca\u30fc\u30eb\u30b9\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u30a2\u30ab\u30c7\u30df\u30fc\u7de8\u96c6\u90e8\u30b3\u30e1\u30f3\u30c8<\/h2>\n

\u305f\u307e\u3054\u3061\u3083\u3093\u3055\u3093\u3001\u65b0\u3057\u3044\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u306e\u8a18\u4e8b\u57f7\u7b46\u3001\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3057\u305f\u3002<\/p>\n

\u30ca\u30fc\u30eb\u30b9\u306e\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u5316\u7ca7\u54c1\u3092\u4f7f\u3046\u306e\u304c\u521d\u3081\u3066\u306e\u305f\u307e\u3054\u3061\u3083\u3093\u3055\u3093\u3002
\n\u3082\u3061\u308d\u3093\u3001\u3053\u308c\u304c\u521d\u3081\u3066\u3054\u57f7\u7b46\u3044\u305f\u3060\u3044\u305f\u8a18\u4e8b\u3067\u3059\u3002<\/p>\n

\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u3092\u4f7f\u3063\u305f\u611f\u60f3\u3001\u304a\u3059\u3059\u3081\u306e\u4f7f\u3044\u304b\u305f\u306a\u3069\u306b\u52a0\u3048\u3066\u3001\u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\u30f3\u306e\u7279\u5fb4\u3082\u3054\u7d39\u4ecb\u3044\u305f\u3060\u304d\u307e\u3057\u305f\u3002
\n\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3057\u305f\u3002<\/p>\n

\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u304c\u305f\u307e\u3054\u3061\u3083\u3093\u3055\u3093\u306e\u4e7e\u71e5\u808c\u306e\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u306b\u304a\u5f79\u306b\u7acb\u3063\u305f\u3088\u3046\u3067\u3046\u308c\u3057\u3044\u3067\u3059\u3002<\/p>\n

\u304d\u3063\u3068\u305f\u307e\u3054\u3061\u3083\u3093\u3055\u3093\u306e\u57f7\u7b46\u3044\u305f\u3060\u3044\u305f\u3053\u306e\u8a18\u4e8b\u300c\u65b0\u3057\u304f\u306a\u3063\u305f\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u30ed\u30fc\u30b7\u30e7\u30f3\u4f7f\u7528\u3057\u3066\u307f\u307e\u3057\u305f\uff01\u3000By \u305f\u307e\u3054\u3061\u3083\u3093\u300d\u304c\u30ca\u30fc\u30eb\u30b9\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u30a2\u30ab\u30c7\u30df\u30fc\u306e\u8aad\u8005\u306e\u7686\u69d8\u306b\u5f79\u7acb\u3064\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n

\u308f\u305f\u3057\u305f\u3061\u306f\u3001\u30ca\u30fc\u30eb\u30b9\u306e\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u5316\u7ca7\u54c1\u3092\u901a\u3057\u3066\u591a\u304f\u306e\u5973\u6027\u306e\u7f8e\u808c\u3092\u5fdc\u63f4\u3067\u304d\u308c\u3070\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n

 <\/p>\n

\uff1c\u53c2\u7167\u8ad6\u6587\uff1e<\/h2>\n
\r\n\u30101\u3011Robinson LR, Fitzgerald NC, Doughty DG, Dawes NC, Berge CA, Bissett DL.\r\nTopical palmitoyl pentapeptide provides improvement in photoaged human facial skin.\r\nInt J Cosmet Sci. 2005 Jun;27(3):155\u2013160.<\/a><\/cite>
\r\n\r\nPMID: 18492182 DOI: 10.1111\/j.1467-2494.2005.00261.x
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u30b7\u30b0\u30ca\u30eb\u30da\u30d7\u30c1\u30c9\uff08Pal-KTTKS\uff09\u5916\u7528\u306e\u81e8\u5e8a\u7814\u7a76\u3002\u7d99\u7d9a\u4f7f\u7528\u3067\u5149\u8001\u5316\u306b\u4f34\u3046\u5c0f\u3058\u308f\u306a\u3069\u304c\u6539\u5584\u3057\u3001\u30da\u30d7\u30c1\u30c9\u7cfb\u6210\u5206\u304c\u30cf\u30ea\u30fb\u3057\u308f\u30b1\u30a2\u306b\u5bc4\u4e0e\u3059\u308b\u53ef\u80fd\u6027\u3092\u793a\u3057\u305f\u3002
\r\n\r\n\u30102\u3011Bissett DL, Oblong JE, Berge CA.Niacinamide: A B vitamin that improves aging facial skin appearance.Dermatol Surg. 2005;31(7 Pt 2):860\u2013865.<\/a><\/cite>
\r\n\r\nPMID: 16029679\u3000DOI: 10.1111\/j.1524-4725.2005.31726
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u5916\u7528\u306b\u3088\u308a\u3001\u5c0f\u3058\u308f\u3001\u8272\u30e0\u30e9\u3001\u9ec4\u3050\u3059\u307f\u3001\u30d0\u30ea\u30a2\u6a5f\u80fd\u304c\u6539\u5584\u3002\u30bb\u30e9\u30df\u30c9\u5408\u6210\u4fc3\u9032\u3084\u708e\u75c7\u6291\u5236\u3092\u901a\u3058\u3066\u3001\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u3068\u7f8e\u767d\u306e\u4e21\u9762\u3067\u6709\u7528\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u4ee3\u8868\u7684\u7814\u7a76\u3002
\r\n\r\n\u30103\u3011Pullar JM, Carr AC, Vissers MCM.The Roles of Vitamin C in Skin Health.Nutrients. 2017;9(8):866.<\/a><\/cite>
\r\n\r\nPMID: 28805671DOI: 10.3390\/nu9080866
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u30d3\u30bf\u30df\u30f3C\u306f\u30b3\u30e9\u30fc\u30b2\u30f3\u5408\u6210\u3001\u6297\u9178\u5316\u3001\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u6291\u5236\u306b\u95a2\u4e0e\u3059\u308b\u91cd\u8981\u6210\u5206\u3002\u5916\u7528\u30d3\u30bf\u30df\u30f3C\u304a\u3088\u3073\u8a98\u5c0e\u4f53\u304c\u3001\u5149\u8001\u5316\u3084\u30b7\u30df\u5bfe\u7b56\u306b\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u3092\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u6574\u7406\u3057\u305f\u7dcf\u8aac\u3002
\r\n\r\n\u30104\u3011Bai X-D, Liu Y-C, Ge S-Y, Fei W-C.Clinical Trial of Salmon Nasal Cartilage-Derived Proteoglycans on Human Facial Antiaging: A Randomized, Double-Blind, Placebo-Controlled Study.J Cosmet Dermatol. 2025 Jul;24(7):e70218.<\/a><\/cite>
\r\n\r\nPMID: 40613544 DOI: 10.1111\/jocd.70218
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u30b5\u30b1\u9f3b\u8edf\u9aa8\u7531\u6765\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u309256\u65e5\u9593\u6442\u53d6\u3057\u305f\u4e8c\u91cd\u76f2\u691cRCT\u3002\u30d7\u30e9\u30bb\u30dc\u6bd4\u3067\u808c\u306e\u5f3e\u529b\u30fb\u6c34\u5206\u304c\u6539\u5584\u3057\u3001\u7c97\u3055\u30fb\u3057\u308f\u30fb\u30e1\u30e9\u30cb\u30f3\u91cf\u30fb\u30d6\u30e9\u30a6\u30f3\u30b9\u30dd\u30c3\u30c8\u304c\u6e1b\u5c11\u3002\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u306e\u201c\u808c\u30b3\u30f3\u30c7\u30a3\u30b7\u30e7\u30f3\u6539\u5584\u201d\u6839\u62e0\u3068\u3057\u3066\u4f7f\u3044\u3084\u3059\u3044\u3002
\r\n\r\n\u30105\u3011Rawlings AV, Harding CR.Moisturization and skin barrier function.Dermatol Ther. 2004;17 Suppl 1:43\u201348. <\/a><\/cite>
\r\n\r\nPMID: 14728698 DOI: 10.1111\/j.1396-0296.2004.04s1005.x
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u89d2\u8cea\u5c64\u306e\u4fdd\u6e7f\u3068\u30d0\u30ea\u30a2\u6a5f\u80fd\u306e\u7dcf\u8aac\u3002NMF\uff08PCA\u306a\u3069\u306e\u30a2\u30df\u30ce\u9178\u7531\u6765\u6210\u5206\uff09\u3084\u7d30\u80de\u9593\u8102\u8cea\u304c\u6c34\u5206\u4fdd\u6301\u306b\u91cd\u8981\u3067\u3001\u5316\u7ca7\u6c34\u30fb\u4fdd\u6e7f\u5264\u306f\u300c\u6c34\u3092\u4e0e\u3048\u308b\u300d\u3060\u3051\u3067\u306a\u304f\u300c\u4fdd\u6301\u3067\u304d\u308b\u89d2\u8cea\u74b0\u5883\u3092\u4f5c\u308b\u300d\u8a2d\u8a08\u304c\u8981\u70b9\u3068\u6574\u7406\u3002
\r\n\r\n\u30106\u3011Draelos ZD.The science behind skin care: Moisturizers.J Cosmet Dermatol. 2018;17(2):138\u2013144.<\/a><\/cite>
\r\n\r\nPMID: 29319217 DOI: 10.1111\/jocd.12490
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u4fdd\u6e7f\u5264\uff08\u5316\u7ca7\u6c34\uff5e\u4e73\u6db2\u30fb\u30af\u30ea\u30fc\u30e0\u542b\u3080\uff09\u306e\u79d1\u5b66\u3092\u6574\u7406\u3002\u30d2\u30e5\u30fc\u30e1\u30af\u30bf\u30f3\u30c8\uff08\u30b0\u30ea\u30bb\u30ea\u30f3\u7b49\uff09\uff0b\u30a8\u30e2\u30ea\u30a8\u30f3\u30c8\uff0b\u30aa\u30af\u30eb\u30fc\u30b7\u30d6\u306e\u7d44\u307f\u5408\u308f\u305b\u3001\u523a\u6fc0\u6027\u3001\u808c\u72b6\u614b\u306b\u5408\u308f\u305b\u305f\u9078\u629e\u304c\u91cd\u8981\u3067\u3001\u201c\u5316\u7ca7\u6c34\u9078\u3073\u306e\u8ef8\uff08\u4fdd\u6e7f\u30fb\u30d0\u30ea\u30a2\u30fb\u523a\u6fc0\uff09\u201d\u306e\u6839\u62e0\u306b\u306a\u308b\u3002
\r\n\r\n\u30107\u3011Verdier-S\u00e9vrain S, Bont\u00e9 F.Skin hydration: a review on its molecular mechanisms. J Cosmet Dermatol. 2007 Jun;6(2):75\u201382.<\/a><\/cite>
\r\n\r\nPMID: 17524122 DOI: 10.1111\/j.1473-2165.2007.00300.x
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u76ae\u819a\u306e\u3046\u308b\u304a\u3044\u306f\u89d2\u8cea\u306e\u69cb\u9020\u30fbNMF\u30fb\u8102\u8cea\u30fb\u6c34\u5206\u79fb\u52d5\u304c\u9023\u52d5\u3057\u3066\u7dad\u6301\u3055\u308c\u308b\u3068\u89e3\u8aac\u3002\u7279\u306b\u30b0\u30ea\u30bb\u30ea\u30f3\u306a\u3069\u306e\u4fdd\u6e7f\u56e0\u5b50\u306e\u91cd\u8981\u6027\u3001\u4e7e\u71e5\u3067\u843d\u5c51\u304c\u9032\u3080\u6a5f\u5e8f\u3092\u6574\u7406\u3057\u3001\u201c\u3046\u308b\u304a\u3044\u3092\u4fdd\u3064\u5316\u7ca7\u6c34\u30fb\u4fdd\u6e7f\u8a2d\u8a08\u201d\u306e\u7406\u8ad6\u80cc\u666f\u3068\u3057\u3066\u5f15\u7528\u3057\u3084\u3059\u3044\u3002
\r\n\r\n\u30108\u3011 Kim YJ, Seo DH, Lee SH, et al.Conditioned media from human umbilical cord blood-derived mesenchymal stem cells stimulate rejuvenation function in human skin.Biochem Biophys Rep. 2018;16:96\u2013102.<\/a><\/cite>
\r\n\r\nPMID: 30417126 DOI: 10.1016\/j.bbrep.2018.10.007
\r\n\r\nPMCID: PMC6205340
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u30d2\u30c8\u81cd\u5e2f\u8840\u7531\u6765\u9593\u8449\u7cfb\u5e79\u7d30\u80de\u304b\u3089\u5f97\u305f\u57f9\u990a\u4e0a\u6e05\u6db2\uff08conditioned media; USC-CM\uff09\u306b\u306f\u3001EGF\u3001bFGF\u3001PDGF\u3001HGF\u3001GDF-11\u306a\u3069\u306e\u808c\u518d\u751f\u95a2\u9023\u6210\u9577\u56e0\u5b50\u304c\u8c4a\u5bcc\u306b\u542b\u307e\u308c\u3066\u3044\u308b\u3002in vitro \u3067\u306f\u7dda\u7dad\u82bd\u7d30\u80de\u306e\u5897\u6b96\u30fb\u7d30\u80de\u5916\u30de\u30c8\u30ea\u30c3\u30af\u30b9\uff08ECM\uff09\u751f\u6210\u3092\u4fc3\u9032\u3057\u3001in vivo\uff08\u5065\u5e38\u5973\u6027\uff09\u3067\u306e\u5916\u7528\u3067\u306f\u76ae\u819a\u5bc6\u5ea6\u5897\u52a0\u30fb\u30b7\u30ef\u6539\u5584\u7b49\u306e\u201c\u808c\u82e5\u8fd4\u308a\u52b9\u679c\u201d\u304c\u8a8d\u3081\u3089\u308c\u305f\u3002\u5e79\u7d30\u80de\u305d\u306e\u3082\u306e\u3067\u306f\u306a\u304f\u3001\u5206\u6ccc\u56e0\u5b50\u306b\u3088\u308b\u30d1\u30e9\u30af\u30e9\u30a4\u30f3\u4f5c\u7528\u306b\u3088\u308b\u808c\u30b3\u30f3\u30c7\u30a3\u30b7\u30e7\u30f3\u6539\u5584\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002
\r\n\r\n\u30109\u3011 Kato E, Sasaki Y, Takahashi N.Sodium dl-\u03b1-tocopheryl-6-O-phosphate inhibits PGE\u2082 production in keratinocytes induced by UVB, IL-1\u03b2 and peroxidants.Bioorg Med Chem. 2011;19(21):6348-6355.<\/a><\/cite>
\r\n\r\nPMID: 21945458 DOI: 10.1016\/j.bmc.2011.08.067
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u6c34\u6eb6\u6027\u30d3\u30bf\u30df\u30f3E\u8a98\u5c0e\u4f53\u3067\u3042\u308b\u30c8\u30b3\u30d5\u30a7\u30ea\u30eb-6-O-\u30ea\u30f3\u9178\u30ca\u30c8\u30ea\u30a6\u30e0\u306f\u30013D\u30d2\u30c8\u76ae\u819a\u30e2\u30c7\u30eb\u3084\u57f9\u990a\u89d2\u5316\u7d30\u80de\u306b\u304a\u3044\u3066\u3001\u7d2b\u5916\u7dda\u3084\u708e\u75c7\u523a\u6fc0\uff08IL-1\u03b2\u30fb\u9178\u5316\u30b9\u30c8\u30ec\u30b9\uff09\u306b\u3088\u308b\u708e\u75c7\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc\uff08PGE\u2082\uff09\u7523\u751f\u3092\u6291\u5236\u3057\u305f\u3002\u3053\u308c\u306f \u708e\u75c7\u306b\u3088\u308b\u30c0\u30e1\u30fc\u30b8\u8efd\u6e1b\u3084\u30d0\u30ea\u30a2\u6a5f\u80fd\u7dad\u6301 \u306b\u95a2\u9023\u3057\u3001\u5916\u7528\u5316\u7ca7\u54c1\u6210\u5206\u3068\u3057\u3066\u6297\u708e\u75c7\u30fb\u6297\u9178\u5316\u4f5c\u7528\u306e\u79d1\u5b66\u7684\u6839\u62e0\u3068\u306a\u308b\u3002
\r\n\r\n<\/pre>\n
 <\/p>\n
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\n\u533b\u5b66\u51fa\u7248\u793e\u3001\u533b\u5b66\u7cfb\u5e83\u544a\u4ee3\u7406\u5e97\u306b\u3066\u7de8\u96c6\u30fb\u30e9\u30a4\u30bf\u30fc\u3068\u3057\u3066\u3001\u533b\u5e2b\u5411\u3051\u3001\u60a3\u8005\u5411\u3051\u306e\u60c5\u5831\u63d0\u4f9b\u8cc7\u6750\u3084\u66f8\u7c4d\u7b49\u306e\u8a18\u4e8b\u306e\u7de8\u96c6\u30fb\u57f7\u7b46\u3084\u3001\u56fd\u5185\u30fb\u6d77\u5916\u533b\u5b66\u4f1a\u53d6\u6750\u30fb\u8a18\u4e8b\u57f7\u7b46\u3092\u884c\u3046\u3002<\/p>\n
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