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\u3082\u30461\u3064\u306e\u30a6\u30a3\u30eb\u30d6\u30e9\u30a4\u30c9S-753\u306e\u7279\u5fb4\u306f\u3001\u6c34\u6eb6\u6027\u30d3\u30bf\u30df\u30f3C\u8a98\u5c0e\u4f53\u306a\u3069\u306e\u7d4c\u76ae\u5438\u53ce\u3092\u4fc3\u9032\u3055\u305b\u308b\u52b9\u679c\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u306f\u3001\u30b0\u30ea\u30bb\u30ea\u30f3\u3068\u306e\u76f8\u4e57\u52b9\u679c\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n \u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u306b\u306f\u3001\u30b0\u30ea\u30bb\u30ea\u30f3\u3068\u6c34\u6eb6\u6027\u30d3\u30bf\u30df\u30f3\uff23\u8a98\u5c0e\u4f53\u3067\u3042\u308b\u30a2\u30b9\u30b3\u30eb\u30d3\u30eb\u30ea\u30f3\u9178\u30ca\u30c8\u30ea\u30a6\u30e0\u3092\u914d\u5408\u3057\u3066\u3044\u308b\u306e\u3067\u3001\u76f8\u4e57\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/p>\n \u3060\u304b\u3089\u3001\u4e7e\u71e5\u808c\u5bfe\u7b56\u304b\u3089\u30a8\u30a4\u30b8\u30f3\u30b0\u30b5\u30a4\u30f3\u306e\u4e88\u9632\u306a\u3069\u306b\u3082\u52b9\u679c\u7684\u3067\u3059\u3002<\/p>\n \u3072\u308d\u3055\u3093\u306e\u304a\u6c17\u306b\u5165\u308a\u306e\u5316\u7ca7\u6c34\u306f\u3001\u540c\u3058\u30b7\u30ea\u30fc\u30ba\u306e\u4e2d\u3067\u300c\u3055\u3063\u3071\u308a\u30bf\u30a4\u30d7\u300d\u3068\u300c\u3057\u3063\u3068\u308a\u30bf\u30a4\u30d7\u300d\u304c\u3042\u308b\u3068\u306e\u3053\u3068\u3002<\/p>\n \u4e00\u65b9\u3001\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u306f\u3001\u3055\u3063\u3071\u308a\u30bf\u30a4\u30d7\u3002<\/p>\n \u611f\u899a\u7684\u306b\u306f\u3001\u300c\u3055\u3063\u3071\u308a\u30bf\u30a4\u30d7\u300d\u3088\u308a\u300c\u3057\u3063\u3068\u308a\u30bf\u30a4\u30d7\u300d\u306e\u65b9\u304c\u4fdd\u6e7f\u529b\u304c\u9ad8\u3044\u6c17\u304c\u3057\u307e\u3059\u306d\u3002<\/p>\n 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\u3060\u304b\u3089\u3001\u6700\u8fd1\u306e\u4fdd\u6e7f\u5316\u7ca7\u6c34\u3084\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u5316\u7ca7\u6c34\u3067\u306f\u30b5\u30c3\u30d1\u30ea\u3057\u3066\u3044\u3066\u3082\u3001\u4fdd\u6e7f\u529b\u304c\u305f\u304b\u3044\u3082\u306e\u3082\u3042\u308b\u306e\u3067\u3059\u3002<\/p>\n \u3072\u308d\u3055\u3093\u3001\u300c\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u300d\u306b\u3064\u3044\u3066\u306e\u8a18\u4e8b\u3092\u3054\u57f7\u7b46\u3044\u305f\u3060\u304d\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3057\u305f\u3002<\/p>\n \u307e\u305f\u3001\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u306b\u914d\u5408\u3055\u308c\u3066\u3044\u308b\u6210\u5206\u3084\u305d\u306e\u52b9\u679c\u3001\u305d\u3057\u3066\u4f7f\u7528\u611f\u3082\u8a73\u3057\u304f\u3054\u7d39\u4ecb\u3044\u305f\u3060\u304d\u307e\u3057\u305f\u3002<\/p>\n 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<\/a><\/p>\n
<\/a><\/p>\n
\n2\uff0e\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u3063\u3066\u4f55\u304c\u753b\u671f\u7684\u306a\u306e\u304b\u8abf\u3079\u3066\u307f\u305f<\/h2>\n
<\/a><\/p>\n\n
\n3\uff0e\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u5316\u7ca7\u6c34\u300c\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u300d\u3092\u6bce\u671d\u6bce\u6669\u4f7f\u3063\u3066\u307f\u307e\u3057\u305f\uff01<\/h2>\n
<\/a><\/p>\n
\n4\uff0e\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u306e\u4fdd\u6e7f\u529b\u306e\u79d8\u5bc6(\u30ca\u30fc\u30eb\u30b9\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u30a2\u30ab\u30c7\u30df\u30fc\u7de8\u96c6\u90e8\uff09<\/h2>\n
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\uff1c\u53c2\u7167\u8ad6\u6587\uff1e<\/h2>\n
\r\n\u30101\u3011Robinson LR, Fitzgerald NC, Doughty DG, Dawes NC, Berge CA, Bissett DL. Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin. Int J Cosmet Sci. 2005;27(3):155\u2013160.<\/a><\/cite>
\r\n\r\nPMID: 18492182\u3000DOI: 10.1111\/j.1467-2494.2005.00261.x
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u30b7\u30b0\u30ca\u30eb\u30da\u30d7\u30c1\u30c9\uff08Pal-KTTKS\uff09\u5916\u7528\u306e\u81e8\u5e8a\u7814\u7a76\u3002\u7d99\u7d9a\u4f7f\u7528\u3067\u5149\u8001\u5316\u306b\u4f34\u3046\u5c0f\u3058\u308f\u7b49\u306e\u6539\u5584\u304c\u5831\u544a\u3055\u308c\u3001\u30cf\u30ea\u30fb\u3057\u308f\u30b1\u30a2\u3092\u72d9\u3046\u5316\u7ca7\u6c34\u8a2d\u8a08\uff08\u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\u306e\u3088\u3046\u306a\u30da\u30d7\u30c1\u30c9\u7cfb\u6210\u5206\u306e\u4f4d\u7f6e\u3065\u3051\uff09\u306e\u6839\u62e0\u3068\u306a\u308b\u3002
\r\n\r\n\u30102\u3011Bissett DL, Oblong JE, Berge CA. Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatol Surg. 2005;31(7 Pt 2):860\u2013865.<\/a><\/cite>
\r\n\r\nPMID: 16029679\u3000DOI: 10.1111\/j.1524-4725.2005.31726
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u5916\u7528\u306b\u3088\u308a\u3001\u5c0f\u3058\u308f\u3001\u8272\u30e0\u30e9\u3001\u9ec4\u3050\u3059\u307f\u3001\u5f3e\u529b\u306a\u3069\u306e\u898b\u305f\u76ee\u6307\u6a19\u304c\u6539\u5584\u3002\u30a8\u30a4\u30b8\u30f3\u30b0\u30b5\u30a4\u30f3\u306b\u591a\u9762\u7684\u306b\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u304d\u308b\u6210\u5206\u3068\u3057\u3066\u3001\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u306e\u201c\u653b\u3081\u306e\u4fdd\u6e7f\uff08\u6574\u808c\uff09\u201d\u8aac\u660e\u306b\u76f4\u7d50\u3059\u308b\u3002
\r\n\r\n\u30103\u3011Pullar JM, Carr AC, Vissers MCM. The Roles of Vitamin C in Skin Health. Nutrients. 2017;9(8):866.<\/a><\/cite>
\r\n\r\nPMID: 28805671\u3000DOI: 10.3390\/nu9080866
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u30d3\u30bf\u30df\u30f3C\u306e\u30b3\u30e9\u30fc\u30b2\u30f3\u5408\u6210\u30fb\u6297\u9178\u5316\u30fb\u8272\u7d20\u6c88\u7740\u3078\u306e\u95a2\u4e0e\u3092\u7dcf\u8aac\u3068\u3057\u3066\u6574\u7406\u3002\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u306e\u3088\u3046\u306a\u30d3\u30bf\u30df\u30f3C\uff08\u304a\u3088\u3073\u8a98\u5c0e\u4f53\uff09\u914d\u5408\u5316\u7ca7\u6c34\u306e\u201c\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\uff0b\u304f\u3059\u307f\u5bfe\u7b56\u201d\u306e\u79d1\u5b66\u7684\u80cc\u666f\u3068\u306a\u308b\u3002
\r\n\r\n\u30104\u3011Bai X-D, Liu Y-C, Ge S-Y, Fei W-C. Clinical Trial of Salmon Nasal Cartilage-Derived Proteoglycans on Human Facial Antiaging: A Randomized, Double-Blind, Placebo-Controlled Study. J Cosmet Dermatol. 2025;24(7):e70218.<\/a><\/cite>
\r\n\r\nPMID: 40613544\u3000DOI: 10.1111\/jocd.70218
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u6442\u53d6\u306e\u4e8c\u91cd\u76f2\u691cRCT\u3067\u3001\u5f3e\u529b\u30fb\u6c34\u5206\u30fb\u3057\u308f\u7b49\u304c\u6539\u5584\u3002\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u3092\u201c\u808c\u30b3\u30f3\u30c7\u30a3\u30b7\u30e7\u30f3\u6539\u5584\u201d\u306e\u6839\u62e0\u3068\u306a\u308b\u3002
\r\n\r\n\u30105\u3011Rawlings AV, Harding CR. Moisturization and skin barrier function. Dermatol Ther. 2004;17 Suppl 1:43\u201348.<\/a><\/cite>
\r\n\r\nPMID: 14728698\u3000DOI: 10.1111\/j.1396-0296.2004.04s1005.x
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u89d2\u8cea\u5c64\u306e\u4fdd\u6e7f\u3068\u30d0\u30ea\u30a2\u6a5f\u80fd\u306e\u7dcf\u8aac\u3002NMF\uff08PCA\u7b49\uff09\u3084\u7d30\u80de\u9593\u8102\u8cea\u304c\u6c34\u5206\u4fdd\u6301\u306b\u91cd\u8981\u3067\u3001\u4fdd\u6e7f\u306f\u300c\u6c34\u3092\u4e0e\u3048\u308b\u300d\u3060\u3051\u3067\u306a\u304f\u4fdd\u6301\u3067\u304d\u308b\u89d2\u8cea\u74b0\u5883\u3092\u4f5c\u308b\u3053\u3068\u304c\u8981\u70b9\u3068\u6574\u7406\u3002\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u306e\u3088\u3046\u306a\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u5316\u7ca7\u6c34\u306e\u4fdd\u6e7f\u8a2d\u8a08\u306e\u6839\u62e0\u3002
\r\n\r\n\u30106\u3011Draelos ZD. The science behind skin care: Moisturizers. J Cosmet Dermatol. 2018;17(2):138\u2013144.<\/a><\/cite>
\r\n\r\nPMID: 29319217\u3000DOI: 10.1111\/jocd.12490
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u4fdd\u6e7f\u5264\uff08\u5316\u7ca7\u6c34\u301c\u4e73\u6db2\u30fb\u30af\u30ea\u30fc\u30e0\u542b\u3080\uff09\u306e\u79d1\u5b66\u3092\u6574\u7406\u3002\u30d2\u30e5\u30fc\u30e1\u30af\u30bf\u30f3\u30c8\uff08\u30b0\u30ea\u30bb\u30ea\u30f3\u7b49\uff09\uff0b\u30a8\u30e2\u30ea\u30a8\u30f3\u30c8\uff0b\u30aa\u30af\u30eb\u30fc\u30b7\u30d6\u306e\u5f79\u5272\u3001\u523a\u6fc0\u6027\u3001\u808c\u72b6\u614b\u306b\u5408\u308f\u305b\u305f\u9078\u629e\u304c\u91cd\u8981\u3067\u3001\u201c\u3055\u3089\u3063\u3068\u3067\u3082\u4fdd\u6e7f\u3067\u304d\u308b\u201d\u5316\u7ca7\u6c34\u3067\u3042\u308b\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u306e\u4fdd\u6e7f\u52b9\u679c\u306e\u6839\u62e0\u3002
\r\n\r\n\r\n\u30107\u3011Verdier-S\u00e9vrain S, Bont\u00e9 F. Skin hydration: a review on its molecular mechanisms. J Cosmet Dermatol. 2007;6(2):75\u201382.<\/a><\/cite>
\r\n\r\nPMID: 17524122\u3000DOI: 10.1111\/j.1473-2165.2007.00300.x
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u76ae\u819a\u306e\u3046\u308b\u304a\u3044\u306f\u89d2\u8cea\u69cb\u9020\u30fbNMF\u30fb\u8102\u8cea\u30fb\u6c34\u5206\u79fb\u52d5\u304c\u9023\u52d5\u3057\u3066\u7dad\u6301\u3055\u308c\u308b\u3068\u89e3\u8aac\u3002\u4e7e\u71e5\u3067\u843d\u5c51\u304c\u9032\u3080\u6a5f\u5e8f\u3084\u4fdd\u6e7f\u56e0\u5b50\u306e\u91cd\u8981\u6027\u3092\u6574\u7406\u3057\u3066\u304a\u308a\u3001\u300c\u6f64\u3046\u808c\u300d\uff1d\u89d2\u8cea\u306e\u4ed5\u7d44\u307f\u304b\u3089\u8aac\u660e\u3059\u308b\u969b\u306e\u57fa\u76e4\u6587\u732e\u3002
\r\n\r\n\u30108\u3011Wehr RF, Krochmal L. Considerations in selecting a moisturizer. Cutis. 1987;39(6):512\u2013515.<\/a><\/cite>
\r\n\r\nPMID: 3608578
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u4e7e\u71e5\uff08\u89d2\u8cea\u306e\u4e7e\u71e5\uff09\u306b\u5bfe\u3057\u3001\u30d2\u30e5\u30fc\u30e1\u30af\u30bf\u30f3\u30c8\uff0f\u30aa\u30af\u30eb\u30fc\u30b7\u30d6\uff0f\u30a8\u30e2\u30ea\u30a8\u30f3\u30c8\u306e\u5f79\u5272\u3067\u8a2d\u8a08\u30fb\u9078\u629e\u3059\u308b\u8003\u3048\u65b9\u3092\u6574\u7406\u3057\u3001\u6210\u5206\u6a5f\u80fd\u3068\u808c\u72b6\u614b\uff08\u4e7e\u71e5\u306e\u7a0b\u5ea6\uff09\u306b\u5fdc\u3058\u305f\u9078\u629e\u306e\u8981\u70b9\u3092\u63d0\u793a\u3002\u5316\u7ca7\u6c34\u3092\u300c\u4f55\u3092\u57fa\u6e96\u306b\u9078\u3076\u304b\u300d\u3092\u77ed\u304f\u533b\u5b66\u7684\u306b\u652f\u3048\u308b\u6839\u62e0\u3068\u306a\u308b\u3002\r\n\r\n<\/pre>\n\u8457\u8005\u30fb\u7de8\u96c6\u8005\u30fb\u6821\u6b63\u8005\u60c5\u5831<\/h2>\n<\/div>\n

\n\uff08\u7de8\u96c6\u30fb\u6821\u6b63\uff1a\u682a\u5f0f\u4f1a\u793e\u30c7\u30a3\u30fc\u30d7\u30a4\u30f3\u30d1\u30af\u30c8\u3000\u4ee3\u8868\u53d6\u7de0\u5f79\u3000\u5bcc\u672c\u5145\u662d\uff09<\/p>\n