{"id":76075,"date":"2025-11-20T23:07:27","date_gmt":"2025-11-20T14:07:27","guid":{"rendered":"https:\/\/www.nahls.co.jp\/eijingukea\/?p=76075"},"modified":"2025-11-20T23:07:27","modified_gmt":"2025-11-20T14:07:27","slug":"eijingukea-50dai-keshousui-use","status":"publish","type":"post","link":"https:\/\/www.nahls.co.jp\/eijingukea\/cosmetics\/eijingukea-50dai-keshousui-use\/","title":{"rendered":"50\u4ee3\u306e\u5316\u7ca7\u6c34\u306e\u6b63\u3057\u3044\u4f7f\u3044\u65b9\u3092\u30a8\u30d3\u30c7\u30f3\u30b9\u3067\u5b66\u3076\uff5c\u4fdd\u6e7f\u30fb\u53ce\u6582\u30fb\u62ed\u304d\u53d6\u308a\u306e\u6ce8\u610f\u70b9"},"content":{"rendered":"<p>50\u4ee3\u306b\u306a\u308b\u3068\u3001\u808c\u306e\u6c34\u5206\u4fdd\u6301\u529b\u30fb\u30cf\u30ea\u30fb\u5f3e\u529b\u304c\u6025\u6fc0\u306b\u4f4e\u4e0b\u3057\u307e\u3059\u3002<\/p>\n<p>\u305d\u306e\u305f\u3081\u3001\u5316\u7ca7\u6c34\u306e\u300c\u9078\u3073\u65b9\u300d\u3060\u3051\u3067\u306a\u304f\u3001\u300c\u4f7f\u3044\u65b9\u300d\u3053\u305d\u304c\u7f8e\u808c\u3092\u5de6\u53f3\u3059\u308b\u91cd\u8981\u306a\u30dd\u30a4\u30f3\u30c8\u3067\u3059\u3002<\/p>\n<p>\u82e5\u3044\u9803\u306e\u3088\u3046\u306b\u30b3\u30c3\u30c8\u30f3\u3067\u30d1\u30c3\u30c6\u30a3\u30f3\u30b0\u3057\u305f\u308a\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u5165\u308a\u306e\u53ce\u6582\u5316\u7ca7\u6c34\u3092\u4f7f\u3046\u3068\u3001\u304b\u3048\u3063\u3066\u4e7e\u71e5\u3084\u523a\u6fc0\u3092\u62db\u304f\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u672c\u8a18\u4e8b\u3067\u306f\u300150\u4ee3\u306e\u808c\u306b\u9069\u3057\u305f\u5316\u7ca7\u6c34\u306e\u6b63\u3057\u3044\u4f7f\u3044\u65b9\u3092\u3001\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u306e\u89b3\u70b9\u304b\u3089\u79d1\u5b66\u7684\u6839\u62e0\u3092\u4ea4\u3048\u3066\u7d39\u4ecb\u3002<\/p>\n<p>\u3055\u3089\u306b\u3001\u62ed\u304d\u53d6\u308a\u5316\u7ca7\u6c34\u3084\u53ce\u6582\u5316\u7ca7\u6c34\u306e\u6ce8\u610f\u70b9\u3001\u7f8e\u5bb9\u6db2\u30fb\u30af\u30ea\u30fc\u30e0\u3068\u306e\u91cd\u306d\u65b9\u3001\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u3044\u305f\u4fdd\u6e7f\u6cd5\u307e\u3067\u5c02\u9580\u5bb6\u76e3\u4fee\u306e\u4e0b\u306b\u8a73\u3057\u304f\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n<p>\u307e\u305f\u300150\u4ee3\u306b\u304a\u3059\u3059\u3081\u306e\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u5316\u7ca7\u6c34\u300c\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u300d\u306e\u4f7f\u3044\u65b9\u3082\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<div class=\"doctor_kansyu_area\">\n<div class=\"ishi_flexbox\">\n<div class=\"ishi_img_box\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-54916 size-thumbnail\" src=\"\/eijingukea\/wp-content\/uploads\/2019\/02\/f31a02784b8c6537895804d72a2ee1ce-150x150.jpg\" alt=\"\u6751\u4e0a\u6e05\u7f8e\" width=\"150\" height=\"150\" \/><\/div>\n<div class=\"ishi_text_box\">\n<p class=\"kanshu_ishi\">\u3053\u306e\u8a18\u4e8b\u306e\u76e3\u4fee\u8005<\/p>\n<p class=\"clinic_name\"><a href=\"https:\/\/www.nahls.co.jp\/\" target=\"_blank\" rel=\"noopener\">\u30ca\u30fc\u30eb\u30b9\u30b3\u30e0<\/a><\/p>\n<p class=\"name\">\u5e97\u9577<\/p>\n<p class=\"ishi_name\"><a href=\"https:\/\/www.nahls.co.jp\/eijingukea\/doctor-list\/murakami-kiyomi\/\" target=\"_blank\" rel=\"noopener\">\u30ca\u30fc\u30eb\u30b9\u30b3\u30e0\u5e97\u9577\u3000\u6751\u4e0a\u6e05\u7f8e<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<h2 class=\"md2\">1.\u306a\u305c50\u4ee3\u306f\u5316\u7ca7\u6c34\u306e\u4f7f\u3044\u65b9\u304c\u5927\u5207\u306a\u306e\u304b<\/h2>\n<p>50\u4ee3\u306e\u808c\u306f\u3001\u5358\u306a\u308b\u4e7e\u71e5\u3067\u306f\u306a\u304f\u3001\u52a0\u9f62\u3084\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u306e\u5909\u5316\u306b\u3088\u308b\u69cb\u9020\u7684\u306a\u5909\u5316\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n<p>\u305d\u306e\u305f\u3081\u3001\u3069\u3093\u306a\u306b\u9ad8\u6a5f\u80fd\u306a\u5316\u7ca7\u6c34\u3092\u9078\u3093\u3067\u3082\u3001\u4f7f\u3044\u65b9\u304c\u8aa4\u3063\u3066\u3044\u308c\u3070\u5341\u5206\u306a\u52b9\u679c\u3092\u767a\u63ee\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n<p>\u3053\u3053\u3067\u306f\u300150\u4ee3\u7279\u6709\u306e\u808c\u5909\u5316\u3068\u5316\u7ca7\u6c34\u306e\u4f7f\u3044\u65b9\u304c\u91cd\u8981\u306a\u7406\u7531\u3092\u3001\u79d1\u5b66\u7684\u6839\u62e0\uff08\u30a8\u30d3\u30c7\u30f3\u30b9\uff09\u306b\u57fa\u3065\u3044\u3066\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n<h3>1\uff09 \u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u3068\u76ae\u819a\u69cb\u9020\u306e\u5909\u5316<\/h3>\n<p>50\u4ee3\u3067\u306f\u3001\u5973\u6027\u30db\u30eb\u30e2\u30f3\u306e\u3072\u3068\u3064\u3067\u3042\u308b\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u304c\u6025\u6e1b\u3057\u3001\u771f\u76ae\u306e\u30b3\u30e9\u30fc\u30b2\u30f3\u3084\u30a8\u30e9\u30b9\u30c1\u30f3\u304c\u6e1b\u5c11\u3057\u307e\u3059\u3002<\/p>\n<p>\u81e8\u5e8a\u7814\u7a76\u306b\u3088\u308b\u3068\u3001\u9589\u7d4c\u5f8c\u306e\u5973\u6027\u3067\u306f\u30b3\u30e9\u30fc\u30b2\u30f3\u91cf\u304c\u7d0430\uff05\u4f4e\u4e0b\u3057\u3001\u76ae\u819a\u306e\u539a\u307f\u30fb\u5f3e\u529b\u30fb\u6c34\u5206\u4fdd\u6301\u80fd\u304c\u9855\u8457\u306b\u6e1b\u5c11\u3057\u307e\u3059\uff08Farage et al., 2022; Gonz\u00e1lez-Garc\u00eda et al., 2023\uff09\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u3053\u306e\u5909\u5316\u306b\u3088\u308a\u3001\u808c\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u304c\u5f31\u307e\u308a\u3001\u5916\u7684\u523a\u6fc0\u306b\u654f\u611f\u306b\u306a\u308a\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u6469\u64e6\u3092\u907f\u3051\u305f\u512a\u3057\u3044\u5857\u5e03\u6cd5\u304c\u808c\u3092\u5b88\u308b\u9375\u3067\u3059\u3002<\/p>\n<p>\u3053\u306e\u3088\u3046\u306b50\u4ee3\u3067\u306f\u300c\u4f55\u3092\u4f7f\u3046\u304b\u300d\u306b\u52a0\u3048\u3066\u300c\u3069\u3046\u4f7f\u3046\u304b\u300d\u3082\u91cd\u8981\u3067\u3059\u3002<\/p>\n<h3>2\uff09 \u6d78\u900f\uff08\u89d2\u8cea\u5c64\u307e\u3067\uff09\u306e\u9045\u308c\u3068\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u4f4e\u4e0b<\/h3>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-76083 size-medium\" src=\"\/eijingukea\/wp-content\/uploads\/2025\/11\/20e4381bcbd5b084bab17fb99d355fad-300x300.png\" alt=\"\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u306e\u30a4\u30e1\u30fc\u30b8\" width=\"300\" height=\"300\" \/><\/p>\n<p>\u82e5\u3044\u9803\u306f\u7d0428\u65e5\u5468\u671f\u3067\u884c\u308f\u308c\u3066\u3044\u305f\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u304c\u300150\u4ee3\u3067\u306f40\u65e5\uff5e60\u65e5\u7a0b\u5ea6\u306b\u307e\u3067\u9045\u5ef6\u3057\u307e\u3059\u3002<\/p>\n<p>\u305d\u306e\u7d50\u679c\u3001\u53e4\u3044\u89d2\u8cea\u304c\u808c\u8868\u9762\u306b\u6b8b\u308a\u3001\u5316\u7ca7\u6c34\u306e\u4fdd\u6e7f\u6210\u5206\u304c\u89d2\u8cea\u5c64\u307e\u3067\u5c4a\u304d\u306b\u304f\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u307e\u305f\u3001\u89d2\u8cea\u5c64\u306e\u30bb\u30e9\u30df\u30c9\u3084\u5929\u7136\u4fdd\u6e7f\u56e0\u5b50\uff08NMF\uff09\u3082\u6e1b\u5c11\u3057\u3001\u6c34\u5206\u306e\u901a\u308a\u9053\u304c\u72ed\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>Spada et al. (2018\uff09\u306e\u7814\u7a76\u3067\u306f\u3001\u30bb\u30e9\u30df\u30c9\u542b\u6709\u4fdd\u6e7f\u5264\u306e\u5916\u7528\u306b\u3088\u3063\u3066\u89d2\u5c64\u306e\u6c34\u5206\u91cf\u304c\u6709\u610f\u306b\u5897\u52a0\u3057\u3001TEWL\uff08\u7d4c\u8868\u76ae\u6c34\u5206\u84b8\u6563\u91cf\uff09\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3053\u308c\u306f\u3001\u89d2\u8cea\u5c64\u306b\u6c34\u5206\u3092\u3057\u3063\u304b\u308a\u4fdd\u6301\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u3086\u3063\u304f\u308a\u91cd\u306d\u3065\u3051\u3057\u3066\u6d78\u900f\uff08\u89d2\u8cea\u5c64\u307e\u3067\uff09\u3092\u4fc3\u3059\u4f7f\u3044\u65b9\u304c\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u3092\u88cf\u3065\u3051\u3066\u3044\u307e\u3059\u3002<\/p>\n<h3>3\uff09 \u5857\u5e03\u6cd5\u306e\u9055\u3044\u3067\u3046\u308b\u304a\u3044\u6301\u7d9a\u6642\u9593\u304c\u5909\u308f\u308b\u7406\u7531<\/h3>\n<p>\u540c\u3058\u5316\u7ca7\u6c34\u3067\u3082\u3001\u5857\u5e03\u6cd5\u306b\u3088\u3063\u3066\u4fdd\u6e7f\u52b9\u679c\u306e\u6301\u7d9a\u6642\u9593\u306b\u5dee\u304c\u51fa\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>Arce et al. (2019\uff09\u306e\u7814\u7a76\u3067\u306f\u3001\u540c\u4e00\u6210\u5206\u3092\u300c\u4e00\u56de\u5857\u5e03\u300d\u3068\u300c\u91cd\u306d\u5857\u308a\u300d\u3067\u6bd4\u8f03\u3057\u305f\u7d50\u679c\u3001\u91cd\u306d\u5857\u308a\u304c\u6210\u5206\u306e\u900f\u904e\u3084\u76ae\u819a\u6ede\u7559\u91cf\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u3053\u306e\u3053\u3068\u304b\u3089\u3001\u5316\u7ca7\u6c34\u30922\u301c3\u56de\u306b\u5206\u3051\u3066\u4e01\u5be7\u306b\u91cd\u306d\u308b\u3053\u3068\u3067\u3001\u89d2\u8cea\u5c64\u5185\u306b\u6c34\u5206\u304c\u3088\u308a\u5747\u4e00\u306b\u884c\u304d\u6e21\u308a\u3001\u3046\u308b\u304a\u3044\u306e\u6301\u7d9a\u6642\u9593\u3092\u9ad8\u3081\u3089\u308c\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<p>\u3055\u3089\u306b\u3001\u624b\u306e\u3072\u3089\u3067\u6e29\u3081\u3066\u304b\u3089\u62bc\u3057\u8fbc\u3080\u300c\u30cf\u30f3\u30c9\u30d7\u30ec\u30b9\u6cd5\u300d\u306f\u8840\u884c\u3092\u4fc3\u3057\u3001\u6d78\u900f\uff08\u89d2\u8cea\u5c64\u307e\u3067\uff09\u3092\u52a9\u3051\u308b\u52b9\u679c\u3082\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/p>\n<p>\u3064\u307e\u308a\u3001\u6b63\u3057\u3044\u5857\u5e03\u6cd5\u306f\u5358\u306a\u308b\u30de\u30ca\u30fc\u3067\u306f\u306a\u304f\u3001\u808c\u79d1\u5b66\u306b\u57fa\u3065\u3044\u305f\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u306e\u57fa\u672c\u6280\u8853\u306a\u306e\u3067\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<table>\n<tbody>\n<tr>\n<td width=\"566\"><strong>\uff1c\u76e3\u4fee\u8005\u30b3\u30e1\u30f3\u30c8\uff1e<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-74866\" src=\"\/eijingukea\/wp-content\/uploads\/2025\/09\/kiyomi_murakami-1.png\" alt=\"\u6751\u4e0a\u6e05\u7f8e\" width=\"100\" height=\"100\" \/><\/p>\n<p>50\u4ee3\u306e\u5316\u7ca7\u6c34\u306f\u300c\u9078\u3073\u65b9\u300d\u3060\u3051\u3067\u306a\u304f\u300c\u4f7f\u3044\u65b9\u300d\u304c\u7f8e\u808c\u3092\u5de6\u53f3\u3057\u307e\u3059\u3002<\/p>\n<p>\u3084\u3055\u3057\u304f\u91cd\u306d\u3066\u3001\u808c\u306b\u5fc5\u8981\u306a\u6c34\u5206\u3068\u6210\u5206\u3092\u4e01\u5be7\u306b\u5c4a\u3051\u308b\u610f\u8b58\u304c\u3001\u771f\u306e\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u306e\u7b2c\u4e00\u6b69\u3067\u3059\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p><strong>\uff1c\u53c2\u7167\u8ad6\u6587\uff1e<\/strong><\/p>\n<p>1.Farage MA, et al. <em>Updated Perspectives on the Role of Estrogens in Skin Aging.<\/em> <em>Clin Cosmet Investig Dermatol.<\/em> 2022; 15:2111\u20132124. doi:10.2147\/CCID.S387833<\/p>\n<p>URL: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36381976\/\" target=\"_blank\" rel=\"noopener\" data-nodal=\"\">https:\/\/pubmed.ncbi.nlm.nih.gov\/36381976\/<\/a><\/p>\n<p>\u8981\u65e8\uff08\u65e5\u672c\u8a9e\uff09\uff1a\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306e\u4f4e\u4e0b\u306f\u7dda\u7dad\u82bd\u7d30\u80de\u306e\u30b3\u30e9\u30fc\u30b2\u30f3\u7523\u751f\u3084\u8102\u8cea\u30d0\u30ea\u30a2\u5f62\u6210\u3092\u6291\u5236\u3057\u3001\u4e7e\u71e5\u30fb\u5f1b\u7de9\u30fb\u3057\u308f\u3092\u62db\u304f\u3002\u9589\u7d4c\u5f8c\u5973\u6027\u306e\u808c\u8001\u5316\u306b\u304a\u3051\u308b\u751f\u7269\u5b66\u7684\u5909\u5316\u3092\u660e\u78ba\u5316\u3002<\/p>\n<p>2.Gonz\u00e1lez-Garc\u00eda R, et al. <em>A Narrative Review of Skin Quality Changes, Their Aesthetic Impact and Treatment Options.<\/em> <em>J Clin Med.<\/em> 2023; 12(18\uff09:5896. doi:10.3390\/jcm12185896<\/p>\n<p>URL: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37761630\/\" target=\"_blank\" rel=\"noopener\" data-nodal=\"\">https:\/\/pubmed.ncbi.nlm.nih.gov\/37761630\/<\/a><\/p>\n<p>\u8981\u65e8\uff08\u65e5\u672c\u8a9e\uff09\uff1a\u9589\u7d4c\u524d\u5f8c\u306e\u5973\u6027\u3067\u771f\u76ae\u30b3\u30e9\u30fc\u30b2\u30f3\u6e1b\u5c11\u30fb\u5f3e\u529b\u4f4e\u4e0b\u304c\u9855\u8457\u3067\u3001\u4fdd\u6e7f\u304a\u3088\u3073\u6297\u9178\u5316\u30b1\u30a2\u304c\u4e0d\u53ef\u6b20\u3067\u3042\u308b\u3068\u7d50\u8ad6\u3065\u3051\u305f\u7dcf\u8aac\u3002<\/p>\n<p>3.Spada F, et al. <em>Skin hydration is significantly increased by a ceramide-containing cream and correlates with a reduction in TEWL.<\/em> <em>Int J Cosmet Sci.<\/em> 2018; 40(2\uff09:204-213. doi:10.1111\/ics.12463<\/p>\n<p>URL: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6197824\/?utm_source=chatgpt.com\" target=\"_blank\" rel=\"noopener\" data-nodal=\"\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6197824\/<\/a><\/p>\n<p>\u8981\u65e8\uff08\u65e5\u672c\u8a9e\uff09\uff1a\u30bb\u30e9\u30df\u30c9\u542b\u6709\u30af\u30ea\u30fc\u30e0\u306e\u5358\u56de\u5857\u5e03\u306b\u3088\u308a\u89d2\u8cea\u5c64\u6c34\u5206\u91cf\u304c\u5897\u52a0\u3057\u3001TEWL\u304c\u6709\u610f\u306b\u4f4e\u4e0b\u3002\u5916\u7528\u306b\u3088\u308b\u89d2\u5c64\u30d0\u30ea\u30a2\u6a5f\u80fd\u56de\u5fa9\u3092\u78ba\u8a8d\u3002<\/p>\n<p>4.Arce FV Jr, Asano N, Yamashita K, et al. <em>Effect of layered application on the skin permeation of a cosmetic active component, rhododendrol.<\/em> <em>J Toxicol Sci.<\/em> 2019; 44(1\uff09:1-11. doi:10.2131\/jts.44.1<\/p>\n<p>URL: <a href=\"https:\/\/www.jstage.jst.go.jp\/article\/jts\/44\/1\/44_1\/_html\/-char\/en?utm_source=chatgpt.com\" target=\"_blank\" rel=\"noopener\" data-nodal=\"\">https:\/\/www.jstage.jst.go.jp\/article\/jts\/44\/1\/44_1\/_html\/-char\/en<\/a><\/p>\n<p>\u8981\u65e8\uff08\u65e5\u672c\u8a9e\uff09\uff1a\u540c\u6210\u5206\u3092\u300c\u4e00\u56de\u5857\u5e03\u300d\u3068\u300c\u91cd\u306d\u5857\u5e03\u300d\u3067\u6bd4\u8f03\u3057\u3001\u900f\u904e\u91cf\u306e\u5909\u5316\u3092\u78ba\u8a8d\u3002\u5857\u5e03\u91cf\u30fb\u56de\u6570\u30fb\u9593\u9694\u304c\u76ae\u819a\u5185\u6d78\u900f\u3084\u6ede\u7559\u306b\u5f71\u97ff\u3059\u308b\u3053\u3068\u3092\u5b9f\u8a3c\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>&lt;\u53c2\u8003\u8a18\u4e8b\uff1e<\/p>\n<p><a href=\"https:\/\/www.nahls.co.jp\/eijingukea\/cosmetics\/keshousui\/3-2\/\" target=\"_blank\" rel=\"noopener\" data-nodal=\"\">\u5316\u7ca7\u6c34\u306e\u6b63\u3057\u3044\u4f7f\u3044\u65b9\u3068\u3064\u3051\u65b9\u3067\u7f8e\u808c\u306b\uff01\u4e0a\u624b\u306a\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2<\/a><\/p>\n<p><a href=\"https:\/\/www.nahls.co.jp\/eijingukea\/cosmetics\/eijingukea-50dai-keshousui-select\/\" target=\"_blank\" rel=\"noopener\" data-nodal=\"\">50\u4ee3\u306e\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u5316\u7ca7\u6c34\u306e\u9078\u3073\u65b9\uff5c\u4fdd\u6e7f\u529b\u30fb\u30cf\u30ea\u3092\u53d6\u308a\u623b\u3059\u30dd\u30a4\u30f3\u30c8\u3092\u5fb9\u5e95\u89e3\u8aac<\/a><\/p>\n<p><a href=\"https:\/\/www.nahls.co.jp\/eijingukea\/cosmetics\/eijingukea-cosme\/50dai-keshousui\/\" target=\"_blank\" rel=\"noopener\" data-nodal=\"\">50\u4ee3\u306b\u304a\u3059\u3059\u3081\u306e\u52b9\u679c\u304c\u3042\u308b\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u5316\u7ca7\u6c3420\u9078\u4e00\u6319\u7d39\u4ecb<\/a><\/p>\n<p><a href=\"https:\/\/www.nahls.co.jp\/eijingukea\/cosmetics\/eijingukea-cosme\/50dai-2\/\" target=\"_blank\" rel=\"noopener\" data-nodal=\"\">50\u4ee3\u306e\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u5316\u7ca7\u54c1\u306e\u9078\u3073\u65b9\u3068\u5927\u5207\u306a7\u3064\u306e\u771f\u5b9f\uff01<\/a><\/p>\n<h2 class=\"md2\">2.50\u4ee3\u306b\u6700\u9069\u306a\u5316\u7ca7\u6c34\u306e\u4f7f\u3044\u65b9\u306e\u57fa\u672c\u30b9\u30c6\u30c3\u30d7<\/h2>\n<p>50\u4ee3\u306e\u808c\u306f\u3001\u6c34\u5206\u3092\u4e0e\u3048\u308b\u3060\u3051\u3067\u306f\u3046\u308b\u304a\u3044\u3092\u4fdd\u3066\u307e\u305b\u3093\u3002<\/p>\n<p>\u89d2\u8cea\u5c64\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u3001\u6c34\u5206\u3092\u84c4\u3048\u308b\u529b\u305d\u306e\u3082\u306e\u304c\u8870\u3048\u3066\u3044\u308b\u305f\u3081\u3001\u300c\u5857\u308a\u65b9\u300d\u3084\u300c\u9806\u756a\u300d\u304c\u7f8e\u808c\u306e\u9375\u3092\u63e1\u308a\u307e\u3059\u3002<\/p>\n<p>\u3053\u3053\u3067\u306f\u3001\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u3044\u305f5\u3064\u306e\u30b9\u30c6\u30c3\u30d7\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n<h3>1\uff09 \u624b\u306e\u3072\u3089\u3067\u6e29\u3081\u3066\u30cf\u30f3\u30c9\u30d7\u30ec\u30b9\uff08\u53e9\u304b\u306a\u3044\uff09<\/h3>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-76084 size-medium\" src=\"\/eijingukea\/wp-content\/uploads\/2025\/11\/warming_lotion_in_hands-300x200.jpg\" alt=\"\u624b\u3067\u5316\u7ca7\u6c34\u3092\u6e29\u3081\u308b\u69d8\u5b50\" width=\"300\" height=\"200\" \/><\/p>\n<p>50\u4ee3\u306e\u808c\u306f\u8840\u884c\u304c\u6ede\u308a\u3084\u3059\u3044\u305f\u3081\u3001\u6d78\u900f\uff08\u89d2\u8cea\u5c64\u307e\u3067\uff09\u306b\u6642\u9593\u304c\u304b\u304b\u308b\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u30b3\u30c3\u30c8\u30f3\u3067\u5f37\u304f\u53e9\u304f\u3068\u6469\u64e6\u3067\u708e\u75c7\u3092\u8d77\u3053\u3057\u3001\u30d0\u30ea\u30a2\u3092\u50b7\u3064\u3051\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u305d\u306e\u305f\u3081\u3001\u5316\u7ca7\u6c34\u3092\u624b\u306e\u3072\u3089\u3067\u4eba\u808c\u306b\u6e29\u3081\u3001\u5305\u307f\u8fbc\u3080\u3088\u3046\u306b\u62bc\u3057\u5f53\u3066\u308b\u300c\u30cf\u30f3\u30c9\u30d7\u30ec\u30b9\u300d\u304c\u7406\u60f3\u7684\u3067\u3059\u3002<\/p>\n<p>\u3053\u306e\u65b9\u6cd5\u306f\u808c\u8868\u9762\u306e\u6e29\u5ea6\u3092\u4e0a\u3052\u3066\u8840\u884c\u3092\u4fc3\u3057\u3001\u89d2\u5c64\u5185\u3078\u306e\u6d78\u900f\u3092\u52a9\u3051\u307e\u3059\u3002<\/p>\n<p>\u4e00\u5ea6\u306b\u591a\u91cf\u3092\u5857\u308b\u3088\u308a\u3082\u3001\u3084\u3055\u3057\u304f\u62bc\u3057\u8fbc\u3080\u3088\u3046\u306b\u5c11\u3057\u305a\u3064\u91cd\u306d\u308b\u306e\u304c\u30dd\u30a4\u30f3\u30c8\u3067\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\uff1c\u53c2\u8003\u8a18\u4e8b\uff1e<\/p>\n<p><a href=\"https:\/\/www.nahls.co.jp\/eijingukea\/cosmetics\/keshousui\/handpress\/\" target=\"_blank\" rel=\"noopener\" data-nodal=\"\">\u5316\u7ca7\u6c34\u306f\u30cf\u30f3\u30c9\u30d7\u30ec\u30b9\u3067\u6d78\u900f\u529b\u3084\u4fdd\u6e7f\u52b9\u679c\u304c\u9ad8\u307e\u308b\u3063\u3066\u672c\u5f53\uff1f<\/a><\/p>\n<p><a href=\"https:\/\/www.nahls.co.jp\/eijingukea\/cosmetics\/keshousui\/patting\/\" target=\"_blank\" rel=\"noopener\" data-nodal=\"\">\u5316\u7ca7\u6c34\u306e\u30d1\u30c3\u30c6\u30a3\u30f3\u30b0\u306f\u3001\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u306b\u3068\u3063\u3066\u826f\u3044\u3064\u3051\u65b9\uff1f<\/a><\/p>\n<h3>2\uff09 2\u301c3\u56de\u306e\u91cd\u306d\u3065\u3051\u3067\u89d2\u8cea\u5c64\u3092\u6e80\u305f\u3059<\/h3>\n<p>\u4e7e\u71e5\u3057\u305f\u89d2\u8cea\u5c64\u306f\u3001\u4e00\u5ea6\u306b\u5927\u91cf\u306e\u5316\u7ca7\u6c34\u3092\u4e0e\u3048\u3066\u3082\u5438\u53ce\u3057\u304d\u308c\u307e\u305b\u3093\u3002<\/p>\n<p>\u305d\u3053\u3067\u6709\u52b9\u306a\u306e\u304c2\u301c3\u56de\u306b\u5206\u3051\u3066\u306e\u91cd\u306d\u3065\u3051\u3067\u3059\u3002<\/p>\n<p>Spada et al. (2018\uff09\u306e\u7814\u7a76\u3067\u306f\u3001\u30bb\u30e9\u30df\u30c9\u542b\u6709\u4fdd\u6e7f\u5264\u306e\u5916\u7528\u306b\u3088\u308a\u89d2\u5c64\u6c34\u5206\u91cf\u304c\u6709\u610f\u306b\u5897\u52a0\u3057\u3001TEWL\uff08\u7d4c\u8868\u76ae\u6c34\u5206\u84b8\u6563\u91cf\uff09\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u3064\u307e\u308a\u3001\u91cd\u306d\u4ed8\u3051\u3067\u808c\u306e\u4fdd\u6e7f\u529b\u304c\u9ad8\u307e\u3063\u305f\u306e\u3067\u3059\u3002<\/p>\n<p>\u307e\u305f\u3001Arce et al. (2019\uff09\u306f\u300c\u5857\u5e03\u56de\u6570\u3084\u9593\u9694\u304c\u6210\u5206\u306e\u6d78\u900f\u30fb\u6ede\u7559\u306b\u5f71\u97ff\u3059\u308b\u300d\u3068\u6307\u6458\u3057\u3066\u304a\u308a\u3001\u91cd\u306d\u3065\u3051\u304c\u89d2\u8cea\u5c64\u306e\u6c34\u5206\u4fdd\u6301\u3068\u6301\u7d9a\u7684\u3046\u308b\u304a\u3044\u306b\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u3092\u88cf\u3065\u3051\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>1\u56de\u76ee\u3067\u6c34\u5206\u3068\u4fdd\u6e7f\u6210\u5206\u3092\u4e0e\u3048\u30012\u56de\u76ee\u4ee5\u964d\u3067\u4fdd\u6e7f\u6210\u5206\u3092\u808c\u306b\u6d78\u900f\u3055\u305b\u308b\u610f\u8b58\u3092\u6301\u3061\u307e\u3057\u3087\u3046\u3002<\/p>\n<h3>3\uff09 \u9996\u30fb\u30d5\u30a7\u30a4\u30b9\u30e9\u30a4\u30f3\u30fb\u30c7\u30b3\u30eb\u30c6\u307e\u3067\u5fd8\u308c\u305a\u306b<\/h3>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-76085 size-medium\" src=\"\/eijingukea\/wp-content\/uploads\/2025\/11\/decorte_cropped-300x200.jpg\" alt=\"\u5973\u6027\u306e\u30c7\u30b3\u30eb\u30c6\" width=\"300\" height=\"200\" \/><\/p>\n<p>50\u4ee3\u3067\u306f\u3001\u9854\u3060\u3051\u3067\u306a\u304f\u9996\u3084\u30d5\u30a7\u30a4\u30b9\u30e9\u30a4\u30f3\u306b\u3082\u4e7e\u71e5\u30fb\u305f\u308b\u307f\u306e\u30b5\u30a4\u30f3\u304c\u73fe\u308c\u307e\u3059\u3002<\/p>\n<p>\u76ae\u819a\u306e\u539a\u307f\u304c\u8584\u304f\u76ae\u8102\u817a\u3082\u5c11\u306a\u3044\u9996\u5468\u308a\u306f\u7279\u306b\u4e7e\u71e5\u3057\u3084\u3059\u3044\u305f\u3081\u3001\u9854\u3068\u540c\u3058\u5316\u7ca7\u6c34\u3092\u4e0b\u65b9\u5411\u306b\u6d41\u3059\u3088\u3046\u306b\u5857\u5e03\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u8efd\u304f\u624b\u306e\u3072\u3089\u3067\u5305\u307f\u3001\u6469\u64e6\u3092\u907f\u3051\u306a\u304c\u3089\u4e01\u5be7\u306b\u30b1\u30a2\u3057\u307e\u3057\u3087\u3046\u3002<\/p>\n<p>\u6bce\u65e5\u306e\u7a4d\u307f\u91cd\u306d\u304c\u3001\u5e74\u9f62\u306e\u51fa\u3084\u3059\u3044\u9996\u5143\u306e\u30cf\u30ea\u7dad\u6301\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\uff1c\u53c2\u8003\u8a18\u4e8b\uff1e<\/p>\n<p><a href=\"https:\/\/www.nahls.co.jp\/eijingukea\/nayami\/d\/dekorute-kea\/\" target=\"_blank\" rel=\"noopener\" data-nodal=\"\">\u30c7\u30b3\u30eb\u30c6\u306e\u30b1\u30a2\u306a\u3089\u52b9\u679c\u7684\u306a\u5316\u7ca7\u54c1\u3067\u9b45\u305b\u308b\u7d20\u808c\u3078\u5c0e\u304f<\/a><\/p>\n<h3>4\uff09 \u5316\u7ca7\u6c34\u306e\u5f8c\u306f\u7f8e\u5bb9\u6db2\u3082\u4f7f\u3046<\/h3>\n<p>\u5316\u7ca7\u6c34\u306f\u300c\u3046\u308b\u304a\u3044\u306e\u571f\u53f0\u300d\u3092\u6574\u3048\u308b\u30b9\u30c6\u30c3\u30d7\u3067\u3059\u3002<\/p>\n<p>\u3057\u304b\u3057\u300150\u4ee3\u306e\u808c\u3067\u306f\u305d\u308c\u3060\u3051\u3067\u306f\u4e0d\u5341\u5206\u3067\u3001\u7f8e\u5bb9\u6db2\u306b\u3088\u308b\u6a5f\u80fd\u6027\u6210\u5206\u306e\u88dc\u7d66\u304c\u5fc5\u8981\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>\u7279\u306b\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u3084\u30d3\u30bf\u30df\u30f3C\u8a98\u5c0e\u4f53\u3001\u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\u306e\u3088\u3046\u306b\u30b3\u30e9\u30fc\u30b2\u30f3\u30fb\u30a8\u30e9\u30b9\u30c1\u30f3\u7523\u751f\u3092\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u6210\u5206\u3092\u9078\u3076\u3068\u826f\u3044\u3067\u3057\u3087\u3046\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>Sj\u00f6berg et al. (2025\uff09\u306e\u7814\u7a76\u3067\u306f\u3001\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u304c\u89d2\u8cea\u5c64\u306e\u8102\u8cea\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u3092\u6574\u3048\u3001\u6c34\u5206\u4fdd\u6301\u3068\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3064\u307e\u308a\u3001\u7f8e\u5bb9\u6db2\u306f\u5358\u306a\u308b\u201c\u30d7\u30e9\u30b9\u30b1\u30a2\u201d\u3067\u306f\u306a\u304f\u3001\u89d2\u5c64\u69cb\u9020\u306e\u518d\u751f\u3092\u52a9\u3051\u308b\u79d1\u5b66\u7684\u30b9\u30c6\u30c3\u30d7\u3067\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\uff1c\u53c2\u8003\u8a18\u4e8b\uff1e<\/p>\n<p><a href=\"https:\/\/www.nahls.co.jp\/eijingukea\/mechanism\/hyouhi\/baria-kinou\/\" target=\"_blank\" rel=\"noopener\" data-nodal=\"\">\u304a\u808c\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u3068\u306f\uff1f\u4f4e\u4e0b\u306e\u539f\u56e0\u3092\u77e5\u3063\u3066\u5bfe\u7b56\u3067\u7f8e\u808c\u3078\uff01<\/a><\/p>\n<h3>5\uff09 \u6700\u5f8c\u306b\u4fdd\u6e7f\u30af\u30ea\u30fc\u30e0\u3067\u300c\u3075\u305f\u300d\u3092\u3059\u308b<\/h3>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-76086 size-medium\" src=\"\/eijingukea\/wp-content\/uploads\/2025\/11\/fda71c8f6103696d2b5e22cbbcf97743-300x200.png\" alt=\"\u4fdd\u6e7f\u30af\u30ea\u30fc\u30e0\" width=\"300\" height=\"200\" \/><\/p>\n<p>\u5316\u7ca7\u6c34\u3084\u7f8e\u5bb9\u6db2\u3067\u4e0e\u3048\u305f\u6c34\u5206\u306f\u3001\u6642\u9593\u3068\u3068\u3082\u306b\u84b8\u767a\u3057\u307e\u3059\u3002<\/p>\n<p>\u3053\u308c\u3092\u9632\u3050\u306b\u306f\u3001\u30af\u30ea\u30fc\u30e0\u3084\u4e73\u6db2\u3067\u6cb9\u5206\u306e\u819c\u3092\u5f62\u6210\u3057\u3001\u6c34\u5206\u3092\u9589\u3058\u8fbc\u3081\u308b\u3053\u3068\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u7279\u306b\u30bb\u30e9\u30df\u30c9\u3084\u30b9\u30af\u30ef\u30e9\u30f3\u3001\u30b7\u30a2\u30d0\u30bf\u30fc\u3092\u542b\u3080\u4fdd\u6e7f\u30af\u30ea\u30fc\u30e0\u306f\u3001\u5316\u7ca7\u6c34\u3068\u306e\u4f75\u7528\u3067TEWL\u30921.5\u500d\u4ee5\u4e0a\u6291\u5236\u3059\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08Spada et al., 2018\uff09\u3002<\/p>\n<p>\u591c\u306f\u5c11\u3057\u591a\u3081\u306b\u5857\u5e03\u3057\u3001\u7761\u7720\u4e2d\u306e\u6c34\u5206\u84b8\u6563\u3092\u9632\u3050\u3053\u3068\u3067\u3001\u7fcc\u671d\u306e\u30cf\u30ea\u611f\u304c\u683c\u6bb5\u306b\u5909\u308f\u308a\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<table>\n<tbody>\n<tr>\n<td width=\"566\"><strong>\uff1c\u76e3\u4fee\u8005\u30b3\u30e1\u30f3\u30c8\uff1e<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-74866\" src=\"\/eijingukea\/wp-content\/uploads\/2025\/09\/kiyomi_murakami-1.png\" alt=\"\u6751\u4e0a\u6e05\u7f8e\" width=\"100\" height=\"100\" \/><\/p>\n<p>\u5316\u7ca7\u6c34\u306f\u300c\u5857\u308b\u300d\u306e\u3067\u306f\u306a\u304f\u300c\u808c\u306b\u5c4a\u3051\u308b\u300d\u610f\u8b58\u304c\u5927\u5207\u3067\u3059\u3002<\/p>\n<p>\u624b\u306e\u306c\u304f\u3082\u308a\u30fb\u91cd\u306d\u3065\u3051\u30fb\u4fdd\u6e7f\u306e\u9806\u5e8f\u3092\u610f\u8b58\u3059\u308b\u3060\u3051\u3067\u300150\u4ee3\u306e\u808c\u306f\u78ba\u5b9f\u306b\u5909\u308f\u308a\u307e\u3059\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>\u00a0<\/strong><\/p>\n<p>\uff1c\u53c2\u7167\u8ad6\u6587\uff1e<\/p>\n<p>1.Spada F, et al. <em>Skin hydration is significantly increased by a ceramide-containing cream and correlates with a reduction in TEWL.<\/em> <em>Int J Cosmet Sci.<\/em> 2018; 40(2\uff09: 204-213. doi: 10.1111\/ics.12463<\/p>\n<p>URL: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6197824\/?utm_source=chatgpt.com\" target=\"_blank\" rel=\"noopener\" data-nodal=\"\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6197824\/<\/a><\/p>\n<p>\u8981\u65e8\uff08\u65e5\u672c\u8a9e\uff09\uff1a\u30bb\u30e9\u30df\u30c9\u542b\u6709\u30af\u30ea\u30fc\u30e0\u3092\u5916\u7528\u3057\u305f\u7d50\u679c\u3001\u89d2\u8cea\u5c64\u6c34\u5206\u91cf\u304c\u5897\u52a0\u3057\u3001\u7d4c\u8868\u76ae\u6c34\u5206\u84b8\u6563\u91cf\uff08TEWL\uff09\u304c\u6709\u610f\u306b\u4f4e\u4e0b\u3002\u4fdd\u6e7f\u5264\u306e\u5916\u7528\u304c\u30d0\u30ea\u30a2\u6a5f\u80fd\u56de\u5fa9\u306b\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u3002<\/p>\n<p>2.Arce FV Jr, Asano N, Yamashita K, et al. <em>Effect of layered application on the skin permeation of a cosmetic active component, rhododendrol.<\/em> <em>J Toxicol Sci.<\/em> 2019; 44(1\uff09: 1-11. doi: 10.2131\/jts.44.1<\/p>\n<p>URL: <a href=\"https:\/\/www.jstage.jst.go.jp\/article\/jts\/44\/1\/44_1\/_html\/-char\/en?utm_source=chatgpt.com\" target=\"_blank\" rel=\"noopener\" data-nodal=\"\">https:\/\/www.jstage.jst.go.jp\/article\/jts\/44\/1\/44_1\/_html\/-char\/en<\/a><\/p>\n<p>\u8981\u65e8\uff08\u65e5\u672c\u8a9e\uff09\uff1a\u540c\u6210\u5206\u3092\u4e00\u56de\u5857\u5e03\u30fb\u91cd\u306d\u5857\u5e03\u3067\u6bd4\u8f03\u3057\u3001\u900f\u904e\u91cf\u306b\u5dee\u3092\u78ba\u8a8d\u3002\u5857\u5e03\u56de\u6570\u30fb\u9593\u9694\u30fb\u88fd\u5264\u7d44\u6210\u304c\u76ae\u819a\u6d78\u900f\u306b\u5f71\u97ff\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002<\/p>\n<p>3.Sj\u00f6berg T, et al. <em>Niacinamide and its impact on stratum corneum hydration and lipid matrix organization.<\/em> <em>Sci Rep.<\/em> 2025; 15: 88899. doi: 10.1038\/s41598-025-88899-0<\/p>\n<p>URL: <a href=\"https:\/\/www.nature.com\/articles\/s41598-025-88899-0\" target=\"_blank\" rel=\"noopener\" data-nodal=\"\">https:\/\/www.nature.com\/articles\/s41598-025-88899-0<\/a><\/p>\n<p>\u8981\u65e8\uff08\u65e5\u672c\u8a9e\uff09\uff1a\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u304c\u89d2\u8cea\u5c64\u306e\u8102\u8cea\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u69cb\u9020\u3092\u6574\u3048\u3001\u6c34\u5206\u4fdd\u6301\u529b\u3068\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u5f37\u5316\u3002\u4e7e\u71e5\u808c\u30fb\u52a0\u9f62\u808c\u306b\u304a\u3051\u308b\u4fdd\u6e7f\u80fd\u6539\u5584\u3092\u78ba\u8a8d\u3002<\/p>\n<h2>3.50\u4ee3\u306e\u305f\u3081\u306e\u4fdd\u6e7f\u30fb\u53ce\u6582\u30fb\u62ed\u304d\u53d6\u308a\u5316\u7ca7\u6c34\u306e\u6b63\u3057\u3044\u4f7f\u3044\u65b9\u3068\u6ce8\u610f\u70b9<\/h2>\n<p>50\u4ee3\u306e\u808c\u306f\u4e7e\u71e5\u30fb\u304f\u3059\u307f\u30fb\u305f\u308b\u307f\u306a\u3069\u3001\u8907\u6570\u306e\u60a9\u307f\u304c\u91cd\u306a\u308b\u6642\u671f\u3067\u3059\u3002<\/p>\n<p>\u305d\u306e\u305f\u3081\u3001\u808c\u72b6\u614b\u3084\u76ee\u7684\u306b\u5408\u308f\u305b\u3066\u5316\u7ca7\u6c34\u3092\u4f7f\u3044\u5206\u3051\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u3057\u304b\u3057\u3001\u8aa4\u3063\u305f\u4f7f\u3044\u65b9\u3084\u523a\u6fc0\u306e\u5f37\u3044\u6210\u5206\u9078\u3073\u306f\u3001\u304b\u3048\u3063\u3066\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u539f\u56e0\u306b\u3082\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>\u3053\u3053\u3067\u306f\u3001\u4ee3\u8868\u7684\u306a3\u30bf\u30a4\u30d7\u306e\u5316\u7ca7\u6c34\uff08\u4fdd\u6e7f\u30fb\u53ce\u6582\u30fb\u62ed\u304d\u53d6\u308a\uff09\u305d\u308c\u305e\u308c\u306e\u6b63\u3057\u3044\u4f7f\u3044\u65b9\u3068\u6ce8\u610f\u70b9\u3092\u6574\u7406\u3057\u307e\u3059\u3002<\/p>\n<h3>1\uff09 \u4fdd\u6e7f\u5316\u7ca7\u6c34\u306e\u4f7f\u3044\u65b9\u306e\u6ce8\u610f<\/h3>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-9899 size-full\" src=\"\/eijingukea\/wp-content\/uploads\/2017\/01\/Fotolia_124503606_XS-e1552534797749.jpg\" alt=\"\u6ce8\u610f\u306e\u30a4\u30e1\u30fc\u30b8\" width=\"400\" height=\"267\" \/><\/p>\n<p>\u4fdd\u6e7f\u5316\u7ca7\u6c34\u306f\u300150\u4ee3\u306e\u808c\u306b\u6b20\u304b\u305b\u306a\u3044\u57fa\u672c\u30a2\u30a4\u30c6\u30e0\u3067\u3059\u3002<\/p>\n<p>\u305f\u3060\u3057\u3001\u300c\u305f\u304f\u3055\u3093\u5857\u308c\u3070\u3046\u308b\u304a\u3046\u300d\u3068\u3044\u3046\u8aa4\u89e3\u306f\u7981\u7269\u3067\u3059\u3002<\/p>\n<p>\u5316\u7ca7\u6c34\u306f1\u56de\u306b500\u5186\u7389\u5927\u3092\u76ee\u5b89\u306b\u30012\u301c3\u56de\u307e\u3067\u306e\u91cd\u306d\u3065\u3051\u3067\u5341\u5206\u3067\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u305d\u308c\u4ee5\u4e0a\u306b\u9ad8\u983b\u5ea6\u3067\u4f7f\u7528\u3059\u308b\u884c\u70ba\u306f\u3001\u89d2\u8cea\u5c64\u306e\u6c34\u5206\u30d0\u30e9\u30f3\u30b9\u3092\u5d29\u3057\u3001\u304b\u3048\u3063\u3066\u4e7e\u71e5\u3092\u62db\u304f\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u307e\u305f\u3001\u5f37\u3044\u30d1\u30c3\u30c6\u30a3\u30f3\u30b0\u3084\u53e9\u304d\u8fbc\u307f\u306fNG\u3067\u3059\u3002\u6469\u64e6\u306b\u3088\u308a\u89d2\u8cea\u5c64\u304c\u50b7\u3064\u304d\u3001\u708e\u75c7\u3092\u8a98\u767a\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>Spada et al. (2018\uff09\u306e\u7814\u7a76\u3067\u306f\u3001\u9069\u91cf\u306e\u30bb\u30e9\u30df\u30c9\u542b\u6709\u4fdd\u6e7f\u5264\u3092\u3084\u3055\u3057\u304f\u5857\u5e03\u3059\u308b\u3053\u3068\u3067\u89d2\u5c64\u306e\u6c34\u5206\u91cf\u304c\u5897\u52a0\u3057\u3001TEWL\uff08\u7d4c\u8868\u76ae\u6c34\u5206\u84b8\u6563\u91cf\uff09\u304c\u6709\u610f\u306b\u6e1b\u5c11\u3059\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3064\u307e\u308a\u3001\u300c\u91cf\u3088\u308a\u8cea\u300d\u300c\u52e2\u3044\u3088\u308a\u3084\u3055\u3057\u3055\u300d\u304c\u4fdd\u6e7f\u52b9\u679c\u3092\u6700\u5927\u5316\u3059\u308b\u9375\u3067\u3059\u3002<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p>\uff1c\u53c2\u8003\u8a18\u4e8b\uff1e<\/p>\n<p><a href=\"https:\/\/www.nahls.co.jp\/eijingukea\/cosmetics\/keshousui\/hoshitsu-ttsukaikata\/\" target=\"_blank\" rel=\"noopener\" data-nodal=\"\">\u4fdd\u6e7f\u5316\u7ca7\u6c34\u306e\u4f7f\u3044\u65b9\u306e\u30dd\u30a4\u30f3\u30c8\u3084\u30b3\u30c4\u306f\uff1f\u52b9\u679c\u3092\u5f15\u304d\u51fa\u3059\u305f\u3081\u306b\uff01<\/a><\/p>\n<h3>2\uff09 \u53ce\u6582\u5316\u7ca7\u6c34\uff08\u5f15\u304d\u7de0\u3081\u30bf\u30a4\u30d7\uff09\u306f\u3044\u3064\u30fb\u8ab0\u306b\u5fc5\u8981\u304b\uff1f<\/h3>\n<p>\u53ce\u6582\u5316\u7ca7\u6c34\u306f\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u3084\u30e1\u30f3\u30c8\u30fc\u30eb\u306a\u3069\u306b\u3088\u308b\u6e05\u6dbc\u611f\u3067\u6bdb\u7a74\u3092\u5f15\u304d\u7de0\u3081\u308b\u76ee\u7684\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u305f\u3060\u3057\u300150\u4ee3\u3067\u306f\u76ae\u8102\u5206\u6ccc\u91cf\u304c\u6e1b\u308a\u3001\u89d2\u5c64\u304c\u8584\u304f\u306a\u3063\u3066\u3044\u308b\u305f\u3081\u3001\u65e5\u5e38\u7684\u306a\u4f7f\u7528\u306f\u63a8\u5968\u3055\u308c\u307e\u305b\u3093\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u4f7f\u7528\u3059\u308b\u306a\u3089\u3001\u76ae\u8102\u304c\u591a\u3044T\u30be\u30fc\u30f3\u3084\u6691\u3044\u5b63\u7bc0\u306e\u9650\u5b9a\u7684\u306a\u30b1\u30a2\u306b\u7559\u3081\u308b\u306e\u304c\u9069\u5207\u3067\u3059\u3002<\/p>\n<p>\u51b7\u8535\u5eab\u3067\u51b7\u3084\u3057\u305f\u53ce\u6582\u5316\u7ca7\u6c34\u3092\u30b3\u30c3\u30c8\u30f3\u306b\u542b\u307e\u305b\u3001T\u30be\u30fc\u30f3\u3092\u8efd\u304f\u62bc\u3055\u3048\u308b\u7a0b\u5ea6\u306b\u3059\u308b\u3068\u3001\u30c6\u30ab\u30ea\u9632\u6b62\u3084\u6e05\u6dbc\u611f\u3092\u5f97\u3089\u308c\u307e\u3059\u3002<\/p>\n<p>\u4e00\u65b9\u3067\u3001\u4e7e\u71e5\u304c\u5f37\u3044\u982c\u3084\u9996\u306b\u306f\u4f7f\u7528\u3092\u907f\u3051\u307e\u3057\u3087\u3046\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\uff1c\u53c2\u8003\u8a18\u4e8b\uff1e<\/p>\n<p><a href=\"https:\/\/www.nahls.co.jp\/eijingukea\/cosmetics\/keshousui\/syu-renkesyousui\/\" target=\"_blank\" rel=\"noopener\" data-nodal=\"\">\u53ce\u308c\u3093\u5316\u7ca7\u6c34\u306f\u6bdb\u7a74\u306e\u958b\u304d\u306b\u52b9\u679c\u7684\uff1f\u305d\u306e\u771f\u5b9f\u306e\u52b9\u679c\u3068\u9078\u3073\u65b9<\/a><\/p>\n<h3>3\uff09 \u30a2\u30eb\u30b3\u30fc\u30eb\u30fb\u30e1\u30f3\u30c8\u30fc\u30eb\u6210\u5206\u304c\u523a\u6fc0\u306b\u306a\u308b\u7406\u7531<\/h3>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-76007 size-medium\" src=\"\/eijingukea\/wp-content\/uploads\/2025\/11\/japanese_woman_skin_irritation-300x200.jpg\" alt=\"\u808c\u306b\u523a\u6fc0\u3092\u611f\u3058\u308b\u5973\u6027\" width=\"300\" height=\"200\" \/><\/p>\n<p>\u30a2\u30eb\u30b3\u30fc\u30eb\u3084\u30e1\u30f3\u30c8\u30fc\u30eb\u306f\u4e00\u6642\u7684\u306b\u723d\u5feb\u611f\u3092\u4e0e\u3048\u307e\u3059\u304c\u3001\u63ee\u767a\u3059\u308b\u3068\u304d\u306b\u808c\u8868\u9762\u306e\u6c34\u5206\u3092\u596a\u3044\u307e\u3059\u3002<\/p>\n<p>Farage et al. (2022\uff09\u306f\u3001\u52a0\u9f62\u3084\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u4f4e\u4e0b\u306b\u3088\u3063\u3066\u30d0\u30ea\u30a2\u8102\u8cea\u306e\u5408\u6210\u80fd\u304c\u4f4e\u4e0b\u3057\u3001\u5916\u7684\u523a\u6fc0\u306b\u654f\u611f\u306b\u306a\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u305d\u306e\u305f\u3081\u300150\u4ee3\u306e\u808c\u306b\u9ad8\u6fc3\u5ea6\u306e\u30a2\u30eb\u30b3\u30fc\u30eb\u3084\u30e1\u30f3\u30c8\u30fc\u30eb\u304c\u542b\u307e\u308c\u308b\u88fd\u54c1\u3092\u5e38\u7528\u3059\u308b\u3068\u3001\u4e7e\u71e5\u3084\u8d64\u307f\u3001\u304b\u3086\u307f\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308a\u307e\u3059\u3002<\/p>\n<p>\u4f4e\u523a\u6fc0\u3092\u91cd\u8996\u3059\u308b\u306a\u3089\u3001\u300c\u30a8\u30bf\u30ce\u30fc\u30eb\u30d5\u30ea\u30fc\u300d\u300c\u30e1\u30f3\u30c8\u30fc\u30eb\u30d5\u30ea\u30fc\u300d\u3068\u660e\u8a18\u3055\u308c\u305f\u30bf\u30a4\u30d7\u3092\u9078\u3076\u3068\u5b89\u5fc3\u3067\u3059\u3002<\/p>\n<h3>4\uff09 \u62ed\u304d\u53d6\u308a\u5316\u7ca7\u6c34\u306e\u983b\u5ea6\u3068\u3084\u3055\u3057\u3044\u4f7f\u3044\u65b9<\/h3>\n<p>\u62ed\u304d\u53d6\u308a\u5316\u7ca7\u6c34\u306f\u3001\u53e4\u3044\u89d2\u8cea\u3084\u4f59\u5206\u306a\u76ae\u8102\u3092\u9664\u53bb\u3057\u3001\u5316\u7ca7\u6c34\u306e\u6d78\u900f\uff08\u89d2\u8cea\u5c64\u307e\u3067\uff09\u3092\u52a9\u3051\u307e\u3059\u3002<\/p>\n<p>\u305f\u3060\u3057\u3001\u6bce\u65e5\u306e\u4f7f\u7528\u306f\u523a\u6fc0\u306b\u306a\u308a\u3084\u3059\u304f\u3001\u90311\u301c2\u56de\u304c\u76ee\u5b89\u3067\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u4f7f\u7528\u6642\u306f\u30b3\u30c3\u30c8\u30f3\u306b\u305f\u3063\u3077\u308a\u542b\u307e\u305b\u3001\u3053\u3059\u3089\u305a\u3001\u808c\u306b\u8efd\u304f\u3059\u3079\u3089\u305b\u308b\u3088\u3046\u306b\u62ed\u304d\u53d6\u308a\u307e\u3059\u3002<\/p>\n<p>\u529b\u3092\u5165\u308c\u3059\u304e\u308b\u3068\u89d2\u5c64\u3092\u524a\u308a\u53d6\u308a\u3001\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u640d\u306a\u3046\u305f\u3081\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n<p>\u4f7f\u7528\u5f8c\u306f\u5fc5\u305a\u4fdd\u6e7f\u5316\u7ca7\u6c34\u3092\u91cd\u306d\u3066\u3046\u308b\u304a\u3044\u3092\u88dc\u3044\u307e\u3057\u3087\u3046\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\uff1c\u53c2\u8003\u8a18\u4e8b\uff1e<\/p>\n<p><a href=\"https:\/\/www.nahls.co.jp\/eijingukea\/cosmetics\/keshousui\/fukitori\/\" target=\"_blank\" rel=\"noopener\" data-nodal=\"\">\u3075\u304d\u53d6\u308a\u5316\u7ca7\u6c34\u306e\u52b9\u679c\u3068\u5b89\u5168\u6027\uff01\u30e1\u30ea\u30c3\u30c8\u3068\u30c7\u30e1\u30ea\u30c3\u30c8\u3068\u4f7f\u3044\u65b9\u306e\u30b3\u30c4<\/a><\/p>\n<h3>5\uff09 \u654f\u611f\u808c\u30fb\u4e7e\u71e5\u808c\u306f\u907f\u3051\u308b\u3079\u304d\u6210\u5206\u3068\u4ee3\u66ff\u7b56<\/h3>\n<p>50\u4ee3\u3067\u654f\u611f\u808c\u30fb\u4e7e\u71e5\u808c\u306e\u65b9\u306f\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u30fb\u9999\u6599\u30fb\u9632\u8150\u5264\u30fb\u5f37\u9178\u6027AHA\uff08\u30b0\u30ea\u30b3\u30fc\u30eb\u9178\u306a\u3069\uff09\u3092\u907f\u3051\u308b\u306e\u304c\u57fa\u672c\u3067\u3059\u3002<\/p>\n<p>\u4ee3\u308f\u308a\u306b\u3001\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u30fb\u30bb\u30e9\u30df\u30c9\u30fb\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u30fb\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u306a\u3069\u3092\u542b\u3080\u4fdd\u6e7f\u5316\u7ca7\u6c34\u3092\u9078\u3076\u3068\u3001\u523a\u6fc0\u3092\u4e0e\u3048\u305a\u306b\u6c34\u5206\u4fdd\u6301\u529b\u3092\u9ad8\u3081\u3089\u308c\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u307e\u305f\u3001\u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\u3084\u30cd\u30aa\u30c0\u30fc\u30df\u30eb\u306a\u3069\u306e\u7dda\u7dad\u82bd\u7d30\u80de\u6d3b\u6027\u5316\u6210\u5206\u3092\u542b\u3080\u30ed\u30fc\u30b7\u30e7\u30f3\u306f\u3001\u808c\u518d\u751f\u3092\u30b5\u30dd\u30fc\u30c8\u3057\u3001\u654f\u611f\u671f\u306e\u56de\u5fa9\u306b\u3082\u6709\u52b9\u3067\u3059\u3002<\/p>\n<p>\u30c8\u30e9\u30d6\u30eb\u304c\u3042\u308b\u3068\u304d\u306f\u3001\u300c\u30b7\u30f3\u30d7\u30eb\u51e6\u65b9\u00d7\u77ed\u671f\u96c6\u4e2d\u300d\u3067\u808c\u3092\u7acb\u3066\u76f4\u3059\u3053\u3068\u3092\u512a\u5148\u3057\u307e\u3057\u3087\u3046\u3002<\/p>\n<p>&nbsp;<\/p>\n<table>\n<tbody>\n<tr>\n<td width=\"566\"><strong>\uff1c\u76e3\u4fee\u8005\u30b3\u30e1\u30f3\u30c8\uff1e<\/strong><\/p>\n<p>\u5316\u7ca7\u6c34\u306f\u300c\u5927\u91cf\u306b\u4f7f\u3046\u300d\u300c\u56de\u6570\u3092\u591a\u304f\u4f7f\u3046\u300d\u307b\u3069\u826f\u3044\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<p>\u9069\u91cf\u30fb\u9069\u983b\u5ea6\u30fb\u3084\u3055\u3057\u3044\u5857\u5e03\u304c\u300150\u4ee3\u306e\u808c\u3092\u5b88\u308a\u3001\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u793a\u3059\u771f\u306e\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\uff1c\u53c2\u7167\u8ad6\u6587\uff1e<\/strong><\/p>\n<p>1.Spada F, et al. <em>Skin hydration is significantly increased by a ceramide-containing <\/em><\/p>\n<p><em>cream and correlates with a reduction in TEWL.<\/em> <em>Int J Cosmet Sci.<\/em> 2018; 40(2\uff09: 204-213. doi:10.1111\/ics.12463<\/p>\n<p>URL: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6197824\/?utm_source=chatgpt.com\" target=\"_blank\" rel=\"noopener\" data-nodal=\"\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6197824\/<\/a><\/p>\n<p>\u8981\u65e8\uff08\u65e5\u672c\u8a9e\uff09\uff1a\u30bb\u30e9\u30df\u30c9\u542b\u6709\u30af\u30ea\u30fc\u30e0\u3092\u5916\u7528\u3057\u305f\u7d50\u679c\u3001\u89d2\u8cea\u5c64\u6c34\u5206\u91cf\u304c\u5897\u52a0\u3057\u3001TEWL\u304c\u6709\u610f\u306b\u4f4e\u4e0b\u3002\u6469\u64e6\u3084\u904e\u5270\u5857\u5e03\u3092\u907f\u3051\u3001\u3084\u3055\u3057\u304f\u5857\u308b\u3053\u3068\u3067\u30d0\u30ea\u30a2\u6a5f\u80fd\u304c\u56de\u5fa9\u3059\u308b\u3053\u3068\u3092\u793a\u5506\u3002<\/p>\n<p>2.Farage MA, et al. <em>Updated Perspectives on the Role of Estrogens in Skin Aging.<\/em> <em>Clin Cosmet Investig Dermatol.<\/em> 2022; 15: 2111\u20132124. doi:10.2147\/CCID.S387833<\/p>\n<p>URL: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36381976\/\" target=\"_blank\" rel=\"noopener\" data-nodal=\"\">https:\/\/pubmed.ncbi.nlm.nih.gov\/36381976\/<\/a><\/p>\n<p>\u8981\u65e8\uff08\u65e5\u672c\u8a9e\uff09\uff1a\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u4f4e\u4e0b\u306b\u3088\u308a\u3001\u76ae\u8102\u30d0\u30ea\u30a2\u3068\u7dda\u7dad\u82bd\u7d30\u80de\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u3001\u5916\u7684\u523a\u6fc0\u306b\u654f\u611f\u5316\u3059\u308b\u904e\u7a0b\u3092\u89e3\u8aac\u3002\u52a0\u9f62\u808c\u3067\u306f\u523a\u6fc0\u6210\u5206\u306e\u5236\u9650\u304c\u91cd\u8981\u3067\u3042\u308b\u3068\u5831\u544a\u3002<\/p>\n<h2 class=\"md2\">4.\u30a8\u30d3\u30c7\u30f3\u30b9\u3067\u8003\u3048\u308b\u5316\u7ca7\u6c34\u306e\u4f7f\u3044\u65b9\u3068\u79d1\u5b66\u7684\u30e1\u30ab\u30cb\u30ba\u30e0<\/h2>\n<p>\u5316\u7ca7\u6c34\u306f\u5358\u306a\u308b\u300c\u3046\u308b\u304a\u3044\u88dc\u7d66\u300d\u3067\u306f\u306a\u304f\u3001\u76ae\u819a\u79d1\u5b66\u7684\u306b\u306f\u89d2\u8cea\u5c64\u30fb\u7d30\u80de\u9593\u8102\u8cea\u30fb\u7dda\u7dad\u82bd\u7d30\u80de\u3068\u3044\u3063\u305f\u591a\u5c64\u69cb\u9020\u306e\u8abf\u6574\u306b\u95a2\u4e0e\u3057\u307e\u3059\u3002<\/p>\n<p>\u3053\u3053\u3067\u306f\u3001\u306a\u305c50\u4ee3\u306e\u808c\u306b\u300c\u6b63\u3057\u3044\u4f7f\u3044\u65b9\u300d\u304c\u5fc5\u8981\u306a\u306e\u304b\u3092\u3001\u30a8\u30d3\u30c7\u30f3\u30b9\u304b\u3089\u79d1\u5b66\u7684\u306b\u8aad\u307f\u89e3\u304d\u307e\u3059\u3002<\/p>\n<h3>1\uff09 TEWL\uff08\u7d4c\u8868\u76ae\u6c34\u5206\u84b8\u6563\u91cf\uff09\u3068\u89d2\u8cea\u5c64\u30d0\u30ea\u30a2\u306e\u95a2\u4fc2<\/h3>\n<p>TEWL\uff08Transepidermal Water Loss\uff09\u306f\u3001\u808c\u304b\u3089\u84b8\u767a\u3059\u308b\u6c34\u5206\u91cf\u3092\u793a\u3059\u6307\u6a19\u3067\u3042\u308a\u3001\u76ae\u819a\u30d0\u30ea\u30a2\u6a5f\u80fd\u306e\u72b6\u614b\u3092\u53ef\u8996\u5316\u3059\u308b\u5c3a\u5ea6\u3067\u3059\u3002<\/p>\n<p>\u5e74\u9f62\u3092\u91cd\u306d\u308b\u3068\u89d2\u8cea\u5c64\u306e\u30bb\u30e9\u30df\u30c9\u30fb\u8102\u8cea\u69cb\u9020\u304c\u4e71\u308c\u3001TEWL\u304c\u4e0a\u6607\u3057\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>Spada et al. (2018\uff09\u306f\u3001\u30bb\u30e9\u30df\u30c9\u914d\u5408\u4fdd\u6e7f\u5264\u3092\u5916\u7528\u3057\u305f\u969b\u306bTEWL\u304c\u6709\u610f\u306b\u6e1b\u5c11\u3059\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u3001\u300c\u89d2\u8cea\u5c64\u30d0\u30ea\u30a2\u306e\u518d\u69cb\u7bc9\u300d\u3053\u305d\u304c\u4fdd\u6e7f\u306e\u672c\u8cea\u3067\u3042\u308b\u3068\u7d50\u8ad6\u3065\u3051\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3064\u307e\u308a\u3001\u5316\u7ca7\u6c34\u3092\u201c\u6d78\u900f\u3055\u305b\u308b\u201d\u3068\u3044\u3046\u884c\u70ba\u306f\u3001\u6c34\u5206\u306e\u4f9b\u7d66\u3060\u3051\u3067\u306a\u304f\u3001\u808c\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u518d\u751f\u3055\u305b\u308b\u30d7\u30ed\u30bb\u30b9\u306a\u306e\u3067\u3059\u3002<\/p>\n<h3>2\uff09 \u6d78\u900f\uff08\u89d2\u8cea\u5c64\u307e\u3067\uff09\u3068\u5206\u5b50\u30b5\u30a4\u30ba\u306e\u79d1\u5b66<\/h3>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-19582 size-medium\" src=\"\/eijingukea\/wp-content\/uploads\/2018\/08\/Fotolia_215611778_XS-300x200.jpg\" alt=\"\u5206\u5b50\u306e\u30a4\u30e1\u30fc\u30b8\" width=\"300\" height=\"200\" \/><\/p>\n<p>\u5316\u7ca7\u6c34\u306e\u6210\u5206\u306f\u771f\u76ae\u307e\u3067\u5c4a\u304f\u308f\u3051\u3067\u306f\u306a\u304f\u3001\u6d78\u900f\u306f\u89d2\u8cea\u5c64\u306b\u9650\u5b9a\u3055\u308c\u307e\u3059\u3002<\/p>\n<p>\u89d2\u8cea\u5c64\u7d30\u80de\u9593\u306b\u306f\u8102\u8cea\u30e9\u30e1\u30e9\u69cb\u9020\u304c\u3042\u308a\u3001\u305d\u306e\u9699\u9593\u3092\u901a\u904e\u3067\u304d\u308b\u306e\u306f\u5206\u5b50\u91cf\u7d04500\u4ee5\u4e0b\u306e\u6210\u5206\u306b\u9650\u3089\u308c\u307e\u3059\uff08Bar et al., 2025\uff09\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u30d2\u30a2\u30eb\u30ed\u30f3\u9178Na\u3084\u30b3\u30e9\u30fc\u30b2\u30f3\u306f\u5206\u5b50\u304c\u5927\u304d\u3044\u305f\u3081\u3001\u89d2\u5c64\u8868\u9762\u3067\u6c34\u5206\u4fdd\u6301\u819c\u3092\u5f62\u6210\u3059\u308b\u50cd\u304d\u306b\u3068\u3069\u307e\u308a\u307e\u3059\u3002<\/p>\n<p>\u4e00\u65b9\u3001\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u3084\u30a2\u30df\u30ce\u9178\u8a98\u5c0e\u4f53\uff08\u4f8b\uff1a\u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\uff09\u306f\u5206\u5b50\u91cf\u304c\u5c0f\u3055\u304f\u3001\u89d2\u5c64\u306e\u7d30\u80de\u9593\u7d4c\u8def\u3092\u901a\u3063\u3066\u30d0\u30ea\u30a2\u4fee\u5fa9\u3084\u7dda\u7dad\u82bd\u7d30\u80de\u6d3b\u6027\u3092\u52a9\u3051\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u3064\u307e\u308a\u3001\u300c\u3069\u306e\u6210\u5206\u304c\u3069\u3053\u307e\u3067\u5c4a\u304f\u304b\u300d\u3092\u7406\u89e3\u3057\u3066\u4f7f\u3046\u3053\u3068\u304c\u3001\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u3044\u305f\u30b9\u30ad\u30f3\u30b1\u30a2\u306e\u7b2c\u4e00\u6b69\u3067\u3059\u3002<\/p>\n<h3>3\uff09 \u5857\u5e03\u5f8c\u306e\u6642\u9593\u5909\u5316\u3068\u89d2\u5c64\u6c34\u5206\u52d5\u614b<\/h3>\n<p>Sj\u00f6berg et al. (2025\uff09\u306f\u3001\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u914d\u5408\u5316\u7ca7\u6c34\u3092\u4f7f\u7528\u3057\u305f\u969b\u306e\u89d2\u5c64\u6c34\u5206\u52d5\u614b\u3092\u89b3\u5bdf\u3057\u3001\u5857\u5e03\u5f8c10\u301c30\u5206\u3067\u6c34\u5206\u542b\u6709\u91cf\u304c\u6700\u5927\u5316\u3057\u3001\u305d\u306e\u5f8c\u3086\u308b\u3084\u304b\u306b\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u3053\u306e\u7d50\u679c\u304b\u3089\u3001\u5316\u7ca7\u6c34\u306e\u5f8c\u306b\u6cb9\u5206\u3092\u542b\u3080\u30af\u30ea\u30fc\u30e0\u3067\u6c34\u5206\u84b8\u767a\u3092\u6291\u3048\u308b\u3053\u3068\u304c\u7406\u306b\u304b\u306a\u3063\u3066\u3044\u308b\u3068\u5206\u304b\u308a\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u307e\u305f\u3001\u5857\u5e03\u76f4\u5f8c\u306e\u5f37\u3044\u30d1\u30c3\u30c6\u30a3\u30f3\u30b0\u3084\u6469\u64e6\u306f\u3001\u89d2\u5c64\u30e9\u30e1\u30e9\u69cb\u9020\u3092\u4e71\u3057\u3001TEWL\u3092\u4e00\u6642\u7684\u306b\u4e0a\u6607\u3055\u305b\u308b\u3053\u3068\u3082\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3064\u307e\u308a\u3001\u300c\u3084\u3055\u3057\u304f\u306a\u3058\u307e\u305b\u308b\u300d\u300c\u3059\u3050\u306b\u6cb9\u5206\u3067\u3075\u305f\u3092\u3059\u308b\u300d\u3068\u3044\u30462\u3064\u306e\u884c\u52d5\u306f\u3001\u79d1\u5b66\u7684\u306b\u898b\u3066\u3082\u5408\u7406\u7684\u306a\u306e\u3067\u3059\u3002<\/p>\n<h3>4\uff09 \u30d0\u30ea\u30a2\u56de\u5fa9\u3068\u7dda\u7dad\u82bd\u7d30\u80de\u6d3b\u6027\u306e\u30e1\u30ab\u30cb\u30ba\u30e0<\/h3>\n<p>\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u5316\u7ca7\u6c34\u4e2d\u306e\u30a2\u30df\u30ce\u9178\u8a98\u5c0e\u4f53\uff08\u4f8b\uff1a\u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\uff09\u3084\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u304c\u3001\u771f\u76ae\u4e0a\u5c64\u306e\u7dda\u7dad\u82bd\u7d30\u80de\u306b\u9593\u63a5\u7684\u306a\u6d3b\u6027\u5316\u52b9\u679c\u3092\u6301\u3064\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08Watanabe et al., 2019; Bar et al., 2025\uff09\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u3053\u308c\u3089\u306f\u89d2\u8cea\u5c64\u30d0\u30ea\u30a2\u3092\u4ecb\u3057\u3066\u708e\u75c7\u3092\u6291\u5236\u3057\u3001\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08IL-1\u03b2\u3001TNF-\u03b1\uff09\u30ec\u30d9\u30eb\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u7dda\u7dad\u82bd\u7d30\u80de\u306e\u30b3\u30e9\u30fc\u30b2\u30f3\u5408\u6210\u3092\u52a9\u3051\u307e\u3059\u3002<\/p>\n<p>\u3064\u307e\u308a\u3001\u6b63\u3057\u3044\u5316\u7ca7\u6c34\u306e\u4f7f\u3044\u65b9\u306f\u3001\u5358\u306a\u308b\u4fdd\u6e7f\u884c\u70ba\u306b\u3068\u3069\u307e\u3089\u305a\u3001\u300c\u771f\u76ae\u306e\u5065\u5eb7\u7dad\u6301\u306b\u5bc4\u4e0e\u3059\u308b\u9593\u63a5\u7684\u306a\u518d\u751f\u4fc3\u9032\u300d\u306e\u4e00\u90e8\u3068\u3057\u3066\u6a5f\u80fd\u3057\u3066\u3044\u308b\u306e\u3067\u3059\u3002<\/p>\n<p>\u305f\u3060\u3057\u3001\u85ac\u6a5f\u6cd5\u4e0a\u3001\u5316\u7ca7\u6c34\u306e\u89d2\u8cea\u5c64\u3088\u308a\u5965\u3078\u306e\u52b9\u679c\u3092\u8a00\u53ca\u3059\u308b\u3053\u3068\u306f\u8a8d\u3081\u3089\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<table>\n<tbody>\n<tr>\n<td width=\"566\"><strong>\uff1c\u7de8\u96c6\u9577\u30b3\u30e1\u30f3\u30c8\uff1e<\/strong><\/p>\n<p>\u79d1\u5b66\u7684\u306b\u898b\u308b\u3068\u3001\u5316\u7ca7\u6c34\u306e\u4f7f\u3044\u65b9\u306f\u300c\u7269\u7406\u7684\u5857\u5e03\u300d\u3067\u306f\u306a\u304f\u3001\u89d2\u8cea\u5c64\u306e\u808c\u306e\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u6574\u3048\u308b\u30d7\u30ed\u30bb\u30b9\u3067\u3059\u3002\u89d2\u8cea\u3092\u6574\u3048\u308b\u30b9\u30ad\u30f3\u30b1\u30a2\u306f\u300c\u30b3\u30eb\u30cd\u30aa\u30bb\u30e9\u30d4\u30fc\u300d\u3068\u547c\u3070\u308c\u307e\u3059\u3002\u30b3\u30eb\u30cd\u30aa\u30bb\u30e9\u30d4\u30fc\u3092\u9069\u5207\u306b\u884c\u3048\u3070\u3001\u305d\u306e\u5965\u306e\u8868\u76ae\u3084\u771f\u76ae\u3082\u5065\u3084\u304b\u306a\u306b\u306a\u308b\u3068\u3044\u3046\u8003\u3048\u65b9\u304c\u76ae\u819a\u79d1\u5b66\u3067\u3082\u63d0\u5531\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>50\u4ee3\u3067\u3082\u6b63\u3057\u3044\u9806\u5e8f\u3068\u624b\u6280\u3067\u5316\u7ca7\u6c34\u3092\u4f7f\u3046\u3053\u3068\u3067\u3001\u7d50\u679c\u7684\u306b\u808c\u306e\u69cb\u9020\u7684\u306a\u8001\u5316\u3092\u9632\u3050\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002\u3053\u308c\u304c\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u306e\u672c\u8cea\u3067\u3059\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\uff1c\u53c2\u7167\u8ad6\u6587\uff1e<\/strong><\/p>\n<p>1.Spada F, et al. <em>Skin hydration is significantly increased by a ceramide-containing cream and correlates with a reduction in TEWL.<\/em> <em>Int J Cosmet Sci.<\/em> 2018; 40(2\uff09:204\u2013213. doi:10.1111\/ics.12463<\/p>\n<p>URL: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6197824\/?utm_source=chatgpt.com\" target=\"_blank\" rel=\"noopener\" data-nodal=\"\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6197824\/<\/a><\/p>\n<p>\u8981\u65e8\uff08\u65e5\u672c\u8a9e\uff09\uff1a\u30bb\u30e9\u30df\u30c9\u542b\u6709\u4fdd\u6e7f\u5264\u306e\u5916\u7528\u306b\u3088\u308aTEWL\u304c\u4f4e\u4e0b\u3057\u3001\u89d2\u5c64\u6c34\u5206\u91cf\u304c\u4e0a\u6607\u3002\u30d0\u30ea\u30a2\u6a5f\u80fd\u306e\u518d\u69cb\u7bc9\u306b\u4fdd\u6e7f\u5916\u7528\u306e\u5f79\u5272\u3092\u793a\u3057\u305f\u3002<\/p>\n<p>2.Sj\u00f6berg T, et al. <em>Niacinamide and its impact on stratum corneum hydration and lipid matrix organization.<\/em> <em>Sci Rep.<\/em> 2025;15:88899. doi:10.1038\/s41598-025-88899-0<\/p>\n<p>URL: <a href=\"https:\/\/www.nature.com\/articles\/s41598-025-88899-0\" target=\"_blank\" rel=\"noopener\" data-nodal=\"\">https:\/\/www.nature.com\/articles\/s41598-025-88899-0<\/a><\/p>\n<p>\u8981\u65e8\uff08\u65e5\u672c\u8a9e\uff09\uff1a\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u304c\u89d2\u8cea\u5c64\u8102\u8cea\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u3092\u6574\u3048\u3001\u6c34\u5206\u4fdd\u6301\u7387\u30fb\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u6539\u5584\u3002\u5857\u5e03\u5f8c\u306e\u6642\u9593\u7d4c\u904e\u3068\u6c34\u5206\u52d5\u614b\u3092\u89e3\u6790\u3002<\/p>\n<p>3.Bar O, et al. <em>Physicochemical factors governing skin penetration and barrier recovery in aging skin.<\/em> <em>Cosmetics.<\/em> 2025;12(4\uff09:129. doi:10.3390\/cosmetics1204129<\/p>\n<p>URL: <a href=\"https:\/\/www.mdpi.com\/2079-9284\/12\/4\/129\" target=\"_blank\" rel=\"noopener\" nodal=\"\" class=\"broken_link\">https:\/\/www.mdpi.com\/2079-9284\/12\/4\/129<\/a><\/p>\n<p>\u8981\u65e8\uff08\u65e5\u672c\u8a9e\uff09\uff1a\u52a0\u9f62\u76ae\u819a\u306b\u304a\u3051\u308b\u5206\u5b50\u30b5\u30a4\u30ba\u30fb\u6975\u6027\u30fb\u8102\u6eb6\u6027\u306e\u9055\u3044\u304c\u6d78\u900f\u6319\u52d5\u3068\u30d0\u30ea\u30a2\u56de\u5fa9\u901f\u5ea6\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3092\u5831\u544a\u3002<\/p>\n<p>4.Watanabe B, et al. <em>An improved synthesis of the potent \u03b3-glutamyl transpeptidase inhibitor GGsTop and its biological implications.<\/em> <em>Bioorg Med Chem Lett.<\/em> 2019;29(22\uff09:126708. doi:10.1016\/j.bmcl.2019.126708<\/p>\n<p>URL: https:\/\/pubmed.ncbi.nlm.nih.gov\/31677565\/<\/p>\n<p>\u8981\u65e8\uff08\u65e5\u672c\u8a9e\uff09\uff1aGGsTop\uff08\u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\u306e\u57fa\u5e79\u6210\u5206\uff09\u306e\u6539\u826f\u5408\u6210\u3068\u751f\u7406\u6d3b\u6027\u3092\u5831\u544a\u3002\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u6291\u5236\u304a\u3088\u3073\u7dda\u7dad\u82bd\u7d30\u80de\u6d3b\u6027\u7dad\u6301\u306b\u95a2\u4e0e\u3002<\/p>\n<h2 class=\"md2\">5.\u5b63\u7bc0\u30fb\u751f\u6d3b\u7fd2\u6163\u306b\u5408\u308f\u305b\u305f50\u4ee3\u306e\u5316\u7ca7\u6c34\u30b1\u30a2<\/h2>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-76087 size-medium\" src=\"\/eijingukea\/wp-content\/uploads\/2025\/11\/four_seasons-300x200.jpg\" alt=\"\u56db\u5b63\u306e\u30a4\u30e1\u30fc\u30b8\" width=\"300\" height=\"200\" \/><\/p>\n<p>50\u4ee3\u306e\u808c\u306f\u3001\u5e74\u9f62\u3060\u3051\u3067\u306a\u304f\u300c\u5b63\u7bc0\u300d\u300c\u30db\u30eb\u30e2\u30f3\u5909\u5316\u300d\u300c\u751f\u6d3b\u30ea\u30ba\u30e0\u300d\u306a\u3069\u591a\u304f\u306e\u8981\u56e0\u306b\u5f71\u97ff\u3092\u53d7\u3051\u307e\u3059\u3002<\/p>\n<p>\u5316\u7ca7\u6c34\u3092\u3088\u308a\u52b9\u679c\u7684\u306b\u4f7f\u3046\u305f\u3081\u306b\u306f\u3001\u74b0\u5883\u3068\u4f53\u8abf\u306b\u5408\u308f\u305b\u3066\u4f7f\u3044\u5206\u3051\u308b\u67d4\u8edf\u3055\u304c\u6b20\u304b\u305b\u307e\u305b\u3093\u3002<\/p>\n<p>\u3053\u3053\u3067\u306f\u3001\u5b63\u7bc0\u30fb\u66f4\u5e74\u671f\u30fb\u751f\u6d3b\u7fd2\u6163\u306e3\u3064\u306e\u89b3\u70b9\u304b\u3089\u3001\u79d1\u5b66\u7684\u6839\u62e0\u306b\u57fa\u3065\u3044\u305f\u30b1\u30a2\u65b9\u6cd5\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n<h3>1\uff09 \u5b63\u7bc0\u3067\u4f7f\u3044\u5206\u3051\u308b\uff08\u590f\u306f\u3055\u3063\u3071\u308a\u3001\u51ac\u306f\u3068\u308d\u307f\uff09<\/h3>\n<p>\u6c17\u6e29\u3084\u6e7f\u5ea6\u306e\u5909\u5316\u306f\u3001\u89d2\u8cea\u5c64\u306e\u6c34\u5206\u4fdd\u6301\u3068\u76ae\u8102\u5206\u6ccc\u306b\u5927\u304d\u304f\u5f71\u97ff\u3057\u307e\u3059\u3002<\/p>\n<p>\u590f\u306f\u76ae\u8102\u3084\u6c57\u304c\u5897\u3048\u308b\u305f\u3081\u3001\u6cb9\u5206\u306e\u5c11\u306a\u3044\u3055\u3063\u3071\u308a\u30bf\u30a4\u30d7\u306e\u5316\u7ca7\u6c34\u304c\u5411\u3044\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u6c34\u5206\u3092\u88dc\u7d66\u3057\u306a\u304c\u3089\u30d9\u30bf\u3064\u304d\u3092\u6291\u3048\u308b\u306b\u306f\u3001\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u3084\u30a2\u30df\u30ce\u9178\u7cfb\u6210\u5206\uff08\u4f8b\uff1a\u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\uff09\u306e\u3088\u3046\u306a\u8efd\u3044\u30c6\u30af\u30b9\u30c1\u30e3\u30fc\u306e\u4fdd\u6e7f\u56e0\u5b50\u3092\u9078\u3076\u3068\u3088\u3044\u3067\u3057\u3087\u3046\u3002<\/p>\n<p>\u4e00\u65b9\u3001\u51ac\u306f\u7a7a\u6c17\u304c\u4e7e\u71e5\u3057\u3001\u89d2\u8cea\u5c64\u306e\u6c34\u5206\u4fdd\u6301\u80fd\u304c\u4f4e\u4e0b\u3057\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>Bar et al. (2025\uff09\u306f\u3001\u52a0\u9f62\u76ae\u819a\u3067\u306f\u6c17\u6e29\u30fb\u6e7f\u5ea6\u4f4e\u4e0b\u306b\u3088\u308a\u30d0\u30ea\u30a2\u56de\u5fa9\u901f\u5ea6\u304c\u8457\u3057\u304f\u9045\u308c\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u3066\u304a\u308a\u3001\u3068\u308d\u307f\u306e\u3042\u308b\u5316\u7ca7\u6c34\uff0b\u30af\u30ea\u30fc\u30e0\u3067\u306e\u6c34\u5206\u5bc6\u5c01\u304c\u6709\u52b9\u3067\u3059\u3002<\/p>\n<p>\u540c\u3058\u88fd\u54c1\u3092\u4e00\u5e74\u4e2d\u4f7f\u3046\u306e\u3067\u306f\u306a\u304f\u3001\u5b63\u7bc0\u306b\u5fdc\u3058\u305f\u51e6\u65b9\u3092\u5207\u308a\u66ff\u3048\u308b\u3053\u3068\u304c\u300150\u4ee3\u306e\u808c\u306b\u5fc5\u8981\u306a\u67d4\u8edf\u6027\u3068\u3044\u3048\u307e\u3059\u3002<\/p>\n<p>\u306a\u304a\u3001\u5316\u7ca7\u6c34\u306e\u30c6\u30af\u30b9\u30c1\u30e3\u30fc\u3068\u4fdd\u6e7f\u52b9\u679c\u306b\u5fc5\u305a\u3057\u3082\u56e0\u679c\u95a2\u4fc2\u306f\u306a\u304f\u3001\u3055\u3063\u3071\u308a\u30bf\u30a4\u30d7\u304c\u3068\u308d\u307f\u30bf\u30a4\u30d7\u3088\u308a\u4fdd\u6e7f\u529b\u304c\u4f4e\u3044\u3068\u306f\u9650\u308a\u307e\u305b\u3093\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\uff1c\u53c2\u8003\u8a18\u4e8b\uff1e<\/p>\n<p><a href=\"https:\/\/www.nahls.co.jp\/eijingukea\/cosmetics\/keshousui\/natu-osususme\/\" target=\"_blank\" rel=\"noopener\" data-nodal=\"\">\u590f\u306e\u30c0\u30e1\u30fc\u30b8\u3092\u9632\u3050\uff01\u304a\u3059\u3059\u3081\u306e\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u5316\u7ca7\u6c3420\u9078\u3092\u5fb9\u5e95\u89e3\u8aac\uff01<\/a><\/p>\n<p><a href=\"https:\/\/www.nahls.co.jp\/eijingukea\/cosmetics\/keshousui\/aki-keshousui\/\" target=\"_blank\" rel=\"noopener\" data-nodal=\"\">\u79cb\u306e\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u306f\u5316\u7ca7\u6c34\u3067\uff01\u304a\u3059\u3059\u3081\u306e\u5316\u7ca7\u6c3420\u9078\u3092\u7d39\u4ecb\uff01<\/a><\/p>\n<p><a href=\"https:\/\/www.nahls.co.jp\/eijingukea\/cosmetics\/keshousui\/huyu-osusume\/\" target=\"_blank\" rel=\"noopener\" data-nodal=\"\">\u51ac\u306b\u30d4\u30c3\u30bf\u30ea\uff01\u6700\u5f37\u4fdd\u6e7f\uff06\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u3092\u53f6\u3048\u308b\u304a\u3059\u3059\u3081\u5316\u7ca7\u6c3420\u9078<\/a><\/p>\n<h3>2\uff09 \u66f4\u5e74\u671f\u30fb\u9589\u7d4c\u524d\u5f8c\u306e\u3086\u3089\u304e\u808c\u5bfe\u5fdc<\/h3>\n<p>\u66f4\u5e74\u671f\u3084\u9589\u7d4c\u524d\u5f8c\u306f\u3001\u5973\u6027\u30db\u30eb\u30e2\u30f3\u306e\u6e1b\u5c11\u306b\u3088\u308a\u76ae\u8102\u5206\u6ccc\u3068\u30b3\u30e9\u30fc\u30b2\u30f3\u7523\u751f\u304c\u4f4e\u4e0b\u3057\u3001\u808c\u306e\u4e7e\u71e5\u30fb\u304f\u3059\u307f\u30fb\u307b\u3066\u308a\u304c\u51fa\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>Farage et al. (2022\uff09\u306f\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u4f4e\u4e0b\u304c\u771f\u76ae\u7dda\u7dad\u82bd\u7d30\u80de\u306e\u4ee3\u8b1d\u3092\u6291\u3048\u3001\u76ae\u819a\u306e\u539a\u307f\u3068\u6c34\u5206\u91cf\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3068\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u3053\u306e\u6642\u671f\u306f\u3001\u300c\u93ae\u9759\u300d\u3068\u300c\u30d0\u30ea\u30a2\u56de\u5fa9\u300d\u3092\u540c\u6642\u306b\u610f\u8b58\u3057\u305f\u5316\u7ca7\u6c34\u30b1\u30a2\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n<p>\u304a\u3059\u3059\u3081\u306f\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u30d5\u30ea\u30fc\u30fb\u5f31\u9178\u6027\u30fb\u30bb\u30e9\u30df\u30c9\u3084\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u914d\u5408\u30bf\u30a4\u30d7\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u307b\u3066\u308a\u304c\u5f37\u3044\u6642\u671f\u306f\u30b0\u30ea\u30c1\u30eb\u30ea\u30c1\u30f3\u91782K\u3084CICA(\u30b7\u30ab)\u306a\u3069\u914d\u5408\u306e\u5316\u7ca7\u6c34\u3092\u30cf\u30f3\u30c9\u30d7\u30ec\u30b9\u3067\u3086\u3063\u304f\u308a\u306a\u3058\u307e\u305b\u308b\u3068\u708e\u75c7\u3092\u6291\u3048\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>\u307e\u305f\u3001\u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\u306a\u3069\u306e\u30a2\u30df\u30ce\u9178\u8a98\u5c0e\u4f53\u306f\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u6291\u3048\u3064\u3064\u7dda\u7dad\u82bd\u7d30\u80de\u306e\u6d3b\u6027\u3092\u7dad\u6301\u3059\u308b\u4f5c\u7528\u304c\u3042\u308a\u3001\u66f4\u5e74\u671f\u808c\u306e\u3086\u3089\u304e\u5bfe\u7b56\u3068\u3057\u3066\u7406\u8ad6\u7684\u306b\u9069\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\uff1c\u53c2\u8003\u8a18\u4e8b\uff1e<\/p>\n<p><a href=\"https:\/\/www.nahls.co.jp\/eijingukea\/mechanism\/jyosei-horumon\/joseihorumonn-kounennki\/\" target=\"_blank\" rel=\"noopener\" data-nodal=\"\">\u5973\u6027\u30db\u30eb\u30e2\u30f3\u306e\u306f\u305f\u3089\u304d\u3092\u77e5\u3063\u3066\u66f4\u5e74\u671f\u5bfe\u7b56\u3068\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\uff01<\/a><\/p>\n<h3>3\uff09 \u7761\u7720\u30fb\u7d2b\u5916\u7dda\u30fb\u98df\u4e8b\u3068\u5316\u7ca7\u6c34\u52b9\u679c\u306e\u95a2\u4fc2<\/h3>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-112 size-full\" src=\"\/eijingukea\/wp-content\/uploads\/2015\/06\/6d5211bfde5a6797f86fd53470fb2794-e1587382964258.jpg\" alt=\"\u7761\u7720\u3092\u3068\u308b\u5973\u6027\" width=\"424\" height=\"283\" \/><\/p>\n<p>\u751f\u6d3b\u7fd2\u6163\u306f\u3001\u5316\u7ca7\u6c34\u306e\u52b9\u679c\u306b\u3082\u5bc6\u63a5\u306b\u95a2\u308f\u308a\u307e\u3059\u3002<\/p>\n<p>\u7761\u7720\u4e0d\u8db3\u306f\u6210\u9577\u30db\u30eb\u30e2\u30f3\u5206\u6ccc\u3092\u6e1b\u3089\u3057\u3001\u89d2\u8cea\u7d30\u80de\u306e\u518d\u751f\u3092\u9045\u3089\u305b\u307e\u3059\u3002<\/p>\n<p>\u591c\u306e\u30b9\u30ad\u30f3\u30b1\u30a2\u5f8c\u306b\u3057\u3063\u304b\u308a\u7761\u7720\u3092\u3068\u308b\u3053\u3068\u306f\u3001\u6210\u5206\u306e\u6d78\u900f\uff08\u89d2\u8cea\u5c64\u307e\u3067\uff09\u3068\u4fee\u5fa9\u30b5\u30a4\u30af\u30eb\u306e\u540c\u8abf\u306b\u6709\u52b9\u3067\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u7d2b\u5916\u7dda\u3082\u3001\u89d2\u5c64\u306e\u8102\u8cea\u69cb\u9020\u3092\u9178\u5316\u3055\u305bTEWL\u3092\u4e0a\u6607\u3055\u305b\u308b\u4e3b\u56e0\u306e\u3072\u3068\u3064\u3067\u3059\u3002<\/p>\n<p>\u65e5\u4e2d\u306eUV\u5bfe\u7b56\u3092\u6020\u308b\u3068\u3001\u3044\u304f\u3089\u5316\u7ca7\u6c34\u3067\u4fdd\u6e7f\u3057\u3066\u3082\u52b9\u679c\u304c\u6301\u7d9a\u3057\u306b\u304f\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>\u307e\u305f\u3001Sj\u00f6berg et al. (2025\uff09\u306e\u5831\u544a\u3067\u306f\u3001\u30d3\u30bf\u30df\u30f3B\u7fa4\u3084\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u306e\u6442\u53d6\u304c\u76ae\u819a\u306e\u8102\u8cea\u30d0\u30e9\u30f3\u30b9\u3092\u6539\u5584\u3057\u3001\u5916\u7528\u4fdd\u6e7f\u5264\u3068\u306e\u76f8\u4e57\u52b9\u679c\u3092\u793a\u3059\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u3064\u307e\u308a\u3001\u98df\u4e8b\u30fb\u7761\u7720\u30fb\u7d2b\u5916\u7dda\u30b1\u30a2\u306e3\u8ef8\u3092\u6574\u3048\u308b\u3053\u3068\u3053\u305d\u304c\u3001\u5316\u7ca7\u6c34\u306e\u52b9\u679c\u3092\u6700\u5927\u5316\u3059\u308b\u300c\u5185\u5916\u30c0\u30d6\u30eb\u4fdd\u6e7f\u300d\u3067\u3059\u3002<\/p>\n<p>\u300c\u4f7f\u3044\u65b9\u300d\u3068\u300c\u751f\u6d3b\u7fd2\u6163\u300d\u3092\u4e21\u7acb\u3055\u305b\u308b\u3053\u3068\u304c\u300150\u4ee3\u306e\u808c\u3092\u9577\u671f\u7684\u306b\u5065\u3084\u304b\u306b\u4fdd\u3064\u9375\u3068\u3044\u3048\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<table>\n<tbody>\n<tr>\n<td width=\"566\"><strong>\uff1c\u76e3\u4fee\u8005\u30b3\u30e1\u30f3\u30c8\uff1e<\/strong><\/p>\n<p>\u5b63\u7bc0\u30fb\u30db\u30eb\u30e2\u30f3\u30fb\u751f\u6d3b\u7fd2\u6163\u306b\u3088\u3063\u3066\u808c\u306e\u72b6\u614b\u306f\u7d76\u3048\u305a\u5909\u5316\u3057\u307e\u3059\u3002<\/p>\n<p>\u5316\u7ca7\u6c34\u3092\u201c\u56fa\u5b9a\u5316\u201d\u305b\u305a\u3001\u808c\u306e\u58f0\u3092\u805e\u304d\u306a\u304c\u3089\u9078\u3073\u65b9\u3068\u4f7f\u3044\u65b9\u3092\u8abf\u6574\u3059\u308b\u3053\u3068\u304c\u300150\u4ee3\u306e\u30b9\u30ad\u30f3\u30b1\u30a2\u6210\u529f\u306e\u79d8\u8a23\u3067\u3059\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\uff1c\u53c2\u7167\u8ad6\u6587\uff1e<\/strong><\/p>\n<p>1.Farage MA, et al. <em>Updated Perspectives on the Role of Estrogens in Skin Aging.<\/em> <em>Clin Cosmet Investig Dermatol.<\/em> 2022;15:2111\u20132124. doi:10.2147\/CCID.S387833<\/p>\n<p>URL: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36381976\/\" target=\"_blank\" rel=\"noopener\" data-nodal=\"\">https:\/\/pubmed.ncbi.nlm.nih.gov\/36381976\/<\/a><\/p>\n<p>\u8981\u65e8\uff08\u65e5\u672c\u8a9e\uff09\uff1a\u9589\u7d4c\u671f\u5973\u6027\u306e\u808c\u8001\u5316\u306b\u304a\u3051\u308b\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u4f4e\u4e0b\u306e\u5f71\u97ff\u3092\u7dcf\u8aac\u3002\u7dda\u7dad\u82bd\u7d30\u80de\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3068\u76ae\u8102\u5206\u6ccc\u6e1b\u5c11\u3092\u78ba\u8a8d\u3002<\/p>\n<p>2.Bar O, et al. <em>Physicochemical factors governing skin penetration and barrier recovery in aging skin.<\/em> <em>Cosmetics.<\/em> 2025;12(4\uff09:129. doi:10.3390\/cosmetics1204129<\/p>\n<p>URL: <a href=\"https:\/\/www.mdpi.com\/2079-9284\/12\/4\/129\" target=\"_blank\" rel=\"noopener\" nodal=\"\" class=\"broken_link\">https:\/\/www.mdpi.com\/2079-9284\/12\/4\/129<\/a><\/p>\n<p>\u8981\u65e8\uff08\u65e5\u672c\u8a9e\uff09\uff1a\u52a0\u9f62\u76ae\u819a\u3067\u306f\u4f4e\u6e7f\u5ea6\u4e0b\u3067\u306e\u30d0\u30ea\u30a2\u56de\u5fa9\u304c\u9045\u5ef6\u3002\u5916\u6c17\u6e29\u30fb\u6e7f\u5ea6\u3068\u5316\u7ca7\u54c1\u6d78\u900f\u6027\u306e\u95a2\u9023\u3092\u89e3\u8aac\u3002<\/p>\n<p>3.Sj\u00f6berg T, et al. <em>Niacinamide and its impact on stratum corneum hydration and lipid matrix organization.<\/em> <em>Sci Rep.<\/em> 2025;15:88899. doi:10.1038\/s41598-025-88899-0<\/p>\n<p>URL: <a href=\"https:\/\/www.nature.com\/articles\/s41598-025-88899-0\" target=\"_blank\" rel=\"noopener\" data-nodal=\"\">https:\/\/www.nature.com\/articles\/s41598-025-88899-0<\/a><\/p>\n<p>\u8981\u65e8\uff08\u65e5\u672c\u8a9e\uff09\uff1a\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u304c\u89d2\u5c64\u8102\u8cea\u69cb\u9020\u3092\u6574\u3048\u3001\u6c34\u5206\u4fdd\u6301\u30fb\u8102\u8cea\u4ee3\u8b1d\u30fb\u98df\u4e8b\u6804\u990a\u3068\u306e\u76f8\u95a2\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3002<\/p>\n<h2 class=\"md2\">6.50\u4ee3\u306b\u304a\u3059\u3059\u3081\u306e\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u5316\u7ca7\u6c34\u300c\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u300d\u306e\u4f7f\u3044<\/h2>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-76058 size-large\" src=\"\/eijingukea\/wp-content\/uploads\/2025\/11\/f13bf89f82dcb076eac889bd864f5545-1024x384.jpg\" alt=\"50\u4ee3\u306b\u304a\u3059\u3059\u3081\u306e\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u5316\u7ca7\u6c34\u300c\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u300d\" width=\"1024\" height=\"384\" \/><\/p>\n<h3>1\uff09\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u3068\u306f\uff1f<\/h3>\n<p>50\u4ee3\u306e\u808c\u306b\u304a\u3059\u3059\u3081\u3057\u305f\u3044\u306e\u304c\u3001\u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\u914d\u5408\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u30ed\u30fc\u30b7\u30e7\u30f3\u300c\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u300d\u3067\u3059\u3002<\/p>\n<p>\u808c\u306e\u30cf\u30ea\u30fb\u5f3e\u529b\u3092\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\u3092\u306f\u3058\u3081\u3001\u8907\u5408\u7684\u306a\u5e74\u9f62\u808c\u306e\u60a9\u307f\u306b\u5bfe\u5fdc\u3059\u308b\u9ad8\u6a5f\u80fd\u51e6\u65b9\u304c\u7279\u9577\u3067\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u306f\u3001\u4e7e\u71e5\u30fb\u3057\u308f\u30fb\u307b\u3046\u308c\u3044\u7dda\u30fb\u305f\u308b\u307f\u6bdb\u7a74\u306a\u3069\u304c\u6c17\u306b\u306a\u308b50\u4ee3\u306e\u808c\u306b\u3074\u3063\u305f\u308a\u3002<\/p>\n<p>\u4e7e\u71e5\u5bfe\u7b56\u3060\u3051\u3067\u306a\u304f\u3001\u30cf\u30ea\u3084\u30c4\u30e4\u3092\u53d6\u308a\u623b\u3057\u305f\u3044\u65b9\u3001\u808c\u306e\u63fa\u3089\u304e\u3092\u611f\u3058\u3084\u3059\u3044\u654f\u611f\u808c\u306e\u65b9\u306b\u3082\u5e45\u5e83\u304f\u4f7f\u3063\u3066\u3044\u305f\u3060\u3051\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/www.nahls.co.jp\/Landing\/Formlp\/pure.aspx?utm_campaign=pure&amp;utm_medium=referral&amp;utm_source=50%E4%BB%A3%E3%81%AE%E3%82%A8%E3%82%A4%E3%82%B8%E3%83%B3%E3%82%B0%E3%82%B1%E3%82%A2%E5%8C%96%E7%B2%A7%E6%B0%B4%E3%81%AF%E5%84%AA%E3%81%97%E3%81%84%E3%81%AE%E3%81%8C%E3%81%8A%E3%81%99%E3%81%99%E3%82%81%EF%BC%81%E9%81%B8%E3%81%B3%E6%96%B9%E3%81%A8%E4%BD%BF%E3%81%84%E6%96%B9-pure-1\" target=\"_blank\" rel=\"noopener\" data-nodal=\"\"><strong>\u30ca\u30fc\u30eb\u30b9\u30b2\u30f3\u914d\u5408\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u30ed\u30fc\u30b7\u30e7\u30f3\u300c\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u300d<\/strong><\/a><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-42927 size-full\" src=\"\/eijingukea\/wp-content\/uploads\/2020\/10\/79a9e96b71dcf37d293f9d9f2c718b69-e1603743327906.png\" alt=\"50\u4ee3\u306b\u304a\u3059\u3059\u3081\u306e\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u5316\u7ca7\u6c34\u300c\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u300d\" width=\"400\" height=\"263\" \/><\/p>\n<p>\u521d\u56de\u9650\u5b9a\u4fa1\u683c\uff014,950\u5186 \u2192 3,465\u5186\uff08\u7a0e\u8fbc\uff09<\/p>\n<h3>2\uff09\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u306e\u4f7f\u3044\u65b9<\/h3>\n<p class=\"md2\"><strong>\u2460500\u5186\u7389\u5927\u306e\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u3092\u624b\u306e\u3072\u3089\u306b\u3068\u308a\u307e\u3059\u3002<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-76098 size-full\" src=\"\/eijingukea\/wp-content\/uploads\/2025\/11\/392422411568c16245f955e182e847bb.jpg\" alt=\"\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u3092\u624b\u306b\u53d6\u308b\u69d8\u5b50\" width=\"145\" height=\"135\" \/><\/p>\n<p class=\"md2\"><strong>\u2461\u982c\u30fb\u76ee\u5143\u30fb\u53e3\u5143\u306a\u3069\u3001\u4e7e\u71e5\u3092\u611f\u3058\u308b\u90e8\u5206\u304b\u3089\u201c\u3053\u3059\u3089\u305a\u30fb\u624b\u306e\u3072\u3089\u3067\u5305\u3080\u3088\u3046\u306b\u30cf\u30f3\u30c9\u30d7\u30ec\u30b9\u201d\u3057\u306a\u304c\u3089\u306a\u3058\u307e\u305b\u307e\u3059\u3002<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-76099 size-full\" src=\"\/eijingukea\/wp-content\/uploads\/2025\/11\/1534e1330ff042bd69a59ded7117e3ad.jpg\" alt=\"\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u3092\u5857\u308b\u5973\u6027\" width=\"145\" height=\"135\" \/><\/p>\n<p class=\"md2\"><strong>\u2462\u9854\u5168\u4f53\u306b\u5e83\u3052\u305f\u5f8c\u3001\u9996\u30fb\u30d5\u30a7\u30a4\u30b9\u30e9\u30a4\u30f3\u30fb\u30c7\u30b3\u30eb\u30c6\u307e\u3067\u5fd8\u308c\u305a\u306b\u30cf\u30f3\u30c9\u30d7\u30ec\u30b9\u300250\u4ee3\u306e\u808c\u306f\u9854\u4ee5\u5916\u306b\u3082\u6c34\u5206\u4fdd\u6301\u529b\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u307e\u3059\u306e\u3067\u3001\u4e0b\u65b9\u5411\u306b\u610f\u8b58\u3057\u3066\u306a\u3058\u307e\u305b\u307e\u3057\u3087\u3046\u3002<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p>\u5b63\u7bc0\u3084\u808c\u72b6\u614b\u306b\u5fdc\u3058\u3066\u8cea\u611f\u3092\u9078\u3073\u3001\u5165\u6d74\u5f8c\u3084\u591c\u306e\u30b1\u30a2\u3067\u306f\u5c11\u3057\u591a\u3081\u306b\u4f7f\u7528\u3057\u3066\u201c\u4fdd\u6e7f\u30e2\u30fc\u30c9\u201d\u3092\u9ad8\u3081\u308b\u306e\u3082\u304a\u3059\u3059\u3081\u3067\u3059\u3002<\/p>\n<p>\u4f7f\u7528\u5f8c\u306f\u3001\u7f8e\u5bb9\u6db2\u30fb\u30af\u30ea\u30fc\u30e0\u3067\u201c\u91cd\u306d\u4fdd\u8b77\u201d\u3092\u3059\u308b\u3068\u3001\u5316\u7ca7\u6c34\u306e\u6d78\u900f\uff08\u89d2\u8cea\u5c64\u307e\u3067\uff09\u3068\u6301\u7d9a\u52b9\u679c\u304c\u9ad8\u307e\u308a\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<table>\n<tbody>\n<tr>\n<td width=\"566\"><strong>\uff1c\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u76e3\u4fee\u533b\uff08\u5742\u4e95\u4e07\u91cc\u5148\u751f\uff09\u30b3\u30e1\u30f3\u30c8\uff1e<\/strong><\/p>\n<p>\u30ca\u30fc\u30eb\u30b9 \u30d4\u30e5\u30a2\u306e\u3088\u3046\u306a\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u5316\u7ca7\u6c34\u309250\u4ee3\u306e\u808c\u306b\u201c\u4f7f\u3044\u65b9\u307e\u3067\u610f\u8b58\u3057\u3066\u4f7f\u3046\u201d\u3053\u3068\u3067\u3001\u6210\u5206\u304c\u89d2\u8cea\u5c64\u307e\u3067\u5c4a\u304d\u3084\u3059\u304f\u306a\u308a\u3001\u6c34\u5206\u4fdd\u6301\u3068\u30d0\u30ea\u30a2\u518d\u751f\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002\u5b63\u7bc0\u30fb\u4f53\u8abf\u30fb\u751f\u6d3b\u7fd2\u6163\u306b\u5fdc\u3058\u3066\u67d4\u8edf\u306b\u4f7f\u3044\u5206\u3051\u307e\u3057\u3087\u3046\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p>\uff1c\u53c2\u8003\u8a18\u4e8b\uff1e<\/p>\n<p><a href=\"https:\/\/www.nahls.co.jp\/hpgen\/HPB\/entries\/4.aspx\" target=\"_blank\" rel=\"noopener\" data-nodal=\"\">\u30ca\u30fc\u30eb\u30b9\u306e\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u5316\u7ca7\u54c1\u306e\u4f7f\u3044\u65b9<\/a><\/p>\n<h2 class=\"md2\">7.\u7f8e\u5bb9\u6db2\u30fb\u30af\u30ea\u30fc\u30e0\u3068\u306e\u91cd\u306d\u4f7f\u3044\u3067\u76f8\u4e57\u52b9\u679c<\/h2>\n<p>\u5316\u7ca7\u6c34\u3067\u3046\u308b\u304a\u3044\u3092\u4e0e\u3048\u305f\u3042\u3068\u306f\u3001\u7f8e\u5bb9\u6db2\u3068\u30af\u30ea\u30fc\u30e0\u3067\u6c34\u5206\u3092\u300c\u5b88\u308a\u30fb\u80b2\u3066\u308b\u300d\u30b9\u30c6\u30c3\u30d7\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n<p>50\u4ee3\u3067\u306f\u89d2\u8cea\u5c64\u306e\u8102\u8cea\u91cf\u304c\u6e1b\u308a\u3001\u808c\u304c\u6c34\u5206\u3092\u4fdd\u3064\u529b\u304c\u8870\u3048\u308b\u305f\u3081\u3001\u5916\u5074\u304b\u3089\u306e\u201c\u91cd\u306d\u4fdd\u6e7f\u201d\u304c\u5fc5\u8981\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>\u3053\u3053\u3067\u306f\u3001\u79d1\u5b66\u7684\u6839\u62e0\u306b\u57fa\u3065\u304f\u91cd\u306d\u4f7f\u3044\u306e\u30b3\u30c4\u3092\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n<h3>1\uff09 \u30bb\u30e9\u30df\u30c9\u7f8e\u5bb9\u6db2\u3067\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u9ad8\u3081\u308b<\/h3>\n<p>\u30bb\u30e9\u30df\u30c9\u306f\u89d2\u8cea\u5c64\u306e\u7d30\u80de\u9593\u8102\u8cea\u306e\u4e3b\u6210\u5206\u3067\u3042\u308a\u3001\u30d0\u30ea\u30a2\u6a5f\u80fd\u3068\u6c34\u5206\u4fdd\u6301\u306e\u8981\u3067\u3059\u3002<\/p>\n<p>Spada et al. (2018\uff09\u306f\u3001\u30bb\u30e9\u30df\u30c9\u914d\u5408\u4fdd\u6e7f\u5264\u306e\u5916\u7528\u3067\u89d2\u5c64\u6c34\u5206\u91cf\u304c\u5897\u52a0\u3057\u3001TEWL\uff08\u7d4c\u8868\u76ae\u6c34\u5206\u84b8\u6563\u91cf\uff09\u304c\u6709\u610f\u306b\u6e1b\u5c11\u3059\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u5316\u7ca7\u6c34\u5f8c\u306b\u30d2\u30c8\u578b\u30bb\u30e9\u30df\u30c9\uff08\u30bb\u30e9\u30df\u30c9NP\u3001AP\u306a\u3069\uff09\u3092\u542b\u3080\u30ca\u30fc\u30eb\u30b9\u30cd\u30aa\u306a\u3069\u306e\u7f8e\u5bb9\u6db2\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u89d2\u5c64\u5185\u306e\u30e9\u30e1\u30e9\u69cb\u9020\u3092\u88dc\u5f37\u3057\u3001\u4e7e\u71e5\u3084\u523a\u6fc0\u3078\u306e\u8010\u6027\u3092\u9ad8\u3081\u3089\u308c\u307e\u3059\u3002<\/p>\n<p>\u30bb\u30e9\u30df\u30c9\u7f8e\u5bb9\u6db2\u306f\u3001\u3068\u308d\u307f\u306e\u5c11\u306a\u3044\u8efd\u3044\u30c6\u30af\u30b9\u30c1\u30e3\u30fc\u3092\u5c11\u91cf\u305a\u3064\u30cf\u30f3\u30c9\u30d7\u30ec\u30b9\u3059\u308b\u306e\u304c\u7406\u60f3\u3067\u3059\u3002<\/p>\n<h3>2\uff09 \u30bb\u30e9\u30df\u30c9\u30af\u30ea\u30fc\u30e0\u3082\u304a\u3059\u3059\u3081<\/h3>\n<p>\u7f8e\u5bb9\u6db2\u3067\u3046\u308b\u304a\u3044\u3092\u4e0e\u3048\u305f\u5f8c\u306f\u3001\u30bb\u30e9\u30df\u30c9\u3084\u30b7\u30a2\u30d0\u30bf\u30fc\u3092\u542b\u3080\u300c\u30ca\u30fc\u30eb\u30b9\u30e6\u30cb\u30d0\u300d\u306a\u3069\u306e\u4fdd\u6e7f\u30af\u30ea\u30fc\u30e0\u3067\u6cb9\u5206\u306e\u819c\u3092\u4f5c\u308a\u3001\u6c34\u5206\u84b8\u6563\u3092\u9632\u304e\u307e\u3059\u3002<\/p>\n<p>Bar et al. (2025\uff09\u306f\u3001\u52a0\u9f62\u76ae\u819a\u3067\u306f\u8102\u8cea\u30d0\u30ea\u30a2\u306e\u518d\u69cb\u7bc9\u306b\u6642\u9593\u304c\u304b\u304b\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u304a\u308a\u3001\u6c34\u5206\uff0b\u8102\u8cea\u306e\u4e8c\u91cd\u88dc\u7d66\u304c\u4e0d\u53ef\u6b20\u3067\u3042\u308b\u3068\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u7279\u306b\u5165\u6d74\u5f8c\u3084\u5c31\u5bdd\u524d\u306f\u3001\u89d2\u8cea\u304c\u67d4\u3089\u304b\u304f\u306a\u3063\u3066\u304a\u308a\u3001\u30bb\u30e9\u30df\u30c9\u30af\u30ea\u30fc\u30e0\u306e\u6210\u5206\u304c\u89d2\u5c64\u306b\u5747\u4e00\u306b\u5e83\u304c\u308a\u3084\u3059\u3044\u30bf\u30a4\u30df\u30f3\u30b0\u3067\u3059\u3002<\/p>\n<p>\u4e7e\u71e5\u304c\u5f37\u3044\u5b63\u7bc0\u3084\u76ee\u5143\u30fb\u53e3\u5143\u306b\u306f\u3001\u91cd\u306d\u5857\u308a\uff08\u30ea\u30d4\u30fc\u30c8\u4fdd\u6e7f\uff09\u3082\u304a\u3059\u3059\u3081\u3067\u3059\u3002<\/p>\n<h3>3\uff09 \u30ef\u30bb\u30ea\u30f3\u3084\u30b9\u30af\u30ef\u30e9\u30f3\u30aa\u30a4\u30eb\u3068\u306e\u4f75\u7528\u3082<\/h3>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-76088 size-medium\" src=\"\/eijingukea\/wp-content\/uploads\/2025\/11\/vaseline_image-300x200.jpg\" alt=\"\u30ef\u30bb\u30ea\u30f3\" width=\"300\" height=\"200\" \/><\/p>\n<p>\u808c\u304c\u6975\u5ea6\u306b\u4e7e\u71e5\u3057\u3066\u3044\u308b\u3068\u304d\u306f\u3001\u30ef\u30bb\u30ea\u30f3\u3084\u30b9\u30af\u30ef\u30e9\u30f3\u30aa\u30a4\u30eb\u3001\u30a2\u30eb\u30ac\u30f3\u30aa\u30a4\u30eb\u306a\u3069\u3067\u76ae\u8102\u819c\u3092\u4eba\u5de5\u7684\u306b\u88dc\u3046\u306e\u3082\u6709\u52b9\u3067\u3059\u3002<\/p>\n<p>\u3053\u308c\u3089\u306f\u6210\u5206\u7684\u306b\u9178\u5316\u3057\u306b\u304f\u304f\u3001\u808c\u8868\u9762\u306b\u300c\u4fdd\u8b77\u30d5\u30a3\u30eb\u30e0\u300d\u3092\u5f62\u6210\u3057\u3066\u5916\u7684\u523a\u6fc0\u304b\u3089\u5b88\u308a\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u7279\u306b\u3001\u82b1\u7c89\u30fb\u5bd2\u98a8\u30fb\u7d2b\u5916\u7dda\u306a\u3069\u306b\u3088\u308b\u523a\u6fc0\u3092\u53d7\u3051\u3084\u3059\u3044\u6642\u671f\u306b\u306f\u3001\u5316\u7ca7\u6c34\u2192\u7f8e\u5bb9\u6db2\u2192\u30ef\u30bb\u30ea\u30f3\u3084\u7f8e\u5bb9\u30aa\u30a4\u30eb\u306a\u3069\u306e\u9806\u3067\u4f7f\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u6301\u7d9a\u7684\u306a\u3046\u308b\u304a\u3044\u3092\u30ad\u30fc\u30d7\u3067\u304d\u307e\u3059\u3002<\/p>\n<p>\u305f\u3060\u3057\u3001\u76ae\u8102\u306e\u591a\u3044\u90e8\u4f4d\u3067\u306f\u6bdb\u7a74\u8a70\u307e\u308a\u306e\u539f\u56e0\u306b\u306a\u308b\u3053\u3068\u3082\u3042\u308b\u305f\u3081\u3001\u90e8\u5206\u4f7f\u3044\u3092\u610f\u8b58\u3057\u307e\u3057\u3087\u3046\u3002<\/p>\n<h3>4\uff09 \u808c\u518d\u751f\u3092\u76ee\u6307\u3059\u306a\u3089\u30ec\u30c1\u30ce\u30fc\u30eb\u7f8e\u5bb9\u6db2\u3084\u30ec\u30c1\u30ce\u30fc\u30eb\u30af\u30ea\u30fc\u30e0\u3082\u4f7f\u3046<\/h3>\n<p>\u30ec\u30c1\u30ce\u30fc\u30eb\uff08\u30d3\u30bf\u30df\u30f3A\u8a98\u5c0e\u4f53\uff09\u306f\u3001\u7dda\u7dad\u82bd\u7d30\u80de\u306e\u30b3\u30e9\u30fc\u30b2\u30f3\u7523\u751f\u3092\u4fc3\u9032\u3057\u3001\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u3092\u6574\u3048\u308b\u4f5c\u7528\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>Zasada et al. (2024\uff09\u306e\u7814\u7a76\u3067\u306f\u30010.1\u301c0.3\uff05\u6fc3\u5ea6\u306e\u30ec\u30c1\u30ce\u30fc\u30eb\u5916\u7528\u306b\u3088\u308a\u3001\u8868\u76ae\u539a\u306e\u5897\u52a0\u3068\u30b7\u30ef\u6539\u5584\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u305f\u3060\u3057\u3001\u521d\u671f\u523a\u6fc0\uff08\u30ec\u30c1\u30ce\u30a4\u30c9\u53cd\u5fdc\u5fdc:\u8d64\u307f\u30fb\u76ae\u3080\u3051\u306a\u3069\uff09\u3092\u907f\u3051\u308b\u305f\u3081\u3001\u90312\u301c3\u56de\u304b\u3089\u306e\u591c\u9593\u4f7f\u7528\u304c\u57fa\u672c\u3067\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u5316\u7ca7\u6c34\u3067\u89d2\u5c64\u3092\u6574\u3048\u305f\u3042\u3068\u306b\u30ec\u30c1\u30ce\u30fc\u30eb\u7f8e\u5bb9\u6db2\u2192\u30af\u30ea\u30fc\u30e0\u306e\u9806\u3067\u5857\u5e03\u3059\u308b\u3068\u3001\u6210\u5206\u306e\u6d78\u900f\u52b9\u7387\u3068\u5b89\u5b9a\u6027\u304c\u9ad8\u307e\u308a\u307e\u3059\u3002<\/p>\n<p>\u65e5\u4e2d\u306f\u7d2b\u5916\u7dda\u611f\u53d7\u6027\u304c\u4e0a\u304c\u308b\u305f\u3081\u3001\u5fc5\u305aUV\u30b1\u30a2\u3092\u4f75\u7528\u3057\u307e\u3057\u3087\u3046\u3002<\/p>\n<p>\u7279\u306b50\u4ee3\u3067\u306f\u3001\u523a\u6fc0\u3092\u907f\u3051\u308b\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002<\/p>\n<h3>5\uff09 \u5316\u7ca7\u6c34\u2192\u7f8e\u5bb9\u6db2\u2192\u30af\u30ea\u30fc\u30e0\u306e\u6700\u9069\u306a\u30bf\u30a4\u30df\u30f3\u30b0<\/h3>\n<p>\u30b9\u30ad\u30f3\u30b1\u30a2\u306f\u3001\u9806\u756a\u3060\u3051\u3067\u306a\u304f\u300c\u6642\u9593\u5dee\u300d\u304c\u5927\u5207\u3067\u3059\u3002<\/p>\n<p>\u5316\u7ca7\u6c34\u5857\u5e03\u5f8c\u3001\u3059\u3050\u3067\u306f\u306a\u304f1\uff5e\u6570\u5206\u5f85\u3063\u3066\u7f8e\u5bb9\u6db2\u3092\u91cd\u306d\u308b\u3068\u6210\u5206\u62e1\u6563\u52b9\u7387\u304c\u6700\u5927\u5316\u3055\u308c\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u307e\u305f\u3001\u30af\u30ea\u30fc\u30e0\u3092\u5857\u308b\u307e\u3067\u306e\u9593\u9694\u30921\u301c2\u5206\u3042\u3051\u308b\u3053\u3068\u3067\u3001\u89d2\u5c64\u306b\u6c34\u5206\u304c\u5b9a\u7740\u3057\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>\u300c\u5857\u308b\u300d\u3067\u306f\u306a\u304f\u300c\u91cd\u306d\u3066\u80b2\u3066\u308b\u300d\u610f\u8b58\u304c\u3001\u3046\u308b\u304a\u3044\u306e\u6301\u7d9a\u3068\u808c\u518d\u751f\u529b\u306e\u9375\u3067\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<table>\n<tbody>\n<tr>\n<td width=\"566\"><strong>\uff1c\u76e3\u4fee\u8005\u30b3\u30e1\u30f3\u30c8\uff1e<\/strong><\/p>\n<p>\u5316\u7ca7\u6c34\u3060\u3051\u3067\u306f\u4fdd\u6e7f\u306f\u5b8c\u7d50\u3057\u307e\u305b\u3093\u3002<\/p>\n<p>\u7f8e\u5bb9\u6db2\u3067\u201c\u88dc\u3044\u201d\u3001\u30af\u30ea\u30fc\u30e0\u3067\u201c\u5b88\u308b\u201d\u3068\u3044\u3046\u4e8c\u6bb5\u69cb\u3048\u304c\u300150\u4ee3\u306e\u808c\u306e\u5f3e\u529b\u3068\u30c4\u30e4\u3092\u53d6\u308a\u623b\u3059\u6700\u77ed\u30eb\u30fc\u30c8\u3067\u3059\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p><strong>\uff1c\u53c2\u7167\u8ad6\u6587\uff1e<\/strong><\/p>\n<p>1.Spada F, et al. <em>Skin hydration is significantly increased by a ceramide-containing cream and correlates with a reduction in TEWL.<\/em> <em>Int J Cosmet Sci.<\/em> 2018; 40(2\uff09: 204-213. doi:10.1111\/ics.12463<\/p>\n<p>URL: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6197824\/?utm_source=chatgpt.com\" target=\"_blank\" rel=\"noopener\" data-nodal=\"\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6197824\/<\/a><\/p>\n<p>\u8981\u65e8\uff08\u65e5\u672c\u8a9e\uff09\uff1a\u30bb\u30e9\u30df\u30c9\u914d\u5408\u4fdd\u6e7f\u5264\u304c\u89d2\u5c64\u6c34\u5206\u91cf\u3092\u5897\u52a0\u3055\u305b\u3001TEWL\u3092\u6e1b\u5c11\u3002\u76ae\u819a\u30d0\u30ea\u30a2\u518d\u69cb\u7bc9\u306e\u6709\u52b9\u6027\u3092\u793a\u3057\u305f\u3002<\/p>\n<p>2.Bar O, et al. <em>Physicochemical factors governing skin penetration and barrier recovery in aging skin.<\/em> <em>Cosmetics.<\/em> 2025; 12(4\uff09: 129. doi:10.3390\/cosmetics1204129<\/p>\n<p>URL: <a href=\"https:\/\/www.mdpi.com\/2079-9284\/12\/4\/129\" target=\"_blank\" rel=\"noopener\" nodal=\"\" class=\"broken_link\">https:\/\/www.mdpi.com\/2079-9284\/12\/4\/129<\/a><\/p>\n<p>\u8981\u65e8\uff08\u65e5\u672c\u8a9e\uff09\uff1a\u52a0\u9f62\u76ae\u819a\u3067\u306f\u8102\u8cea\u518d\u751f\u304c\u9045\u308c\u3001\u5916\u7528\u30af\u30ea\u30fc\u30e0\u306b\u3088\u308b\u8102\u8cea\u88dc\u7d66\u304c\u30d0\u30ea\u30a2\u6a5f\u80fd\u7dad\u6301\u306b\u5bc4\u4e0e\u3059\u308b\u3053\u3068\u3092\u660e\u793a\u3002<\/p>\n<p>3.Sj\u00f6berg T, et al. <em>Niacinamide and its impact on stratum corneum hydration and lipid matrix organization.<\/em> <em>Sci Rep.<\/em> 2025; 15: 88899. doi:10.1038\/s41598-025-88899-0<\/p>\n<p>URL: <a href=\"https:\/\/www.nature.com\/articles\/s41598-025-88899-0\" target=\"_blank\" rel=\"noopener\" data-nodal=\"\">https:\/\/www.nature.com\/articles\/s41598-025-88899-0<\/a><\/p>\n<p>\u8981\u65e8\uff08\u65e5\u672c\u8a9e\uff09\uff1a\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u304c\u89d2\u5c64\u306e\u8102\u8cea\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u3092\u6574\u3048\u3001\u5316\u7ca7\u6c34\u5f8c\u306e\u4fdd\u6e7f\u5264\u5857\u5e03\u30bf\u30a4\u30df\u30f3\u30b0\u306b\u3088\u308b\u6c34\u5206\u52d5\u614b\u5909\u5316\u3092\u89e3\u6790\u3002<\/p>\n<p>4.Zasada M, et al. <em>Topical retinoids and their effect on skin aging and regeneration: a systematic review.<\/em> <em>Dermatol Ther.<\/em> 2024; 37(3\uff09: e16109. doi:10.1111\/dth.16109<\/p>\n<p>URL: https:\/\/pubmed.ncbi.nlm.nih.gov\/38671960\/<\/p>\n<p>\u8981\u65e8\uff08\u65e5\u672c\u8a9e\uff09\uff1a\u30ec\u30c1\u30ce\u30fc\u30eb\u5916\u7528\u306b\u3088\u308a\u8868\u76ae\u539a\u30fb\u30b3\u30e9\u30fc\u30b2\u30f3\u5bc6\u5ea6\u304c\u5897\u52a0\u3002\u4f4e\u6fc3\u5ea6\u304b\u3089\u306e\u6f38\u5897\u4f7f\u7528\u304c\u5b89\u5168\u3067\u6709\u52b9\u3068\u5831\u544a<strong>\u3002<\/strong><\/p>\n<h2 class=\"md2\">8.50\u4ee3\u306e\u5316\u7ca7\u6c34\u306e\u4f7f\u3044\u65b9\u306b\u95a2\u3059\u308b\u3088\u304f\u3042\u308b\u8cea\u554f<\/h2>\n<h3><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-13648 size-full\" src=\"\/eijingukea\/wp-content\/uploads\/2017\/11\/795316b92fc766b0181f6fef074f03fa.png\" alt=\"\u3088\u304f\u3042\u308b\u8cea\u554f\" width=\"350\" height=\"256\" \/><\/h3>\n<h3>Q1.\u5316\u7ca7\u6c34\u306f\u671d\u3068\u591c\u3067\u4f7f\u3044\u65b9\u3092\u5909\u3048\u305f\u307b\u3046\u304c\u3044\u3044\u3067\u3059\u304b\uff1f<\/h3>\n<p>\u5316\u7ca7\u6c34\u81ea\u4f53\u306e\u4f7f\u3044\u65b9\u3092\u5927\u304d\u304f\u5909\u3048\u308b\u5fc5\u8981\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u671d\u306f\u300c\u5b88\u308b\u4fdd\u6e7f\u300d\u3001\u591c\u306f\u300c\u6574\u3048\u308b\u4fdd\u6e7f\u300d\u3092\u610f\u8b58\u3057\u307e\u3057\u3087\u3046\u3002<\/p>\n<p>\u671d\u306f\u65e5\u4e2d\u306e\u7d2b\u5916\u7dda\u3084\u4e7e\u71e5\u306b\u5099\u3048\u3001\u5316\u7ca7\u6c34\uff0b\u7f8e\u5bb9\u6db2+\u4e73\u6db2\u307e\u305f\u306f\u30af\u30ea\u30fc\u30e0\u3067\u76ae\u8102\u819c\u3092\u88dc\u3044\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u591c\u306f\u89d2\u5c64\u306e\u4fee\u5fa9\u304c\u9032\u3080\u6642\u9593\u5e2f\u306e\u305f\u3081\u3001\u4fdd\u6e7f\u5316\u7ca7\u6c34\u3084\u7f8e\u5bb9\u6db2\u3092\u91cd\u306d\u3065\u3051\u3057\u3066\u3001\u808c\u306e\u518d\u751f\u3092\u30b5\u30dd\u30fc\u30c8\u3057\u307e\u3059\u3002<\/p>\n<p>\u591c\u306e\u30b1\u30a2\u5f8c\u306f\u3057\u3063\u304b\u308a\u7761\u7720\u3092\u3068\u308b\u3053\u3068\u3067\u3001\u6210\u5206\u5438\u53ce\uff08\u89d2\u8cea\u5c64\u307e\u3067\uff09\u3068\u4ee3\u8b1d\u306e\u540c\u8abf\u304c\u4fc3\u9032\u3055\u308c\u307e\u3059\u3002<\/p>\n<h3>Q2.\u30b3\u30c3\u30c8\u30f3\u3068\u624b\u3001\u3069\u3061\u3089\u304c\u3044\u3044\u3067\u3059\u304b\uff1f<\/h3>\n<p>\uff15\uff10\u4ee3\u306a\u3089\u57fa\u672c\u306f\u300c\u624b\u300d\u304c\u63a8\u5968\u3067\u3059\u3002<\/p>\n<p>\u30cf\u30f3\u30c9\u30d7\u30ec\u30b9\u3067\u3084\u3055\u3057\u304f\u306a\u3058\u307e\u305b\u308b\u3068\u3001\u6469\u64e6\u523a\u6fc0\u3092\u9632\u304e\u306a\u304c\u3089\u4f53\u6e29\u3067\u6d78\u900f\uff08\u89d2\u8cea\u5c64\u307e\u3067\uff09\u3092\u4fc3\u305b\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u305f\u3060\u3057\u3001\u62ed\u304d\u53d6\u308a\u5316\u7ca7\u6c34\u3084\u53ce\u6582\u5316\u7ca7\u6c34\u3092\u4f7f\u3046\u3068\u304d\u306e\u307f\u30b3\u30c3\u30c8\u30f3\u3092\u4f7f\u7528\u3057\u3001\u3053\u3059\u3089\u305a\u8efd\u304f\u62bc\u3055\u3048\u308b\u3088\u3046\u306b\u4f7f\u3044\u307e\u3057\u3087\u3046\u3002<\/p>\n<p>\u654f\u611f\u808c\u306e\u4eba\u306f\u3001\u30b3\u30c3\u30c8\u30f3\u306e\u7e4a\u7dad\u523a\u6fc0\u304c\u708e\u75c7\u3092\u8d77\u3053\u3059\u5834\u5408\u304c\u3042\u308b\u305f\u3081\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n<h3>Q3.\u5316\u7ca7\u6c34\u306e\u5f8c\u3001\u7f8e\u5bb9\u6db2\u3092\u4f7f\u3046\u30bf\u30a4\u30df\u30f3\u30b0\u306f\uff1f<\/h3>\n<p>\u5316\u7ca7\u6c34\u5857\u5e03\u5f8c\u30011\u301c2\u5206\u307b\u3069\u304a\u3044\u3066\u808c\u8868\u9762\u304c\u3057\u3063\u3068\u308a\u3057\u305f\u72b6\u614b\u3067\u7f8e\u5bb9\u6db2\u3092\u5857\u308b\u306e\u304c\u7406\u60f3\u3067\u3059\u3002<\/p>\n<p>\u5316\u7ca7\u6c34\u5f8c\u6570\u5206\u7a0b\u5ea6\u3067\u89d2\u5c64\u6c34\u5206\u91cf\u304c\u30d4\u30fc\u30af\u306b\u9054\u3059\u308b\u305f\u3081\u3001\uff15\u5206\u524d\u5f8c\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u3067\u7f8e\u5bb9\u6db2\u3092\u91cd\u306d\u308b\u3068\u52b9\u679c\u304c\u6700\u5927\u5316\u3057\u307e\u3059\u3002<\/p>\n<p>\u4e7e\u71e5\u304c\u5f37\u3044\u5834\u5408\u306f\u3001\u305d\u306e\u5f8c\u3059\u3050\u306b\u30af\u30ea\u30fc\u30e0\u3084\u30d0\u30fc\u30e0\u3067\u6c34\u5206\u3092\u9589\u3058\u8fbc\u3081\u307e\u3057\u3087\u3046\u3002<\/p>\n<h3>Q4.\u62ed\u304d\u53d6\u308a\u5316\u7ca7\u6c34\u3068\u4fdd\u6e7f\u5316\u7ca7\u6c34\u306f\u4f75\u7528\u3067\u304d\u307e\u3059\u304b\uff1f<\/h3>\n<p>\u306f\u3044\u3002\u305f\u3060\u3057\u3001\u90311\u301c2\u56de\u306e\u30b9\u30da\u30b7\u30e3\u30eb\u30b1\u30a2\u3068\u3057\u3066\u884c\u3046\u306e\u304c\u5b89\u5168\u3067\u3059\u3002<\/p>\n<p>\u307e\u305a\u62ed\u304d\u53d6\u308a\u5316\u7ca7\u6c34\u3067\u53e4\u3044\u89d2\u8cea\u3084\u76ae\u8102\u3092\u53d6\u308a\u9664\u304d\u3001\u305d\u306e\u5f8c\u306b\u4fdd\u6e7f\u5316\u7ca7\u6c34\u3092\u91cd\u306d\u3066\u6c34\u5206\u3092\u88dc\u3044\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u6bce\u65e5\u306e\u4f75\u7528\u306f\u89d2\u5c64\u3092\u50b7\u3081\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u305f\u3081\u907f\u3051\u307e\u3057\u3087\u3046\u3002<\/p>\n<p>\u7279\u306b50\u4ee3\u306e\u808c\u306f\u30bf\u30fc\u30f3\u30aa\u30fc\u30d0\u30fc\u304c\u9045\u3044\u305f\u3081\u3001\u300c\u843d\u3068\u3059\u30b1\u30a2\u300d\u3088\u308a\u3082\u300c\u5b88\u308b\u30b1\u30a2\u300d\u3092\u512a\u5148\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n<h3>Q5.\u654f\u611f\u808c\u3067\u3082\u4f7f\u3048\u308b\u304a\u3059\u3059\u3081\u306e\u4f7f\u3044\u65b9\u306f\uff1f<\/h3>\n<p>\u654f\u611f\u808c\u306e\u5834\u5408\u306f\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u30fb\u30e1\u30f3\u30c8\u30fc\u30eb\u30fb\u9999\u6599\u3092\u907f\u3051\u305f\u4f4e\u523a\u6fc0\u51e6\u65b9\u3092\u9078\u3076\u3053\u3068\u304c\u7b2c\u4e00\u3067\u3059\u3002<\/p>\n<p>Farage et al. (2022\uff09\u306f\u3001\u66f4\u5e74\u671f\u4ee5\u964d\u306e\u808c\u3067\u306f\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u4f4e\u4e0b\u306b\u3088\u308a\u5916\u7684\u523a\u6fc0\u3078\u306e\u611f\u53d7\u6027\u304c\u9ad8\u307e\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u305d\u306e\u305f\u3081\u3001\u30bb\u30e9\u30df\u30c9\u3084\u30ca\u30a4\u30a2\u30b7\u30f3\u30a2\u30df\u30c9\u3001\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\u306a\u3069\u3001\u808c\u30d0\u30ea\u30a2\u3092\u6574\u3048\u308b\u6210\u5206\u4e2d\u5fc3\u306e\u5316\u7ca7\u6c34\u3092\u9078\u3073\u3001\u30cf\u30f3\u30c9\u30d7\u30ec\u30b9\u3067\u3084\u3055\u3057\u304f\u5857\u5e03\u3057\u307e\u3059\u3002<\/p>\n<p>\u808c\u304c\u8352\u308c\u3066\u3044\u308b\u6642\u671f\u306f\u3001\u300c\u5857\u308b\u56de\u6570\u3092\u6e1b\u3089\u3059\u300d\u3053\u3068\u3082\u7acb\u6d3e\u306a\u30b1\u30a2\u3067\u3059\u3002<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\uff1c\u53c2\u7167\u8ad6\u6587\uff1e<\/strong><\/p>\n<p>1.Farage MA, et al. <em>Updated Perspectives on the Role of Estrogens in Skin Aging.<\/em> <em>Clin Cosmet Investig Dermatol.<\/em> 2022; 15: 2111\u20132124. doi:10.2147\/CCID.S387833<\/p>\n<p>URL: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36381976\/\" target=\"_blank\" rel=\"noopener\" data-nodal=\"\">https:\/\/pubmed.ncbi.nlm.nih.gov\/36381976\/<\/a><\/p>\n<p>\u8981\u65e8\uff08\u65e5\u672c\u8a9e\uff09\uff1a\u9589\u7d4c\u671f\u5973\u6027\u306e\u76ae\u819a\u3067\u30d0\u30ea\u30a2\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u3001\u523a\u6fc0\u306b\u654f\u611f\u5316\u3059\u308b\u904e\u7a0b\u3092\u7dcf\u8aac\u3002<\/p>\n<h2 class=\"md2\">9.\u307e\u3068\u3081\uff5c\u6b63\u3057\u3044\u4f7f\u3044\u65b9\u306750\u4ee3\u306e\u808c\u306b\u3046\u308b\u304a\u3044\u3068\u30cf\u30ea\u3092<\/h2>\n<p>50\u4ee3\u306e\u5316\u7ca7\u6c34\u306e\u4f7f\u3044\u65b9\u3092\u5e45\u5e83\u304f\u89e3\u8aac\u3057\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u304a\u3059\u3059\u3081\u306e\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u5316\u7ca7\u6c34\u300c\u30ca\u30fc\u30eb\u30b9\u30d4\u30e5\u30a2\u300d\u306e\u4f7f\u3044\u65b9\u3092\u7d39\u4ecb\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>50\u4ee3\u306e\u808c\u306f\u3001\u52a0\u9f62\u3084\u30db\u30eb\u30e2\u30f3\u30d0\u30e9\u30f3\u30b9\u306e\u5909\u5316\u306b\u3088\u3063\u3066\u3001\u4e7e\u71e5\u30fb\u30cf\u30ea\u4e0d\u8db3\u30fb\u304f\u3059\u307f\u306a\u3069\u306e\u60a9\u307f\u304c\u91cd\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u305d\u306e\u305f\u3081\u3001\u300c\u3069\u3093\u306a\u5316\u7ca7\u6c34\u3092\u9078\u3076\u304b\u300d\u3060\u3051\u3067\u306a\u304f\u3001\u300c\u3069\u3046\u4f7f\u3046\u304b\u300d\u3092\u898b\u76f4\u3059\u3053\u3068\u304c\u3001\u30a8\u30a4\u30b8\u30f3\u30b0\u30b1\u30a2\u6210\u529f\u306e\u9375\u3067\u3059\u3002<\/p>\n<p>\u672c\u8a18\u4e8b\u3067\u306f\u3001\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u3044\u305f\u5316\u7ca7\u6c34\u306e\u4f7f\u3044\u65b9\u3068\u3001\u5b63\u7bc0\u3084\u751f\u6d3b\u7fd2\u6163\u306b\u5408\u308f\u305b\u305f\u30b1\u30a2\u6cd5\u3092\u89e3\u8aac\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u91cd\u8981\u306a\u306e\u306f\u3001\u4ee5\u4e0b\u306e3\u539f\u5247\u3067\u3059\u3002<\/p>\n<ul>\n<li>\u624b\u3067\u6e29\u3081\u308b \u2013 \u5316\u7ca7\u6c34\u3092\u624b\u306e\u3072\u3089\u3067\u6e29\u3081\u3001\u808c\u306b\u512a\u3057\u304f\u30cf\u30f3\u30c9\u30d7\u30ec\u30b9\u3002\u6469\u64e6\u3092\u907f\u3051\u308b\u3053\u3068\u3067\u89d2\u8cea\u5c64\u306e\u30d0\u30ea\u30a2\u3092\u5b88\u308a\u307e\u3059\u3002<\/li>\n<li>\u53e9\u304b\u306a\u3044 \u2013 \u30d1\u30c3\u30c6\u30a3\u30f3\u30b0\u306f\u9006\u52b9\u679c\u3002\u808c\u3078\u306e\u523a\u6fc0\u304c\u708e\u75c7\u3084\u4e7e\u71e5\u3092\u62db\u304f\u305f\u3081\u3001\u5305\u307f\u8fbc\u3080\u3088\u3046\u306b\u62bc\u3055\u3048\u308b\u306e\u304c\u57fa\u672c\u3067\u3059\u3002<\/li>\n<li>\u91cd\u306d\u308b \u2013 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