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\uff2b\uff2f\uff2c\u30c9\u30af\u30bf\u30fc\u306e\u7684\u78ba\u306a\u4eba\u9078\u3068\u826f\u597d\u306a\u95a2\u4fc2\u4f5c\u308a\u306e\u30b3\u30c4<\/a><\/p>\n \u533b\u85ac\u54c1\u30de\u30fc\u30b1\u30c6\u30a3\u30f3\u30b0\u306b\u304a\u3051\u308b\u5e02\u5834\u30fb\u58f2\u4e0a\u4e88\u6e2c\u3068\u6226\u7565\u7b56\u5b9a<\/a><\/p>\n<\/div>\n<\/div>\n \u5f53\u793e\u30b9\u30bf\u30c3\u30d5\u306e\u672c\u696d\u306f\u3001\u533b\u5b66\u30fb\u85ac\u5b66\u95a2\u9023\u306e\u4e8b\u696d\u306e\u305f\u3081\u3001\u65e5\u3005\u3001\u533b\u5b66\u8ad6\u6587\u3084\u533b\u5b66\u4f1a\u306e\u767a\u8868\u306a\u3069\u306e\u6700\u65b0\u60c5\u5831\u306b\u89e6\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n \u305d\u3093\u306a\u4e2d\u3067\u3001\u300c\u3053\u308c\u306f\uff01\u300d\u3068\u3044\u3046\u3001\u307f\u306a\u3055\u307e\u306e\u5065\u5eb7\u3065\u304f\u308a\u306e\u3054\u53c2\u8003\u306b\u306a\u308b\u3088\u3046\u306a\u60c5\u5831\u3054\u7d39\u4ecb\u3057\u305f\u308a\u3001\u305d\u306e\u6642\u671f\u306b\u5408\u3063\u305f\u30b9\u30ad\u30f3\u30b1\u30a2\u3084\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u306e\u304a\u5f79\u7acb\u3061\u60c5\u5831\u3092\u30e1\u30fc\u30eb\u3067\u30b3\u30f3\u30d1\u30af\u30c8\u306b\u304a\u5c4a\u3051\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n \u305c\u3072\u3054\u767b\u9332\u3092\u304a\u5f85\u3061\u3057\u3066\u304a\u308a\u307e\u3059\u3002<\/p>\n
<\/a><\/p>\n
\n2\uff0e\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u306b\u914d\u5408\u3055\u308c\u3066\u3044\u308b\u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\u3068\u306f\uff1f<\/h2>\n
\n
\n
\n3\uff0e\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u306b\u914d\u5408\u3055\u308c\u3066\u3044\u308b\u4ed6\u306e\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u6210\u5206\u3068\u306f\uff1f<\/h2>\n
\n
\n4\uff0e\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u3092\u5b9f\u969b\u306b\u4f7f\u3063\u3066\u307f\u307e\u3057\u305f\uff01<\/h2>\n
<\/a><\/p>\n
\n5\uff0e\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u30a2\u30ab\u30c7\u30df\u30fc\u7de8\u96c6\u90e8\u30b3\u30e1\u30f3\u30c8<\/h2>\n
\uff1c\u53c2\u7167\u8ad6\u6587\uff1e<\/h2>\n
\r\n\u30101\u3011\u6e6f\u6d45\uff08\u5c0f\u5cf6\uff09\u660e\u5b50, \u6797\u7db8\u5b50, \u97d3\u7acb\u53cb, \u6e21\u8fba\u6587\u592a, \u5e73\u7af9\u6f64.\u03b3-\u30b0\u30eb\u30bf\u30df\u30eb\u30c8\u30e9\u30f3\u30b9\u30d7\u30c1\u30c0\u30fc\u30bc\uff08GGT\uff09\u963b\u5bb3\u5264\u306b\u3088\u308b\u30b3\u30e9\u30fc\u30b2\u30f3\u304a\u3088\u3073\u30a8\u30e9\u30b9\u30c1\u30f3\u7523\u751f\u80fd\u306e\u4ea2\u9032\u52b9\u679c\u3068\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0.\u65e5\u672c\u9999\u7ca7\u54c1\u5b66\u4f1a\u8a8c. Vol.36, No.2, 93\u2013100, 2012.<\/a><\/cite>
\r\n\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\u00ae\u306e\u57fa\u3068\u306a\u308b GGT\u963b\u5bb3\u4f5c\u7528 \u304c\u3001\u30d2\u30c8\u76ae\u819a\u7dda\u7dad\u82bd\u7d30\u80de\u306b\u304a\u3044\u3066\u30b3\u30e9\u30fc\u30b2\u30f3\u30fb\u30a8\u30e9\u30b9\u30c1\u30f3\u7523\u751f\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u57fa\u790e\u7814\u7a76\u3002\u771f\u76ae\u306e\u30cf\u30ea\u30fb\u5f3e\u529b\u7dad\u6301\u306b\u95a2\u4e0e\u3059\u308b\u5206\u5b50\u6a5f\u5e8f\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u304a\u308a\u3001\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u304c\u201c\u808c\u672c\u6765\u306e\u7f8e\u3057\u3055\u3092\u5e95\u4e0a\u3052\u3059\u308b\u5316\u7ca7\u6c34\u201d\u3068\u3057\u3066\u4f4d\u7f6e\u3065\u3051\u3089\u308c\u308b\u79d1\u5b66\u7684\u6839\u62e0\u3068\u306a\u308b\u91cd\u8981\u8ad6\u6587\u3002
\r\n\r\n\u30102\u3011Bissett DL, Oblong JE, Berge CA. Niacinamide: A B vitamin that improves aging facial skin appearance. Dermatol Surg. 2005;31(7 Pt 2):860\u2013865.<\/a><\/cite>
\r\n\r\nPMID: 16029679 DOI: 10.1111\/j.1524-4725.2005.31726
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u5916\u7528\u306b\u3088\u308a\u3001\u5c0f\u3058\u308f\u3001\u8272\u30e0\u30e9\u3001\u9ec4\u3050\u3059\u307f\u3001\u30d0\u30ea\u30a2\u6a5f\u80fd\uff08\u30bb\u30e9\u30df\u30c9\u7523\u751f\uff09 \u304c\u6539\u5584\u3057\u305f\u81e8\u5e8a\u7814\u7a76\u3002\u3046\u308b\u304a\u3044\u4fdd\u6301\u3068\u808c\u8cea\u6539\u5584\u306e\u4e21\u7acb\u304c\u793a\u3055\u308c\u3001\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u914d\u5408\u306e\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u306b\u3088\u308b\u6f64\u3044\u30a2\u30c3\u30d7\u3068\u900f\u660e\u611f\u30b1\u30a2\u306e\u88cf\u4ed8\u3051\u3068\u306a\u308b\u3002
\r\n\r\n\u30103\u3011Pullar JM, Carr AC, Vissers MCM. The roles of vitamin C in skin health. Nutrients. 2017;9(8):866.<\/a><\/cite>
\r\n\r\nPMID: 28805671 DOI: 10.3390\/nu9080866
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u30d3\u30bf\u30df\u30f3C\u306f\u30b3\u30e9\u30fc\u30b2\u30f3\u5408\u6210\u3001\u6297\u9178\u5316\u3001\u30e1\u30e9\u30cb\u30f3\u751f\u6210\u6291\u5236\u306b\u5fc5\u9808\u3067\u3042\u308a\u3001\u5916\u7528\u30d3\u30bf\u30df\u30f3C\u304a\u3088\u3073\u8a98\u5c0e\u4f53\u304c\u5149\u8001\u5316\u30fb\u4e7e\u71e5\u30fb\u304f\u3059\u307f\u5bfe\u7b56\u306b\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u3092\u7dcf\u8aac\u3002**\u30d3\u30bf\u30df\u30f3C\u8a98\u5c0e\u4f53\u3092\u542b\u3080\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u306e\u201c\u3046\u308b\u304a\u3044\uff0b\u660e\u308b\u3055\u30b1\u30a2\u201d**\u3092\u7406\u8ad6\u7684\u306b\u652f\u3048\u308b\u8ad6\u6587\u3002
\r\n\r\n\u30104\u3011Bai XD, Liu YC, Ge SY, Fei WC. Clinical trial of salmon nasal cartilage-derived proteoglycans on human facial anti-aging: a randomized, double-blind, placebo-controlled study. J Cosmet Dermatol. 2025;24(7):e70218.<\/a><\/cite>
\r\n\r\nPMID: 40613544 DOI: 10.1111\/jocd.70218
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u30b5\u30b1\u9f3b\u8edf\u9aa8\u7531\u6765\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u306e\u4e8c\u91cd\u76f2\u691cRCT\u3067\u3001\u808c\u6c34\u5206\u91cf\u30fb\u5f3e\u529b\u306e\u6539\u5584\u3068\u3001\u7c97\u3055\u30fb\u5c0f\u3058\u308f\u30fb\u8272\u30e0\u30e9\u306e\u4f4e\u4e0b\u3092\u78ba\u8a8d\u3002\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u306f\u9ad8\u3044\u4fdd\u6c34\u6027\u3092\u6709\u3057\u3001\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u306e\u201c\u6f64\u3044\u3092\u5e95\u4e0a\u3052\u3059\u308b\u5316\u7ca7\u6c34\u8a2d\u8a08\u201d\u306e\u79d1\u5b66\u7684\u88cf\u4ed8\u3051\u3068\u306a\u308b\u3002
\r\n\r\n\u30105\u3011Rawlings AV, Harding CR. Moisturization and skin barrier function. Dermatol Ther. 2004;17(Suppl 1):43\u201348.<\/a><\/cite>
\r\n\r\nPMID: 14728698 DOI: 10.1111\/j.1396-0296.2004.04s1005.x
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u89d2\u8cea\u5c64\u306e\u6c34\u5206\u4fdd\u6301\u306b\u306f NMF\uff08PCA \u306a\u3069\uff09\u3068\u7d30\u80de\u9593\u8102\u8cea \u304c\u4e0d\u53ef\u6b20\u3067\u3042\u308a\u3001\u4fdd\u6e7f\u306f\u300c\u6c34\u3092\u4e0e\u3048\u308b\u300d\u3060\u3051\u3067\u306a\u304f\u300c\u4fdd\u6301\u3067\u304d\u308b\u74b0\u5883\u3065\u304f\u308a\u300d\u304c\u91cd\u8981\u3068\u89e3\u8aac\u3002PCA-Na \u3092\u542b\u3080\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u306e\u9ad8\u4fdd\u6e7f\u8a2d\u8a08\u3092\u88cf\u4ed8\u3051\u308b\u57fa\u672c\u6587\u732e\u3002
\r\n\r\n\u30106\u3011Draelos ZD. The science behind skin care: Moisturizers. J Cosmet Dermatol. 2018;17(2):138\u2013144.<\/a><\/cite>
\r\n\r\nPMID: 29319217 DOI: 10.1111\/jocd.12490
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u5316\u7ca7\u6c34\u3092\u542b\u3080\u4fdd\u6e7f\u88fd\u54c1\u306e\u79d1\u5b66\u3092\u6574\u7406\u3057\u3001\u30d2\u30e5\u30fc\u30e1\u30af\u30bf\u30f3\u30c8\uff08\u30b0\u30ea\u30bb\u30ea\u30f3\u7b49\uff09\u30fb\u523a\u6fc0\u6027\u30fb\u808c\u72b6\u614b\u9069\u5408\u6027\u304c\u91cd\u8981\u3068\u8ad6\u3058\u308b\u3002\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u306e\u300c\u6bce\u65e5\u4f7f\u3048\u308b\u4f4e\u523a\u6fc0\u30fb\u9ad8\u4fdd\u6e7f\u5316\u7ca7\u6c34\u300d\u3068\u3044\u3046\u4f4d\u7f6e\u3065\u3051\u3092\u8aac\u660e\u3059\u308b\u6839\u62e0\u3068\u306a\u308b\u3002
\r\n\r\n\u30107\u3011Verdier-S\u00e9vrain S, Bont\u00e9 F. Skin hydration: a review on its molecular mechanisms. J Cosmet Dermatol. 2007;6(2):75\u201382.<\/a><\/cite>
\r\n\r\nPMID: 17524122 DOI: 10.1111\/j.1473-2165.2007.00300.x
\r\n\r\n\u65e5\u672c\u8a9e\u8981\u65e8\uff1a<\/strong>\u76ae\u819a\u306e\u3046\u308b\u304a\u3044\u306f\u89d2\u5c64\u69cb\u9020\u3001NMF\u3001\u8102\u8cea\u3001\u6c34\u5206\u79fb\u52d5\u304c\u9023\u52d5\u3057\u3066\u7dad\u6301\u3055\u308c\u308b\u3068\u89e3\u8aac\u3002\u4e7e\u71e5\u306b\u3088\u308b\u30ad\u30e1\u4e71\u308c\u30fb\u3054\u308f\u3064\u304d\u306e\u5206\u5b50\u6a5f\u5e8f\u3092\u6574\u7406\u3057\u3066\u304a\u308a\u3001\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u3067\u6f64\u3044\u3092\u88dc\u3044\u3001\u808c\u72b6\u614b\u3092\u6574\u3048\u308b\u30b1\u30a2\u306e\u7406\u8ad6\u7684\u80cc\u666f\u3068\u3057\u3066\u6700\u9069\u306a\u7dcf\u8aac\u3002\r\n\r\n<\/pre>\n\u8457\u8005\u30fb\u7de8\u96c6\u8005\u30fb\u6821\u6b63\u8005\u60c5\u5831<\/h2>\n<\/div>\n

\n\uff08\u7de8\u96c6\u30fb\u6821\u6b63\uff1a\u682a\u5f0f\u4f1a\u793e\u30c7\u30a3\u30fc\u30d7\u30a4\u30f3\u30d1\u30af\u30c8\u3000\u4ee3\u8868\u53d6\u7de0\u5f79\u3000\u5bcc\u672c\u5145\u662d\uff09<\/p>\n